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The review discusses key screening and surveillance approaches, including colonoscopy, genetic testing, and imaging.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/screening-and-surveillance-for-hereditary-colorectal-cancer-review/327600/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/screening-and-surveillance-for-hereditary-colorectal-cancer-review/327600.png","ImageObject",300,407,{"name":42,"@type":43},"Aurora","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What distinguishes hereditary colorectal cancer from sporadic colorectal cancer?","Question",{"text":63,"@type":64},"Hereditary colorectal cancer results from inherited genetic mutations. Sporadic cases usually lack significant genetic components, while hereditary disease accounts for a smaller fraction of total colorectal cancer cases.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why are screening and surveillance important in hereditary colorectal cancer?",{"text":68,"@type":64},"Screening and surveillance help detect precancerous or cancerous changes and track disease progression. Early detection and treatment can improve patient outcomes and reduce mortality.",{"name":70,"@type":61,"acceptedAnswer":71},"What tests are discussed as examples of screening and surveillance?",{"text":72,"@type":64},"The review highlights colonoscopy, genetic testing, and imaging tests as examples of screening and surveillance tools for hereditary colorectal cancer.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},327600,1790099305,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":112},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","| REVIEW\u003Cbr>| |\n| --- | --- |\n| pISSN 1598-9100 • eISSN 2288-1956 [https://doi.org/10.5217/ir.2023.00112](https://doi.org/10.5217/ir.2023.00112)[ ](https://doi.org/10.5217/ir.2023.00112)[Intest Res 2024](Intest Res 2024) ;[22](22)([2](2)) [:119-130](:119-130) |  |\n| Screening and surveillance for hereditary colorectal cancer\u003Cbr>Hee Man Kim1,2, Tae Il Kim1,2\u003Cbr>1Cancer Prevention Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; 2Division of Gastroenterology, Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea\u003Cbr>Hereditary colorectal cancer is a type of cancer that is caused by a genetic mutation. Individuals with a family history of colorectal cancer, or who have a known hereditary syndrome, are at an increased risk of developing the disease. Screening and surveillance are important tools for managing the risk of hereditary colorectal cancer. Screening involves a combination of tests that can detect precancerous or cancerous changes in the colon and rectum. Surveillance involves regular follow-up examinations to monitor disease progression and to identify new developments. The frequency and type of screening and surveillance tests may vary depending on an individual’s risk factors, genetic profile, and medical history. However, early detection and treatment of hereditary colorectal cancer can significantly improve patient outcomes and reduce mortality rates. By implementing comprehensive screening and surveillance strategies, healthcare providers can help individuals at risk of hereditary colorectal cancer to receive timely interventions and make informed decisions about their health. Specific examples of screening and surveillance tests for hereditary colorectal cancer include colonoscopy, genetic testing, and imaging tests. In this review article, we will discuss detailed screening and surveillance of hereditary colorectal cancer. (Intest Res 2024;22:119-130)\u003Cbr>KeyWords: Hereditary nonpolyposis colorectal cancer; Familial adenomatous polyposis; Colorectal neoplasm; Early detection of cancer |  |\n\nINTRODUCTION  \nColorectal cancer (CRC) is one of the most common cancers worldwide. Most CRC cases (approximately 70%) are sporadic and lack significant genetic components.1 In contrast, approximately 30% of all CRC cases are genetically predisposed.2 Hereditary CRC is a subset of genetically predisposed CRC that occurs because of inherited genetic mutations and accounts for up to 5% of all CRC cases.3 Lynch syndrome (LS) and familial adenomatous polyposis (FAP) account for an estimated 2%–4% and \u003C 1% of all CRCs, respectively, and are representa-  \nReceived September 1, 2023. Revised November 8, 2023.  \nAccepted November 27, 2023.  \nCorrespondence to Tae Il Kim, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. Tel: +82-2-2228-1965, Fax: +82-2-393-6884, E-mail: [taeilkim@yuhs.ac](taeilkim@yuhs.ac)  \ntive hereditary CRC types characterized by mutated genes.4,5 These gene mutations increase the risk of developing CRC atan early age and can also increase the risk of developing other types of cancer. The timely identification of individuals with hereditary CRC is crucial for implementing appropriate surveillance and prevention strategies, ultimately reducing morbidity and mortality rates.  \nHereditary CRC encompasses a group of diseases or syndromes resulting from mutations in specific genes that lead to distinct clinical phenotypes (Table 1).2,5,6 These conditions include LS, FAP, MUTYH-associated polyposis (MAP), juvenile polyposis syndrome (JPS), Peutz-Jeghers syndrome (PJS), Cowden syndrome, and polymerase proofreading-associated polyposis.  \nGenetic counseling is recommended for individuals with a personal or family history of hereditary CRC syndromes.7,8 Dur-  \n© Copyright 2024. Korean Association for the Study of Intestinal Diseases.  \nThis is an Open Access articl","cbCainwVWhys6LZU","https://ap.wps.com/l/cbCainwVWhys6LZU","pdf",1262004,12,"English","# Introduction\n## Hereditary colorectal cancer and genetic predisposition\n## Genetic counseling and genetic testing\n# Types and gene mutations\n## Lynch syndrome and related syndromes\n# Screening and surveillance strategies\n## Colonoscopy, genetic testing, and imaging","[{\"question\":\"What distinguishes hereditary colorectal cancer from sporadic colorectal cancer?\",\"answer\":\"Hereditary colorectal cancer results from inherited genetic mutations. Sporadic cases usually lack significant genetic components, while hereditary disease accounts for a smaller fraction of total colorectal cancer cases.\"},{\"question\":\"Why are screening and surveillance important in hereditary colorectal cancer?\",\"answer\":\"Screening and surveillance help detect precancerous or cancerous changes and track disease progression. Early detection and treatment can improve patient outcomes and reduce mortality.\"},{\"question\":\"What tests are discussed as examples of screening and surveillance?\",\"answer\":\"The review highlights colonoscopy, genetic testing, and imaging tests as examples of screening and surveillance tools for hereditary colorectal cancer.\"}]","Screening and surveillance for hereditary colorectal cancer - Review | PDF",1789977632]