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This review traces advances in sarcopenia research, emphasizing distinct Asian population characteristics and new pharmaceutical approaches. Findings show region-specific patterns of muscle decline that challenge universal diagnostic criteria, leading to Asian Working Group proposals. Prevalence ranges widely (10%–40%), is higher in key chronic diseases, and elevates fall and mortality risk. Management focuses on resistance exercise and nutrition, while >20 drug candidates progress in trials, supporting tailored future interventions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sarcopenia-in-the-era-of-precision-health-toward-personalized-interventions-for-healthy-longevity/436204/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sarcopenia-in-the-era-of-precision-health-toward-personalized-interventions-for-healthy-longevity/436204.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is sarcopenia and why is it important in older adults?","Question",{"text":113,"@type":114},"Sarcopenia is the progressive loss of skeletal muscle mass and function. It significantly impacts health outcomes by increasing risks such as falls and mortality and worsening overall health in older adults.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do diagnostic criteria for sarcopenia differ for Asian populations?",{"text":118,"@type":114},"Research indicates distinct muscle mass decline patterns in Asian adults, particularly women, which challenges applying global diagnostic criteria universally. The Asian Working Group for Sarcopenia proposed region-specific diagnostic criteria to reflect ethnic variations.",{"name":120,"@type":111,"acceptedAnswer":121},"What interventions are recommended for managing sarcopenia, and what pharmaceutical options are being developed?",{"text":122,"@type":114},"Current management emphasizes resistance exercise and nutritional interventions, including an advised daily protein intake of at least 1.2 g/kg. Pharmaceutical development includes myostatin inhibitors, selective androgen receptor modulators, ghrelin receptor agonists, mesenchymal stem cell therapy, and follistatin gene therapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},436204,1790729389,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","J Chin MedAssoc  \nReview ARticle  \nSarcopenia in the era of precision health: Toward personalized interventions for healthy longevity  \nLiang-Kung Chena,b,c,*  \naCenter for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cTaipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan, ROC  \nAbstract  \nSarcopenia, characterized by the progressive loss of skeletal muscle mass and function, significantly impacts health outcomes in older adults. This review explores the evolving landscape of sarcopenia research, with a particular focus on its unique characteristics in Asian populations and emerging pharmaceutical interventions. Recent studies have revealed distinct patterns of muscle mass decline in Asian adults, particularly in women, challenging the universal application of global sarcopenia diagnostic criteria. The Asian Working Group for Sarcopenia has proposed region-specific diagnostic criteria, acknowledging these ethnic variations. Prevalence estimates of sarcopenia vary widely, ranging from 10% to 40% in community-dwelling older adults. For specific chronic conditions, the prevalence of sarcopenia is notably higher, reaching 35% for cardiovascular diseases and 24.5% for chronic kidney disease. Sarcopenia is strongly associated with various chronic conditions, increasing the risk of falls by 1.5 to 3 times and significantly increasing mortality risk by 29% to 51% . Current management strategies primarily involve resistance exercise and nutritional interventions, with a recommended daily protein intake of at least 1.2g/kg to maintain muscle health. Pharmaceutical development has gained significant momentum, with over 20 compounds in various stages of clinical trials. These include myostatin inhibitors, selective androgen receptor modulators, ghrelin receptor agonists, mesenchymal stem cell therapy, and follistatin gene therapy. However, the unique dietary patterns, cultural contexts, and potentially distinct drug responses in Asian populations necessitate tailored interventions and Asiaspecific clinical trials. Future directions include refining Asian-specific diagnostic criteria, conducting large-scale epidemiological studies across multiple Asian countries, developing culturally appropriate interventions, integrating sarcopenia management into chronic disease care, and advancing pharmaceutical research with a focus on Asian populations. In conclusion, sarcopenia emerges as a critical nexus in the aging process, intricately linked with multiple organ systems and chronic conditions, underscoring the imperative for its recognition as a cornerstone in person-centered care and the holistic management of age-related health challenges.  \nKeywords: Aging; Androgen receptor; Ghrelin receptor; Pharmaceutical Research; Sarcopenia  \n980 [www.ejcma.org](www.ejcma.org)[ ](www.ejcma.org)\u003Cz10.1097/JCMA.0000000000001164>  \nReview Article. (2024) 87:11 J Chin MedAssoc  \n1. INTRODUCTION  \nPresbyopia, the age-related physiological decline characterized by progressive homeostatic disruption, manifests as a diminishing physiological reserve, weakening of organ function, and increased susceptibility to diseases, further compounded by heightened social vulnerability, all of which collectively contribute to a decline in functional independence and overall wellbeing in older adults.1–3 Notably, a key feature of presbyopiais the progressive and multifaceted alteration in body composition, manifested by a gradual loss of lean mass encompassing both skeletal muscle and bone mineral density, alongside a concerning increase in adipose tissue.4,5 These alterations transcend mere physiological shifts and often culminate in distinct pathological entities.6 Skeletal deterioration, characterized by osteoporosis, with its hallmark reduction in bone mineral density and elevated fra","cbCaifZR268ccnkk","https://ap.wps.com/l/cbCaifZR268ccnkk","pdf",731879,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What is sarcopenia and why is it important in older adults?\",\"answer\":\"Sarcopenia is the progressive loss of skeletal muscle mass and function. It significantly impacts health outcomes by increasing risks such as falls and mortality and worsening overall health in older adults.\"},{\"question\":\"How do diagnostic criteria for sarcopenia differ for Asian populations?\",\"answer\":\"Research indicates distinct muscle mass decline patterns in Asian adults, particularly women, which challenges applying global diagnostic criteria universally. The Asian Working Group for Sarcopenia proposed region-specific diagnostic criteria to reflect ethnic variations.\"},{\"question\":\"What interventions are recommended for managing sarcopenia, and what pharmaceutical options are being developed?\",\"answer\":\"Current management emphasizes resistance exercise and nutritional interventions, including an advised daily protein intake of at least 1.2 g/kg. Pharmaceutical development includes myostatin inhibitors, selective androgen receptor modulators, ghrelin receptor agonists, mesenchymal stem cell therapy, and follistatin gene therapy.\"}]","Sarcopenia in the era of precision health - Toward personalized interventions for healthy longevity | PDF",1790677145]