[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-428481-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-428481-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","sarcopenia-towards-a-global-definition-and-the-potential-for-therapeutic-treatments","SARCOPENIA: TOWARDS A GLOBAL DEFINITION AND THE POTENTIAL FOR THERAPEUTIC TREATMENTS","","Sarcopenia, the age-related loss of skeletal muscle mass and function, drives well-characterized functional limitations and adverse outcomes including physical disability, falls, fractures, and death. Physiological changes in skeletal muscle force and power generation appear tied to alterations in contractile protein function, metabolic derangements, and neuromuscular activation. Key biology shifts include gene transcription changes, mitochondrial stability loss, reduced anabolic capacity, cellular senescence, and diminished metabolic flexibility, with molecular targets enabling therapeutic development. The presentation reviews emerging pathways beyond androgen receptor activation and myostatin signaling, summarizes related clinical trial data, and addresses regulatory barriers such as the need for global consensus definitions and treatment guidelines.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/sarcopenia-towards-a-global-definition-and-the-potential-for-therapeutic-treatments/428481/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/sarcopenia-towards-a-global-definition-and-the-potential-for-therapeutic-treatments/428481.png","ImageObject",300,407,{"name":42,"@type":43},"Franzy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What clinical outcomes are linked to sarcopenia?","Question",{"text":63,"@type":64},"Sarcopenia is associated with functional limitations and physical disability, with distal outcomes including falls, fractures, and death.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which biological processes in skeletal muscle are relevant to sarcopenia?",{"text":68,"@type":64},"Age-associated changes include alterations in gene transcription, mitochondrial stability, anabolic capacity, cellular senescence, and metabolic flexibility, alongside changes in contractile protein function and neuromuscular activation.",{"name":70,"@type":61,"acceptedAnswer":71},"What therapeutic approaches are highlighted as potential treatments for sarcopenia?",{"text":72,"@type":64},"Two major classes are selective androgen receptor activation and inhibition of myostatin signaling. Additional promising pathways include selective activation of skeletal muscle troponin proteins and strategies that stimulate mitochondrial biogenesis or stability.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},428481,1790772528,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30,"preview_page_count":4},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Innovation in Aging, 2025, Vol. 9, No. S2 377  \nAbstract citation ID: igaf122.1280  \nSARCOPENIA: TOWARDS A GLOBAL DEFINITION  \nAND THE POTENTIAL FOR THERAPEUTIC  \nTREATMENTS  \nRoger Fielding, Tufts University, Medford, Massachusetts, United States  \nThe age-related loss of skeletal muscle mass and function, sarcopenia, is associated with well-characterized functional limitations, physical disability, and distal clinically relevant outcomes such as falls, fractures, and death. Underlying these age-related changes are physiological changes in the force/power generating capacity of skeletal muscle that appear to be driven by changes in skeletal contractile protein function, metabolic derangements and alterations in neuromuscular activation.  \nBiologically-relevant age-associated changes in skeletal muscle biology include alterations in gene transcription, mitochondrial stability, anabolic capacity, cellular senescence and metabolic flexibility. Underlying molecular targets have been identified in skeletal muscle that are potential sites for the development of therapeutic interventions. In my presentation, I will provide a state-of-the-art update on key therapeutic targets for components of the sarcopenia syndrome. Two major classes of therapies, selective androgen receptor activation and inhibition of myostatin signaling, have been proposed as targets for treatment of sarcopenia. However, more recently, additional relevant novel pathways have been uncovered that show promise. These include approaches that target skeletal muscle excitation-contraction coupling such as the selective activation of skeletal muscle troponin proteins, and targets that stimulate biogenesis or stability of mitochondria and their upstream activators. I will summarize the available clinical trials data on these emerging novel pathways and discuss the barriers towards regulatory approval for these indications which include the need to develop an international consensus definition of sarcopenia and establishment of treatment guidelines.","cbCaib5AqeR9ZMye","https://ap.wps.com/l/cbCaib5AqeR9ZMye","pdf",373887,"English","# Overview of Sarcopenia and Clinical Consequences\n## Biology, Molecular Targets, and Mechanisms\n# Therapeutic Strategies and Emerging Pathways\n## Androgen Receptor Activation and Myostatin Inhibition\n## Novel Targets: Excitation-Contraction Coupling and Mitochondria\n# Clinical Trial Evidence and Regulatory Barriers\n## Need for Global Consensus Definitions and Guidelines","[{\"question\":\"What clinical outcomes are linked to sarcopenia?\",\"answer\":\"Sarcopenia is associated with functional limitations and physical disability, with distal outcomes including falls, fractures, and death.\"},{\"question\":\"Which biological processes in skeletal muscle are relevant to sarcopenia?\",\"answer\":\"Age-associated changes include alterations in gene transcription, mitochondrial stability, anabolic capacity, cellular senescence, and metabolic flexibility, alongside changes in contractile protein function and neuromuscular activation.\"},{\"question\":\"What therapeutic approaches are highlighted as potential treatments for sarcopenia?\",\"answer\":\"Two major classes are selective androgen receptor activation and inhibition of myostatin signaling. Additional promising pathways include selective activation of skeletal muscle troponin proteins and strategies that stimulate mitochondrial biogenesis or stability.\"}]","SARCOPENIA: TOWARDS A GLOBAL DEFINITION AND THE POTENTIAL FOR THERAPEUTIC TREATMENTS | PDF",1790646792]