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Publications from 1985–2024 were retrieved from the Web of Science Core Collection and analyzed to characterize publication trends, regional and institutional contributions, journal distributions, co-cited references, and keyword evolution. Results include 2882 articles across 91 regions and 2865 institutions, identifying major themes and shifting focus toward mechanisms and translational pathways.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/scientific-mapping-and-knowledge-evolution-of-global-areca-research-scientific-research-report/451000/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/scientific-mapping-and-knowledge-evolution-of-global-areca-research-scientific-research-report/451000.png","ImageObject",300,407,{"name":92,"@type":93},"Putri","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of this study on global areca research?","Question",{"text":112,"@type":113},"It provides a comprehensive bibliometric overview to clarify publication trends, intellectual structure, and emerging research frontiers in areca-related studies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data source and time range were used to collect publications?",{"text":117,"@type":113},"Publications from 1985 to 2024 were retrieved from the Web of Science Core Collection.",{"name":119,"@type":110,"acceptedAnswer":120},"What major research themes were identified from co-citation and keyword analyses?",{"text":121,"@type":113},"Key thematic domains include areca toxicity, oral submucous fibrosis, oral cancer, and synergistic effects with tobacco and alcohol.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},451000,1790874280,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Scientific Research Report  \nScientific Mapping and Knowledge Evolution of Global Areca Research  \nChuanyang Dinga,b,\\#, Yingying Cuia,\\#, Tiejun Lib*, Xinjia Caia*  \na Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China b Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China  \n| A R T I C L E I N F O | A B S T R A C T |\n| --- | --- |\n| Article history:\u003Cbr>Received 29 October 2025\u003Cbr>Received in revised form\u003Cbr>21 November 2025\u003Cbr>Accepted 26 November 2025\u003Cbr>Available online 19 December 2025 | Introduction and aims: Areca, a widely used psychoactive substance, has been classified as a Group I carcinogen due to its strong association with oral potentially malignant disordersand oral cancer. This study aimed to provide a comprehensive bibliometric overview of global areca-related research, elucidating its publication trends, intellectual structure, and emerging research frontiers.\u003Cbr>Methods: Publications from 1985 to 2024 were retrieved from the Web of Science Core Collection. Bibliometric analyses were performed to visualize publication outputs, regional and institutional contributions, journal distributions, co-cited references, and keyword evolution. Temporal and network analyses were conducted to identify major research clusters and developmental trajectories.\u003Cbr>Results: A total of 2882 articles from 91 regions and 2865 institutions were analysed. Global publications have increased markedly over the past decade. Among the leading contributing regions are India, Taiwan, China, and the Chinese mainland. Co-citation and keyword analyses revealed several major thematic domains: areca toxicity, oral submucous fibrosis, oral cancer, and synergistic effects with tobacco and alcohol. Recent trends indicate a shift from epidemiological and clinical characterization toward mechanistic and translational studies, focusing on fibrosis and carcinogenic signalling pathways.\u003Cbr>Conclusion: This study provides the comprehensive landscape of global areca research, outlining its intellectual evolution and emerging frontiers. Integrating multidisciplinary and international collaborations will be critical for advancing mechanistic understanding and guiding evidence-based prevention strategies.\u003Cbr>Clinical Relevance: By elucidating the global research landscape of areca, this analysis offers a scientific foundation for developing targeted public health interventions and clinical strategies to mitigate areca-related oral diseases and carcinogenesis.\u003Cbr>􀀁 2025 The Authors. Published by Elsevier Inc. on behalf ofFDI World Dental Federation. This is an open access article under the CC BY-NC-ND license\u003Cbr>([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)) |\n| Key words:\u003Cbr>Areca\u003Cbr>Oral potentially malignant disorders Cancer\u003Cbr>Public health\u003Cbr>Epidemiology |  |\n\n* Corresponding authors. Xinjia Cai, Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. Tiejun Li, Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, 100081, China.  \nE-mail addresses: [litiejun22@vip.sina.com](litiejun22@vip.sina.com) (T. Li), [caixinjia1994@163.com](caixinjia1994@163.com) (X. Cai).  \nXinjia Cai: [http://orcid.org/0000-0002-3212-7474](http://orcid.org/0000-0002-3212-7474)  \n\\# Chuanyang Ding and Yingying Cui contributed equally to this study.  \n[https://doi.org/10.1016/j.identj.2025.109342](https://doi.org/10.1016/j.identj.2025.109342)  \nIntroduction  \nAreca, also known as areca catechu or betel nut, is","cbCaio9T6KtyRgfO","https://ap.wps.com/l/cbCaio9T6KtyRgfO","pdf",4256611,12,"English","# Introduction\n# Methods\n# Results\n# Conclusion\n# Clinical Relevance","[{\"question\":\"What is the purpose of this study on global areca research?\",\"answer\":\"It provides a comprehensive bibliometric overview to clarify publication trends, intellectual structure, and emerging research frontiers in areca-related studies.\"},{\"question\":\"Which data source and time range were used to collect publications?\",\"answer\":\"Publications from 1985 to 2024 were retrieved from the Web of Science Core Collection.\"},{\"question\":\"What major research themes were identified from co-citation and keyword analyses?\",\"answer\":\"Key thematic domains include areca toxicity, oral submucous fibrosis, oral cancer, and synergistic effects with tobacco and alcohol.\"}]","Scientific Mapping and Knowledge Evolution of Global Areca Research - Scientific Research Report | PDF",1790734183]