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The analysis included 1552 consecutive patients with negative prevalence surveillance MRI results (Aug 2014–Dec 2016), comparing intervals \u003C3 years versus ≥3 years. Twenty-five second breast cancers occurred after negative MRI, with no significant differences in incidence or median detection intervals between groups. BRCA mutation status, breast-conserving surgery, and adjuvant chemotherapy were independently associated with second breast cancer development.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/second-breast-cancer-following-negative-breast-mri-analysis-by-interval-from-surgery-and-risk-factors/332333/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/second-breast-cancer-following-negative-breast-mri-analysis-by-interval-from-surgery-and-risk-factors/332333.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the study?","Question",{"text":112,"@type":113},"To compare outcomes after a negative surveillance MRI based on the interval from surgery and to investigate factors associated with second breast cancers in women with a personal history of breast cancer (PHBC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study designed and what comparison was made?",{"text":117,"@type":113},"This retrospective study reviewed 1552 consecutive women with PHBC and a negative prevalence surveillance breast MRI between Aug 2014 and Dec 2016, comparing surgery–MRI intervals of \u003C3 years versus ≥3 years.",{"name":119,"@type":110,"acceptedAnswer":120},"Did outcomes differ between shorter and longer surgery–MRI intervals?",{"text":121,"@type":113},"No. The incidence of second breast cancers (or local-regional recurrence) and the median intervals to detection did not significantly differ between the two interval groups.",{"name":123,"@type":110,"acceptedAnswer":124},"Which factors were independently associated with second breast cancer after a negative MRI?",{"text":125,"@type":113},"BRCA mutation status, receipt of breast-conserving surgery, and adjuvant chemotherapy were independently associated with the risk of developing second breast cancers after negative surveillance MRI.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},332333,1790013038,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","PLOS ONE  \nOPEN ACCESS  \nCitation: Joo Y, Kim MJ, Yoon JH, Rho M, Park VY (2024) Second breast cancer following negative breast MRI: Analysis by interval from surgery and risk factors. PLoS ONE 19(8): e0306828 . [https://](https://)[ ](https://)[doi.org/10.1371/journal.pone.0306828](doi.org/10.1371/journal.pone.0306828)  \n[Editor:](Editor: Daniele Ugo Tari)[ Daniele Ugo Tari](Editor: Daniele Ugo Tari), Local Health Authority Caserta: Azienda Sanitaria Locale Caserta, ITALY  \nReceived: January 12, 2024  \nAccepted: June 24, 2024  \nPublished: August 15, 2024  \nPeer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:  \n[https://doi.org/10.1371/journal.pone.0306828](https://doi.org/10.1371/journal.pone.0306828)  \n[Copyright:](Copyright:) © [2024 Joo et al](2024 Joo et al). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: All relevant data are within the manuscript and its Supporting Information files.  \nFunding: This work was supported by a new faculty research seed money grant of Yonsei  \nRESEARCH ARTICLE  \nSecond breast cancer following negative breast MRI: Analysis by interval from surgery and risk factors  \nYohan Joo, Min Jung Kim, Jung Hyun Yoon, Miribi Rho, Vivian Youngjean Park *  \nDepartment of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea  \n* vivianpark01[16@yuhs.ac](16@yuhs.ac)  \nAbstract  \nObjectives  \nThis study aims to compare outcomes following a negative surveillance MRI study by surgery-MRI interval and investigate factors associated with second breast cancers in women with a personal history of breast cancer (PHBC) .  \nMethods  \nThis retrospective study included 1552 consecutive women (mean age, 53 years) with a PHBC and a negative prevalence surveillance breast MRI result between August 2014 and December 2016. The incidence and characteristics of second breast cancers were reviewed and compared according to surgery-MRI interval (\u003C 3 years vs 􀀕 3 years) . Logistic regression analysis was used to investigate associations with clinical-pathologic characteristics.  \nResults  \nTwenty-five second breast cancers occurred after negative MRI. The incidence of second breast cancers or local-regional recurrence did not significantly differ by surgery-MRI interval. The median intervals between MRI to second breast cancer detection showed no significant difference between the two groups (surgery-MRI interval \u003C3 years vs. 􀀕 3 years) . Two node-positive second breast cancers were detected in the group with \u003C3 years interval. BRCA mutation status, receipt of breast-conserving surgery, and adjuvant chemotherapy (all p \u003C .05) were significant factors associated with the development of second breast cancers.  \nConclusion  \nOutcomes following a negative surveillance MRI did not differ by surgery-MRI interval. BRCA mutation status, receipt of breast-conserving surgery and adjuvant chemotherapy were independently associated with the risk of developing second breast cancers after negative surveillance MRI.  \nUniversity College of Medicine for 2022 (2022-32- 0074) (VYP) and a National Research Foundation of Korea (NRF) grant funded by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (Project Number: KMDF202011A01-04) (MJK) .  \nCompeting interests: The authors have declared that no competing interests exist.  \nAbbreviations: PHBC, Perso","cbCailZusAHmE27c","https://ap.wps.com/l/cbCailZusAHmE27c","pdf",867975,11,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Patients","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To compare outcomes after a negative surveillance MRI based on the interval from surgery and to investigate factors associated with second breast cancers in women with a personal history of breast cancer (PHBC).\"},{\"question\":\"How was the study designed and what comparison was made?\",\"answer\":\"This retrospective study reviewed 1552 consecutive women with PHBC and a negative prevalence surveillance breast MRI between Aug 2014 and Dec 2016, comparing surgery–MRI intervals of \\u003c3 years versus ≥3 years.\"},{\"question\":\"Did outcomes differ between shorter and longer surgery–MRI intervals?\",\"answer\":\"No. The incidence of second breast cancers (or local-regional recurrence) and the median intervals to detection did not significantly differ between the two interval groups.\"},{\"question\":\"Which factors were independently associated with second breast cancer after a negative MRI?\",\"answer\":\"BRCA mutation status, receipt of breast-conserving surgery, and adjuvant chemotherapy were independently associated with the risk of developing second breast cancers after negative surveillance MRI.\"}]","Second breast cancer following negative breast MRI - Analysis by interval from surgery and risk factors | PDF",1789997753,28]