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SCIN shows differential expression across nine cancer types, with strong associations between SCIN expression and prognosis and immune cell infiltration, especially in liver hepatocellular carcinoma. Functional analyses indicate that SCIN knockdown can suppress tumor cell proliferation and improve survival in animal models. 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BY  \nAlessandro Poggi,  \nSan Martino Hospital (IRCCS), Italy  \nREVIEWED BY  \nAntonella Argentiero,  \nNational Cancer Institute Foundation (IRCCS), Italy  \nYize Li,  \nWashington University in St. Louis, United States  \n*CORRESPONDENCE Lingyu Zhu  \n [Zhulingyu0627@163.com](Zhulingyu0627@163.com)  \nRECEIVED 26 December 2023  \nACCEPTED 05 July 2024  \nPUBLISHED 23 July 2024  \nCITATION  \nZhai S, Li Y, Yang Y, Lang W, Liu X, Liu K, Qu Jand Zhu L (2024) Scinderin is a potential prognostic biomarker and correlated with immunological regulation: from pan-cancer analysis to liver hepatocellular carcinoma. Front. Immunol. 15:1361657 .  \ndoi: 10.3389/fimmu.2024.1361657  \nCOPYRIGHT  \n© 2024 Zhai, Li, Yang, Lang, Liu, Liu, Qu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nScinderin is a potential prognostic biomarker and correlated with immunological regulation: from pan-cancer analysis to liver hepatocellular carcinoma  \nShengyong Zhai 1, Yuhua Li 1, Yuanyuan Yang2, Wei Lang 1, Xiaoxia Liu 3, Kai Liu 1, Jianjun Qu 1 and Lingyu Zhu 4*  \n1 Department of Gastrointestinal Surgery, Weifang People’s Hospital, The First Affiliated Hospital of Weifang Medical College, Weifang, Shandong, China, 2 Department of Nuclear Medicine, Weifang People’s Hospital, The First Affiliated Hospital of Weifang Medical College, Weifang, Shandong, China, 3 Department of Anesthesiology, Weifang People’s Hospital, The First Affiliated Hospital of Weifang Medical College, Weifang, Shandong, China, 4 Department of Gastroenterology, Weifang People’s Hospital, The First Affiliated Hospital of Weifang Medical College, Weifang, Shandong, China  \nAim: This study aimed to systematically dissect the role of Scinderin (SCIN) in tumorigenesis.  \nMethods: Bioinformatics techniques were employed based on cancer data from TCGA, ENCORI, HPA, GEPIA2, UALCAN, Kaplan-Meier plotter, TIMER, TISIDB, cBioPortal, HCCDB, GeneMANIA and LinkedOmics database. Experiments in vitro and in vivo were conducted to dissect the role of SCIN in liver hepatocellular carcinoma (LIHC) .  \nResults: Significantly differential expression of SCIN was found in nine types of cancers, including LIHC. Through pan-cancer analysis, the correlations between SCIN expression with prognosis and immune cell infiltration were proven, especially in LIHC, ovarian serous cystadenocarcinoma and lung adenocarcinoma. The highest frequency of alteration in SCIN (6 . 81%) was seen in patients with uterine corpus endometrial carcinoma, in which “mutation” was the predominant type, with a frequency of about 5.29%; meanwhile, S673F and  \nAbbreviations: ACC, Adrenocortical carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, Cholangio carcinoma; COAD, Colon adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; HNSC, Head and Necksquamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LGG, Brain Lower Grade Glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MESO, Mesothelioma; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; STAD, Stomach adenocarcinoma;","cbCaisEqqjhQDr2H","https://ap.wps.com/l/cbCaisEqqjhQDr2H","pdf",11386613,17,"English","# Introduction\n# Aim\n# Methods\n## Bioinformatics analysis\n## In vitro and in vivo experiments\n# Results\n# Conclusion","[{\"question\":\"What was the study aim regarding Scinderin (SCIN)?\",\"answer\":\"The study aimed to systematically dissect the role of Scinderin (SCIN) in tumorigenesis and evaluate its potential prognostic significance.\"},{\"question\":\"How was SCIN analyzed across cancers?\",\"answer\":\"Bioinformatics analyses were performed using cancer datasets and multiple public databases, followed by comparative evaluation of SCIN expression, prognosis associations, and links to immune infiltration and related molecular features.\"},{\"question\":\"What did functional experiments show about SCIN in liver hepatocellular carcinoma?\",\"answer\":\"In vitro and in vivo experiments suggested that SCIN knockdown could suppress tumor cell proliferation and improve survival in animal models, supporting SCIN’s role in tumor progression.\"}]","Scinderin is a potential prognostic biomarker and correlated with immunological regulation - from pan-cancer analysis to liver hepatocellular carcinoma | PDF",1789991780,43]