[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-567831-105":59,"doc-detail-567831-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","sandimmunin-renal-transplantation-the-uk-experience-symposium-and-workshop","SANDIMMUNIN RENAL TRANSPLANTATION - The UK Experience - Symposium and Workshop","","SANDIMMUNIN RENAL TRANSPLANTATION: The UK Experience presents a 1984 symposium and workshop focused on cyclosporin in renal transplantation. The program outlines contributions from multiple UK centers and speakers, covering introductory framing, mechanisms of action, and clinical experiences with long-term and short-term cyclosporin strategies. Workshop sessions address appraisal topics such as dosage regimens, differential diagnosis between nephrotoxicity and rejection, and methods for biopsy, histopathology, monitoring, blood-level measurement, and drug interactions.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sandimmunin-renal-transplantation-the-uk-experience-symposium-and-workshop/567831/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sandimmunin-renal-transplantation-the-uk-experience-symposium-and-workshop/567831.png","ImageObject",300,407,{"name":92,"@type":93},"MrHarris58","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-13",true,{"@type":101,"interactionType":102,"userInteractionCount":4},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is the purpose of the symposium and workshop?","Question",{"text":111,"@type":112},"The introduction frames the meeting as primarily educational, aimed at discussing problems encountered in transplantation use of cyclosporin and identifying questions that need answers.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"Why is cyclosporin’s mechanism of action discussed?",{"text":116,"@type":112},"The program states that the mechanisms address both theoretical interest and the practical way the drug is used or might be used in clinical practice.",{"name":118,"@type":109,"acceptedAnswer":119},"What themes are covered in the workshop appraisal?",{"text":120,"@type":112},"The workshop sessions include dosage regimens and diagnostic considerations, specifically distinguishing nephrotoxicity from rejection, along with related assessment approaches such as biopsy, histopathology, monitoring, and blood-level measurement.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},567831,1791868138,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":128,"read_time":143},687212988360,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","SANDIMMUNIN RENAL TRANSPLANTATION  \nThe UK Experience  \nhttps://archive.org/details/sandimmuninrenal0000unse  \nSANDIMMUNIN RENAL TRANSPLANTATION  \nThe UK Experience  \nSymposium and WorkshopST ANDREWS 2-3 MARCH,1984  \nSandoz Pharmaceuticals98 The Centre,Feltham,Middlesex TW134EP  \nThe contributors  \nDr Colin Green Northwick Park HospitalMr RWG Johnson ManchesterMr Paul Lear LiverpoolProfessor PMorrisOxfordMr Keith RollesCambridgeProfessor J SalamanCardiffDr John SimpsonAberdeenDr Sathia ThiruCambridgeDr David WhiteCambridgeMr Richard Wood Oxford  \nSymposium  \nINTRODUCTION TO THE SYMPOSIUM5Professor P Morris  \nMECHANISMS OF ACTION OF CYCLOSPORIN7Dr Colin Green  \nTHE MANCHESTER EXPERIENCE WITH CYCLOSPORIN10Mr RWGJohnson  \nLONG-TERM CYCLOSPORIN THERAPY IN12RENAL TRANSPLANTATIONMr Paul Lear  \nSHORT-TERM CYCLOSPORIN FOLLOWED BY15CONVERSION TO CONVENTIONAL THERAPY:THE OXFORD TRIALSMr Richard Wood  \nTHE EUROPEAN MULTICENTRE TRIAL18Mr Keith Rolles  \nWorkshop  \n\n| WORKSHOP APPRAISAL   | 23   |\n| --- | --- |\n| Professor PMorris   |  |\n| DOSAGE REGIMENS   | 25   |\n| Professor PMorris;Mr RWG Johnson;Mr K Rolles;  \u003Cbr>Professor JSalaman;Mr RWood   |  |\n|  |  |\n| DIFFERENTIAL DIAGNOSIS:NEPHROTOXICITY OR REJECTION?   |  |\n| 1 FINE NEEDLE BIOPSY Mr Richard Wood   | 31   |\n| 2 HISTOPATHOLOGY Dr Sathia Thiru   | 33   |\n| 3 INTRARENAL PRESSURE MONITORING Professor J Salaman   | 40   |\n| 4 MEASUREMENT OF BLOOD LEVELS Dr David White   | 41   |\n| DRUG INTERACTIONS   |  |\n| 1 CLINICAL TRANSPLANTATION Dr David White   | 44   |\n| 2 ANIMAL STUDIES Dr John Simpson   | 46   |\n\nSymposium  \n# INTRODUCTIONTO THE SYMPOSIUM\n\nProfessor PMorris  \nThe meeting over today and tomorrow is not designed so much to heappraise on cyclosporin because we are all aware that it is an exciting newimmunosuppressive agent and is highly effective in suppressing graftrejection of a number of organs.It is meant to be,as I understand it,aneducational meeting where we are going to try and discuss the problemswith its use in transplantation and perhaps identify the questions that needto be answered.Now Iam not optimistic enough to feel that we are goingto answer many of the questions that are going to be posed this afternoonand tomorrow morning,but at least if we can go some way to identifyingthe questions that arise from the problems that you will hear about,thiswill be a step forward.  \nNow again I am aware that many of you are just starting to usecyclosporin or are about to use cyclosporin,which is really the reason forthe organisation of this meeting by Sandoz;namely to let you know whatthe problems are and how people are trying to deal with these at thepresent time.This is a small and informal meeting and I hope that every-one remembers that;in particular I would ask the speakers and the audi-ence to resist the temptation to score points against one another which isalways a temptation at such a gathering as this,and remember that we aretrying to actually identify some of the problems and some of the questionsthat need to be answered.  \nI am firstly going to ask Colin Green to speak and I have changed thetitle from the one given in the programme.I have now asked him to talk onmechanisms of action of cyclosporin.Originally it was planned that Iwould say something about this but then when we saw what Colin hadbeen left with,it seemed really an impossible task for him to talk about theexperimental development of cyclosporin without discussing mechan-isms,which he is going to do over the next 20 minutes or so.I think thatthis is not only of theoretical interest but bears considerable relationship tothe way we use the drug or might attempt to use it,in clinical practice.Thus this is a very important opening address for this afternoon.  \n#  Symposium \n\nThen we are going on to look at its use clinically in twounits that have avery large experience with the long-term use of cyclosporin,namely Man-chester and Liverpool,and then,after tea,we are going to talk about theshort-term use of th","cbCaiaRCnvgyW4kB","https://ap.wps.com/l/cbCaiaRCnvgyW4kB","pdf",3474827,52,"English","# INTRODUCTION TO THE SYMPOSIUM\n## Symposium\n# MECHANISMS OF ACTION OF CYCLOSPORIN\n## Symposium","[{\"question\":\"What is the purpose of the symposium and workshop?\",\"answer\":\"The introduction frames the meeting as primarily educational, aimed at discussing problems encountered in transplantation use of cyclosporin and identifying questions that need answers.\"},{\"question\":\"Why is cyclosporin’s mechanism of action discussed?\",\"answer\":\"The program states that the mechanisms address both theoretical interest and the practical way the drug is used or might be used in clinical practice.\"},{\"question\":\"What themes are covered in the workshop appraisal?\",\"answer\":\"The workshop sessions include dosage regimens and diagnostic considerations, specifically distinguishing nephrotoxicity from rejection, along with related assessment approaches such as biopsy, histopathology, monitoring, and blood-level measurement.\"}]","SANDIMMUNIN RENAL TRANSPLANTATION - The UK Experience - Symposium and Workshop | PDF",131]