[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-407262-105":59,"doc-detail-407262-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","searching-for-a-hiv-1-cure-review","Searching for a HIV-1 Cure - Review","","Advances in stem cell transplantation, broadly neutralizing antibodies, ultra-long-acting antiretroviral drugs, therapeutic vaccines, cell engineering, gene therapy, and immune-based molecular therapies highlight efforts to cure HIV-1. Durable eradication remains limited by durability, accessibility, delivery, off-target effects, and practicality. The review discusses combinatorial strategies using ultra-long-acting antiretrovirals, broadly neutralizing antibodies, or latency-reversing agents to reduce reservoir size and enable sustained viral suppression, emphasizing translational insights and gene-editing approaches targeting latent reservoirs and proviral DNA.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/searching-for-a-hiv-1-cure-review/407262/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/searching-for-a-hiv-1-cure-review/407262.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why have current HIV-1 cure approaches not achieved durable viral eradication?","Question",{"text":112,"@type":113},"None of the highlighted strategies have yet proven durable. Key challenges include durability, accessibility, delivery, off-target effects, and overall practicality.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which combinatorial strategies does the review emphasize for durable viral suppression?",{"text":117,"@type":113},"It discusses combinatorial therapies combining ultra-long-acting antiretrovirals and broadly neutralizing antibodies, or latency-reversing agents. These aim to reduce reservoir size while achieving sustained suppression.",{"name":119,"@type":110,"acceptedAnswer":120},"What gene-editing strategies are presented as promising for an HIV-1 cure?",{"text":121,"@type":113},"Gene-editing technologies are highlighted for disrupting proviral DNA and delivering targeted therapies. The focus is on targeting latent reservoirs and host viral receptors, including strategies such as direct viral excision and co-receptor editing.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},407262,1790665967,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Theranostics 2026, Vol. 16, Issue 5 2170  \nIvyspring  \nInternational Publisher  \nTheranostics  \n2026; 16(5): 2170-2191. doi: 10.7150/thno.124358  \nReview  \nSearching for a HIV-1 Cure  \nChen Zhang\\#, Bharat N. Chaudhary\\#, Mohammad Uzair Ali\\#, Mary G. Heser, Swara S. Patel, Xiaoqing Du, Soumya S. Dey, R. Lee Mosley, Sudipta Panja􀀍, Howard E. Gendelman􀀍  \nDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA 68198-5880.  \n\\# Equal contributions.  \n􀀍 Corresponding authors: Dr. Howard E. Gendelman (Phone: 402-559-8920; Email: [hegendel@unmc.edu](hegendel@unmc.edu); Fax: 402-559-7495) and Dr. Sudipta Panja (Email: [sudipta.panja@unmc.edu](sudipta.panja@unmc.edu)).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [https://ivyspring.com/terms](https://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2025.08.28; Accepted: 2025.11.06; Published: 2026.01.01  \nAbstract  \n\n| Advances in stem cell transplantation, broadly neutralizing antibodies, ultra-long-acting antiretroviral drugs, therapeutic vaccines, cell engineering, gene therapy, and immune-based molecular therapies have highlighted efforts to cure human immunodeficiency virus type 1 (HIV-1). However, none of these are durable. The challenges to achieve complete viral eradication include durability, accessibility, delivery, off-target effects, and practicality. All approaches, including combinatorial therapies with ultra-long-acting antiretrovirals, broadly neutralizing antibodies, or latency-reversing agents, which reduce reservoir size and achieve durable viral suppression, are discussed. These include key translational insights for clinical relevance. Among these, gene-editing technologies have shown promise in disrupting proviral DNA and delivering targeted therapies by targeting latent reservoirs and host viral receptors. This review examines the scientific, clinical, and ethical considerations, focusing on direct viral excision and co-receptor editing as key strategies for a viral cure. |  |\n| --- | --- |\n| Keywords: CRISPR, CRISPR-Cas9, CCR5, CXCR4, CD4, Gene Delivery, HIV-1 suppression, Viral resistance, Combination antiretroviral therapy, HIV-1 replication\u003Cbr>1. Introduction |  |\n| 1.1 Insights of historical relevance from HIV-1 discovery to the present day\u003Cbr>Human immunodeficiency virus type 1 (HIV-1) infection causes acquired immunodeficiency syndrome (AIDS) . AIDS was first recognized in the early 1980s as a life-threatening condition that primarily affects men who have sex with other men [1]. The syndrome is characterized by the rapid onset of opportunistic infections, such as Pneumocystis pneumonia, and rare cancers, such as Kaposi’s sarcoma. In 1983, scientists at the Pasteur Institute, led by Drs. Luc Montagnier and Françoise Barré-Sinoussi isolated a retrovirus from the lymph node biopsies of an individual with AIDS [2] . This virus was first identified as the lymphadenopathy-associated virus (LAV) and human T-lymphotropic virus type III (HTLV-III), both of which selectively target CD4+ T cells. In 1984, Dr. Robert Gallo and colleagues at the US National Institutes of Health (NIH) confirmed that the isolated virus was responsible for AIDS [3] . | Subsequent studies elucidated the virus structure, function, and genetic composition and renamed it HIV-1. This discovery marked a significant milestone in establishing the cause of the disease, facilitating successful diagnosis, and ultimately leading to effective antiretroviral (ARV) drug treatment [4] . From 1984 to 1986, recombinant viral clones were ultimately created, leading to the creation of full-length molecular clones of HIV-1 [5-7] . Molecular and biochemical analyses have confirmed that HIV-1 has nine key genes in the viral RNA gene sequence that are associated with","cbCailAxNP1Nrysp","https://ap.wps.com/l/cbCailAxNP1Nrysp","pdf",5255337,22,"English","# Abstract\n## Keywords\n## Introduction\n## Insights of historical relevance from HIV-1 discovery to the present day","[{\"question\":\"Why have current HIV-1 cure approaches not achieved durable viral eradication?\",\"answer\":\"None of the highlighted strategies have yet proven durable. Key challenges include durability, accessibility, delivery, off-target effects, and overall practicality.\"},{\"question\":\"Which combinatorial strategies does the review emphasize for durable viral suppression?\",\"answer\":\"It discusses combinatorial therapies combining ultra-long-acting antiretrovirals and broadly neutralizing antibodies, or latency-reversing agents. These aim to reduce reservoir size while achieving sustained suppression.\"},{\"question\":\"What gene-editing strategies are presented as promising for an HIV-1 cure?\",\"answer\":\"Gene-editing technologies are highlighted for disrupting proviral DNA and delivering targeted therapies. The focus is on targeting latent reservoirs and host viral receptors, including strategies such as direct viral excision and co-receptor editing.\"}]","Searching for a HIV-1 Cure - Review | PDF",1790572366,55]