[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-405688-105":59,"doc-detail-405688-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","sebaceous-neoplasms-review","Sebaceous Neoplasms - Review","","Sebaceous neoplasms are a tumor group showing sebaceous differentiation, typically arising in the face and neck. Most lesions are benign, while malignant tumors with sebaceous differentiation are rare. Sebaceous tumors strongly associate with Muir–Torre Syndrome, so suspected patients require excision and subsequent histopathology with additional immunohistochemistry and genetics. This review summarizes clinical and dermoscopic findings and management approaches for sebaceous carcinoma, sebaceoma/sebaceous adenoma, and sebaceous hyperplasia, with emphasis on MTS patients presenting multiple lesions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sebaceous-neoplasms-review/405688/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sebaceous-neoplasms-review/405688.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Where do sebaceous neoplasms usually occur and what is their general behavior?","Question",{"text":112,"@type":113},"They are commonly located on the face and neck. Most are benign, while malignant sebaceous differentiation tumors are uncommon.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the relationship between sebaceous tumors and Muir–Torre Syndrome?",{"text":117,"@type":113},"Sebaceous tumors have a strong association with Muir–Torre Syndrome, especially when multiple lesions are present. The review emphasizes evaluation of patients suspected of MTS.",{"name":119,"@type":110,"acceptedAnswer":120},"How were studies selected and analyzed in this review?",{"text":121,"@type":113},"The review searched multiple databases including PubMed, MEDLINE, Scopus, and Google Scholar using terms related to sebaceous neoplasms, then extracted data per neoplasm such as clinical and dermoscopic features and management, following PRISMA.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},405688,1790716633,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","diagnostics  \nReview  \nSebaceous Neoplasms  \nIlias Papadimitriou , Efstratios Vakirlis *, Elena Sotiriou , Katerina Bakirtzi , Aimilios Lallas and Demetrios Ioannides   \nCitation: Papadimitriou, I.; Vakirlis, E.; Sotiriou, E.; Bakirtzi, K.; Lallas, A.; Ioannides, D. Sebaceous Neoplasms. Diagnostics 2023, 13, 1676. [https://](https://)[ ](https://)[doi.org/10.3390/diagnostics13101676](doi.org/10.3390/diagnostics13101676)  \nAcademic Editor: Andreas Manios  \nReceived: 14 April 2023  \nRevised: 1 May 2023  \nAccepted: 5 May 2023  \nPublished: 9 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nFirst Department of Dermatology and Venereology, School of Health Science, Aristotle University of Thessaloniki, 54643 Thessaloniki, Greece  \n* Correspondence: [svakirlis@hotmail.com](svakirlis@hotmail.com)  \nAbstract: Sebaceous neoplasms describe a group of tumors with sebaceous differentiation commonly seen in lesions located primarily in the face and neck. The majority of these lesions are benign, while malignant neoplasms with sebaceous differentiation are uncommon. Sebaceous tumors present a strong association with the Muir–Torre Syndrome. Patients suspected with this syndrome should undergo neoplasm excision, followed by histopathologic and additional immunohistochemistry and genetics examinations. Clinical and dermoscopic features of the sebaceous neoplasms, as well as management procedures collected from the literature analysis regarding sebaceous carcinoma, sebaceoma/sebaceous adenoma, and sebaceous hyperplasia are described in the current review. A special note is made for describing the Muir–Torre Syndrome in patients presenting multiple sebaceous tumors.  \nKeywords: sebaceous neoplasms; sebaceous carcinoma; sebaceoma; sebaceous adenoma; sebaceous hyperplasia; Muir–Torre Syndrome  \n1. Introduction  \nSebaceous differentiation of neoplasms is represented by sebaceous carcinoma, sebaceoma, adenoma, and sebaceous hyperplasia. The benign sebaceous gland hyperplasia is very common among the general population, while malignant neoplasms, sebaceous carcinoma, sebaceoma, and adenoma are very rare. Sebaceous gland tumors can appear at any age, but they affect mainly elderly people. The group of sebaceous tumors have been strongly associated with Muir–Torre Syndrome (MTS)—when multiple lesions are present—while sebaceous hyperplasia has been correlated with chronic sun exposure. In this review, an effort was made to describe the clinical and dermoscopic features of sebaceous neoplasms, along with the management of such lesions, regarding tumor excision and the presence of MTS.  \nClinically, sebaceous tumors are often mistaken for more common malignant skin neoplasms, such as basal cell carcinoma and squamous cell carcinoma. In these cases, the diagnosis can be assisted by the use of dermoscopy and confirmed with the help of histopathology. Sebaceous tumors are mainly located on the head and neck area, but they may be traced to any region of the body. The clinical presentation can vary from small, skin-colored, umbilicated papules to ulcerated lesions, subcutaneous nodules, or exophytic tumors. The lesions are solitary except in patients with MTS. In this case, numerous sebaceous tumors may be located outside the head and neck area. Moreover, patients affected from the syndrome can present multiple keratoacanthomas, or manifest gland neoplasms at a young age.  \n2. Materials and Methods  \nFor this review, we searched the following databases: PubMed, MEDLINE, Scopus, OVID, Embase, Science Direct, Cochrane library, Research Gate, and Google Scholar. The search terms were “sebaceous neoplasms” OR “sebaceous carcinoma” OR “sebaceoma”  \n","cbCaiq50w2l4N7Hf","https://ap.wps.com/l/cbCaiq50w2l4N7Hf","pdf",1633173,13,"English","# Introduction\n# Materials and Methods\n# Epidemiology of Sebaceous Neoplasms","[{\"question\":\"Where do sebaceous neoplasms usually occur and what is their general behavior?\",\"answer\":\"They are commonly located on the face and neck. Most are benign, while malignant sebaceous differentiation tumors are uncommon.\"},{\"question\":\"What is the relationship between sebaceous tumors and Muir–Torre Syndrome?\",\"answer\":\"Sebaceous tumors have a strong association with Muir–Torre Syndrome, especially when multiple lesions are present. The review emphasizes evaluation of patients suspected of MTS.\"},{\"question\":\"How were studies selected and analyzed in this review?\",\"answer\":\"The review searched multiple databases including PubMed, MEDLINE, Scopus, and Google Scholar using terms related to sebaceous neoplasms, then extracted data per neoplasm such as clinical and dermoscopic features and management, following PRISMA.\"}]","Sebaceous Neoplasms - Review | PDF",1790561449,33]