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The review reports outcomes showing Raman spectroscopy can provide significant diagnostic information, supported by extensive pre-clinical experiments using in vitro cells, in vivo animal models, and ex vivo human tissues. It highlights development of in vivo Raman handheld probes for real-time detection of breast and brain tumors with sensitivity and specificity, while noting the need to further explore Raman biomarkers for other cancer types. Raman spectroscopy is presented as an effective, valuable tool for future rapid clinical diagnostics.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/scientific-advances-in-cancer-detection-using-raman-spectroscopy-research-article/331761/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/scientific-advances-in-cancer-detection-using-raman-spectroscopy-research-article/331761.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the aim of the study on Raman spectroscopy for cancer detection?","Question",{"text":112,"@type":113},"The study aims to investigate Raman spectroscopy’s role in cancer detection and assess its diagnostic potential for cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the evidence for Raman spectroscopy in cancer detection gathered?",{"text":117,"@type":113},"The review explored research studies by searching scientific databases including PubMed, Web of Science, Embase, and Google Scholar.",{"name":119,"@type":110,"acceptedAnswer":120},"What diagnostic scenarios and performance are highlighted in the results?",{"text":121,"@type":113},"The results describe pre-clinical experiments across in vitro, in vivo, and ex vivo settings, and development of in-vivo handheld Raman probes used for real-time detection of breast and brain tumors with significant sensitivity and specificity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331761,1790498234,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","RESEARCH ARTICLE  \nEditorial Process: Submission:06/05/2024 Acceptance:11/27/2024  \nScientific Advances in Cancer Detection Using Raman Spectroscopy  \nGourav Kumar Jain1 *, Rajni Verma1, Arun Chougule2, Bharti Singh3 Abstract  \nAim: The present study is focused to investigate the role of Raman spectroscopy (RM) for cancer detection. Methods: In this review, we explored a number of scientific databases including PubMed, Web of Science, Embase and Google Scholar for research studies on Raman spectroscopy for diagnosing cancer. We reported key outcomes of research studies conducted involving Raman spectroscopy for diagnosis of cancer and highlighting the potential of novel Raman spectroscopy for diagnosing cancer in our review. Results: Based on the available evidence it can be strongly concluded that Raman spectroscopy provide significant information for diagnosing cancer. Numerous comprehensive studies involving living cells in vitro, in-vivo animal models and ex-vivo human tissues pre-clinical Raman experiments are conducted on biological specimens for almost every type of cancer for diagnosing cancer demonstrating the potential for clinical use of Raman spectroscopy. Furthermore, the in-vivo Raman handheld probes are developed and experimentally used for real time detection of human breast and brain tumors with significant sensitivity and specificity. However, it will be important and challenging to explore relevant Raman biomarkers for other types of cancer as well, to distinguish cancer. Conclusion: Raman spectroscopy is an effective method and valuable tool in the field of cancer diagnostics. The Raman spectroscopy deserves a place for future in clinics for rapid cancer diagnostics.  \nKeywords: Cancer-Raman spectroscopy-Diagnosis-Spectrum  \nAsian Pac J Cancer Prev, 25 (11), 3977-3986  \nIntroduction  \nBackground  \nLiving organisms are immensely complex biological systems. The living biological systems are remarkably ordered and compactly arranged together ina highly efficient way. Living systems store sensitive genetic information for repetitive cellular reproduction, organization, control, and many other functions. However, infection or mutation in the biological mechanisms leads to progression of disease. Amongst all diseases, cardiovascular diseases and cancer are the leading causes of mortality worldwide [1, 2]. Thereis an urgent need for finding point of care procedures and techniques for the correct diagnosis for diseases with ease of use. Different physical effects are used, and various techniques are applied to achieve diagnostic information that is not directly visible. Raman spectroscopy (RM) has prospective applications for non-invasive use in a broad range of clinical diagnostics. RM has always benefited mankind from its involvement with ever advancing and developing sciences. It is a well-established, well recognized subject; however, the use of RM is recent and fast-growing in detection of cancer [3, 4] .  \nRM has now become an indispensable tool for  \nreporting molecular vibrational frequencies and chemical analyses in industrial and research laboratories. However, the use of RM for biomedical applications was first published in 1970 [5]. Later, the emergence of RM became possible for biomedical applications with the advent of immense advances in light sources and signal detection techniques. Over the last decade, RM has been explored extensively in biomedical applications and gained research interest in clinical laboratories. Molecular substances can be identified, and biochemical vibrations can be monitored with high specificity through distinct Raman spectroscopic patterns. RM is a powerful tool for biomedical applications because of the fact that the laser excitation wavelength invisible and near-infrared range has a high spatial resolution for studying molecular information in biological samples. RM provides information of the composition of individual groups of atoms and the changes occurring in the sha","cbCaidq5VURkBS7s","https://ap.wps.com/l/cbCaidq5VURkBS7s","pdf",443824,"English","# Introduction\n## Background\n# Methods and Review Approach\n## Literature Databases Searched\n# Results\n## Diagnostic Potential and Clinical-Use Readiness\n## In-vivo Handheld Raman Probes\n# Discussion and Challenges\n## Need for Additional Raman Biomarkers\n# Conclusion","[{\"question\":\"What is the aim of the study on Raman spectroscopy for cancer detection?\",\"answer\":\"The study aims to investigate Raman spectroscopy’s role in cancer detection and assess its diagnostic potential for cancer.\"},{\"question\":\"How was the evidence for Raman spectroscopy in cancer detection gathered?\",\"answer\":\"The review explored research studies by searching scientific databases including PubMed, Web of Science, Embase, and Google Scholar.\"},{\"question\":\"What diagnostic scenarios and performance are highlighted in the results?\",\"answer\":\"The results describe pre-clinical experiments across in vitro, in vivo, and ex vivo settings, and development of in-vivo handheld Raman probes used for real-time detection of breast and brain tumors with significant sensitivity and specificity.\"}]","Scientific Advances in Cancer Detection Using Raman Spectroscopy - Research Article | PDF",1789995006,25]