[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-373238-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-373238-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","sarcopenia-and-gastrointestinal-cancer-nutritional-approach-focusing-on-curcumin-supplementation-review","Sarcopenia and gastrointestinal cancer: nutritional approach focusing on curcumin supplementation - Review","","Sarcopenia is a muscle-wasting syndrome defined by progressive loss of skeletal muscle mass and strength, and it is clinically relevant when present in cancer patients. In gastrointestinal cancers, prevalent worldwide and in Brazil, nutritional risk is increased, making early screening and intervention essential. Evidence from turmeric/curcumin research suggests curcumin may reduce muscle depletion and oxidative stress while improving strength and fatigue, sarcopenia-related factors. The review synthesizes these connections and highlights curcumin supplementation as a potential adjuvant, while calling for further clinical studies to confirm efficacy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/sarcopenia-and-gastrointestinal-cancer-nutritional-approach-focusing-on-curcumin-supplementation-review/373238/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/sarcopenia-and-gastrointestinal-cancer-nutritional-approach-focusing-on-curcumin-supplementation-review/373238.png","ImageObject",300,407,{"name":42,"@type":43},"Jacob","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",17,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How is sarcopenia defined and what changed in EWGSOP2?","Question",{"text":63,"@type":64},"Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. EWGSOP2 emphasizes that decreased muscle strength is the main diagnostic characteristic and that both muscle quantity and quality are considered.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is the relationship between cancer and sarcopenia in clinical outcomes?",{"text":68,"@type":64},"When sarcopenia is associated with cancer, it correlates with poorer clinical outcomes. Cancer patients also have increased nutritional risk, requiring early detection and intervention.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is curcumin supplementation considered a potential adjuvant for cancer-related sarcopenia management?",{"text":72,"@type":64},"Curcumin has shown promise in reducing muscle depletion and oxidative stress and in improving strength and fatigue, which are factors related to sarcopenia. The review positions supplementation as a potential add-on to standard cancer and sarcopenia management, while noting the need for further studies.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},373238,1790563427,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| ORIGINAL ARTICLE |\n| --- |\n| NUTRITION |\n|  |\n| HIGHLIGHTS |\n| • Sarcopenia is a syndrome characterized by decreased strength, quantity and/or quality of skeletal muscle mass.\u003Cbr>• Sarcopenia when associated with cancer, it correlates with poorer clinical outcomes.\u003Cbr>• Curcumin has shown promise in reducing muscle depletion, oxidative stress, and improving strength and fatigue, factors related to sarcopenia.\u003Cbr>• Curcumin supplementation emerges as a potential adjuvant to the standard cancer treatment and sarcopenia management. |\n|  |\n| Received: 14 July 2024 Accepted: 15 November 2024 |\n| Declared conflict of interest of all authors: none\u003Cbr>Disclosure of funding:\u003Cbr>Coordenação de Aperfeiçoamentode Pessoal de Nível Superior, Brazil (CAPES), Finance Code 001. Declaration of use of artificial intelligence: none.\u003Cbr>Corresponding author. Nora Mnoukian Forones. E-mail:\u003Cbr>[nmforones@unifesp.br](nmforones@unifesp.br)\u003Cbr>Associate editor: Renata Furlan Viebig. |\n| |\n\n[doi.org/10.1590/S0004-2803.24612024-068](doi.org/10.1590/S0004-2803.24612024-068)  \nSarcopenia and gastrointestinal cancer: nutritional approach focusing on curcumin supplementation  \nPamela S de ALMEIDA, Katia BARÃO and Nora M FORONES*  \n* Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina, Divisão de Gastroenterologia, São Paulo, SP, Brasil.  \nABSTRACT – Sarcopenia is a syndrome characterized by decreased strength, quantity and/or quality of skeletal muscle mass. When associated with cancer, it correlates with poorer clinical outcomes. Cancers of the gastrointestinal tract, prevalent globally and in Brazil, are associated with a greater nutritional risk. Early detection and intervention for nutritional risks are critical in this population. Recent studies on turmeric/curcumin have demonstrated beneficial effects in cancer patients. Specifically, curcumin have shown promise in reducing muscle depletion, oxidative stress, and improving strength and fatigue, factors related to sarcopenia. This review aims to elucidate sarcopenia and sarcopenia secondary to cancer, emphasizing nutritional management and the role of curcumin supplementation. Effective cancer management, whether with or without sarcopenia, demands comprehensive public health strategies and multimodal interventions within healthcare institutions. Nutrition is pivotal across the cancer care journey, encompassing screening, guidance, and provision of nutrients that support maintaining or recovering body composition. Curcumin supplementation emerges as a potential adjuvant to the standard cancer treatment and sarcopenia management. Nevertheless, further clinical studies are warranted to substantiate these findings.  \nKeywords – Sarcopenia; cancer; curcumin; nutritional status.  \nArq Gastroenterol • 2025. v. 62:e24068  1/13   \nAlmeida PS, Barão K, Forones NM  \nSarcopenia and gastrointestinal cancer: nutritional approach focusing on curcumin supplementation  \nINTRODUCTION  \nThe European Working Group on Sarcopeniain Older People (EWGSOP) defined sarcopenia as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which can result in loss of function, worsening of quality of life, and death(1) . In 2019, the EWGSOP2 updated this definition, emphasizing that the decrease in muscle strength is considered the main characteristic of sarcopenia and a parameter for its diagnosis, which also considers not only the quantity but also the quality of muscle(2) .  \nSarcopenia is considered primary when it is originally associated with the aging process; and secondary when associated with physical inactivity, insufficient protein-energy intake, and chronic diseases, such as cancer. When it affects overweight and obese individuals, it is called Sarcopenic obesity(2-4) .  \nCancer is the second leading cause of early death around the world, both in wealthy and developing countries, accounting for 4.5 million (29 .8%) deaths. This is due to dem","cbCaitJI2SrkDIyb","https://ap.wps.com/l/cbCaitJI2SrkDIyb","pdf",232252,13,"English","# Introduction\n## Definitions and classification of sarcopenia\n## Cancer burden and nutritional risk\n## Cachexia, sarcopenia, and clinical implications\n## Prevalence gaps and study rationale","[{\"question\":\"How is sarcopenia defined and what changed in EWGSOP2?\",\"answer\":\"Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. EWGSOP2 emphasizes that decreased muscle strength is the main diagnostic characteristic and that both muscle quantity and quality are considered.\"},{\"question\":\"What is the relationship between cancer and sarcopenia in clinical outcomes?\",\"answer\":\"When sarcopenia is associated with cancer, it correlates with poorer clinical outcomes. Cancer patients also have increased nutritional risk, requiring early detection and intervention.\"},{\"question\":\"Why is curcumin supplementation considered a potential adjuvant for cancer-related sarcopenia management?\",\"answer\":\"Curcumin has shown promise in reducing muscle depletion and oxidative stress and in improving strength and fatigue, which are factors related to sarcopenia. The review positions supplementation as a potential add-on to standard cancer and sarcopenia management, while noting the need for further studies.\"}]","Sarcopenia and gastrointestinal cancer: nutritional approach focusing on curcumin supplementation - Review | PDF",1790198143,33]