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Scutellaria baicalensis is described as a herbal medicine with anti-cancer activity, and multiple studies indicate that its flavonoids exert anti-ovarian cancer effects. The review summarizes ovarian cancer pathogenesis across proliferation, cell-cycle control, invasion and metastasis, apoptosis and autophagy, drug resistance, and angiogenesis, and details mechanisms for key flavonoids including wogonin, baicalein, baicalin, Oroxylin A, and scutellarein. It evaluates their therapeutic advantages and limitations to guide future research and development.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/scutellaria-baicalensis-georgi-and-their-natural-flavonoid-compounds-in-the-treatment-of-ovarian-cancer-a-review/383803/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/scutellaria-baicalensis-georgi-and-their-natural-flavonoid-compounds-in-the-treatment-of-ovarian-cancer-a-review/383803.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is ovarian cancer treatment difficult according to the review?","Question",{"text":112,"@type":113},"Ovarian cancer shows high mortality and poor prognosis, with advanced-stage patients frequently experiencing chemotherapy resistance and recurrence exceeding 50%. Chemotherapy also brings significant toxicity that adds to patient burden.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does Scutellaria baicalensis contribute in treating ovarian cancer?",{"text":117,"@type":113},"Scutellaria baicalensis is presented as having anti-cancer activity, with studies indicating its flavonoids can inhibit ovarian cancer processes. The review connects its effects to multiple mechanisms including proliferation control and improved responses against drug resistance.",{"name":119,"@type":110,"acceptedAnswer":120},"Which flavonoid compounds are highlighted as having anti-ovarian cancer mechanisms?",{"text":121,"@type":113},"The review emphasizes wogonin, baicalein, baicalin, Oroxylin A, and scutellarein. Reported actions include inhibiting proliferation, inducing apoptosis, blocking invasion and metastasis, and reducing factors such as VEGF expression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383803,1790688745,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","molecules   \nReview  \nScutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review  \nJiaying Cai 1,2,3,†, Qichao Hu 4,†, Zhelin He 5, Xiaoyan Chen 5, Jian Wang 5, Xiang Yin 5, Xiao Ma 4, * and Jinhao Zeng 1,2,3, *  \nCitation: Cai, J.; Hu, Q.; He, Z.; Chen, X.; Wang, J.; Yin, X.; Ma, X.; Zeng, J. Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: AReview. Molecules 2023, 28, 5082 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules28135082  \nAcademic Editors: Eun Kyoung Seo, Irwin Rose Alencar Menezes, Henrique Douglas Melo Coutinho, Almir Gonçalves Wanderley and Jaime Ribeiro-Filho  \nReceived: 19 May 2023  \nRevised: 21 June 2023  \nAccepted: 27 June 2023  \nPublished: 29 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China; [a13108078158@163.com](a13108078158@163.com)  \n2 Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China  \n3 School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China  \n4 State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; [huqichaotcm@163.com](huqichaotcm@163.com)  \n5 Endoscopy Center, Guang'an Hospital of Traditional Chinese Medicine, Guang'an 638000, China; [m18090520007@163.com](m18090520007@163.com) (Z.H.); [13659096828@163.com](13659096828@163.com) (X.C.); [13568396305@163.com](13568396305@163.com) (J.W.); [18282619179@163.com](18282619179@163.com) (X.Y.)  \n* Correspondence: [tobymaxiao@cdutcm.edu.cn](tobymaxiao@cdutcm.edu.cn) (X.M.); [zengjinhao@cdutcm.edu.cn](zengjinhao@cdutcm.edu.cn) (J.Z.)† These authors contributed equally to this work.  \nAbstract: Ovarian cancer (OC) is one of the most common types of cancer in women with a high mortality rate, and the treatment of OC is prone to high recurrence rates and side effects. Scutellaria baicalensis (SB) is a herbal medicine with good anti-cancer activity, and several studies have shown that SB and its flavonoids have some anti-OC properties. This paper elucidated the common pathogenesis of OC, including cell proliferation and cell cycle regulation, cell invasion and metastasis, apoptosis and autophagy, drug resistance and angiogenesis. The mechanisms of SB and its flavonoids, wogonin, baicalein, baicalin, Oroxylin A, and scutellarein, in the treatment of OC, are revealed, such as wogonin inhibits proliferation, induces apoptosis, inhibits invasion and metastasis, and increases the cytotoxicity of the drug. Baicalein also inhibits vascular endothelial growth factor (VEGF) expression etc. Analyzing their advantages and disadvantages in treating OC provides a new perspective on the role of SB and its flavonoids in OC treatment. It serves as a resource for future OC research and development.  \nKeywords: Scutellaria baicalensis; ovarian cancer; flavonoid; Chinese medicine; pathogenesis  \n1. Introduction  \nOvarian cancer (OC) is one of the most common and deadly cancers in women worldwide, with the highest mortality rate and the worst prognosis of all gynecological malignancies. Many women are diagnosed with OC each year, and the 5-year recurrence rate for advanced OC can be as high as 70%[1,2] . Based on histological and embryological features, there are three main types of OC: epithelial, germ cell and mesenchymal gonadotrophic, of which ","cbCaiaBqJeIWDnmI","https://ap.wps.com/l/cbCaiaBqJeIWDnmI","pdf",1896776,18,"English","# Introduction\n## Ovarian cancer overview\n## Treatment challenges and recurrence\n## Scutellaria baicalensis as a traditional anticancer herb\n# Mechanisms and therapeutic effects\n## Proliferation and cell-cycle regulation\n## Invasion, metastasis, apoptosis, and autophagy\n## Drug resistance and angiogenesis\n# Key flavonoid compounds\n## Wogonin\n## Baicalein\n## Baicalin, Oroxylin A, and scutellarein\n# Advantages and disadvantages\n## Research and development outlook","[{\"question\":\"Why is ovarian cancer treatment difficult according to the review?\",\"answer\":\"Ovarian cancer shows high mortality and poor prognosis, with advanced-stage patients frequently experiencing chemotherapy resistance and recurrence exceeding 50%. Chemotherapy also brings significant toxicity that adds to patient burden.\"},{\"question\":\"What does Scutellaria baicalensis contribute in treating ovarian cancer?\",\"answer\":\"Scutellaria baicalensis is presented as having anti-cancer activity, with studies indicating its flavonoids can inhibit ovarian cancer processes. The review connects its effects to multiple mechanisms including proliferation control and improved responses against drug resistance.\"},{\"question\":\"Which flavonoid compounds are highlighted as having anti-ovarian cancer mechanisms?\",\"answer\":\"The review emphasizes wogonin, baicalein, baicalin, Oroxylin A, and scutellarein. Reported actions include inhibiting proliferation, inducing apoptosis, blocking invasion and metastasis, and reducing factors such as VEGF expression.\"}]","Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer - A Review | PDF",1790259301,45]