[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-410380-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-410380-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","safety-profile-of-warfarin-and-apixaban-for-deep-vein-thrombosis-in-patients-with-chronic-kidney-disease","Safety Profile of Warfarin and Apixaban for Deep Vein Thrombosis in Patients With Chronic Kidney Disease","","Chronic kidney disease (CKD) increases susceptibility to bleeding complications and thromboembolic events, while guidance on the most suitable anticoagulant for CKD patients with deep vein thrombosis (DVT) remains limited. This descriptive comparative study estimated the proportion of bleeding episodes linked to apixaban versus warfarin in CKD patients with DVT, aiming to address the knowledge gap and support safer, more effective treatment selection. Outcomes assessed bleeding tendencies and renal function worsening.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/safety-profile-of-warfarin-and-apixaban-for-deep-vein-thrombosis-in-patients-with-chronic-kidney-disease/410380/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/safety-profile-of-warfarin-and-apixaban-for-deep-vein-thrombosis-in-patients-with-chronic-kidney-disease/410380.png","ImageObject",300,407,{"name":42,"@type":43},"Connor ","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main goal of the study?","Question",{"text":63,"@type":64},"To compare the safety profiles of warfarin and apixaban for DVT in patients with CKD by focusing on bleeding risk and renal function worsening.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the study designed and who were the participants?",{"text":68,"@type":64},"A descriptive comparative study was conducted at Mayo Hospital, Lahore, between September 17, 2022 and September 16, 2024. Male and female CKD patients aged 30 to 70 diagnosed with DVT were enrolled after starting warfarin or apixaban.",{"name":70,"@type":61,"acceptedAnswer":71},"Which drug showed fewer serious bleeding episodes, and was the difference statistically significant?",{"text":72,"@type":64},"The apixaban group experienced fewer fatal and major bleeding episodes than the warfarin group. However, the differences were not statistically significant based on the reported p-values.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},410380,1790716665,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},687207022233,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review began 11/11/2025  \nReview ended 11/26/2025  \nPublished 12/01/2025  \n© Copyright 2025  \nKausar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98274  \nOpen Access Original Article  \nSafety Profile of Warfarin and Apixaban for Deep Vein Thrombosis in Patients With Chronic Kidney Disease  \nFatima Kausar 1 , Osama Nadeem 2, 3 , Alina Khalil 4 , Sajjad Ahmad 5, Wajid Ali 6  \n1. Nephrology, Mayo Hospital, Lahore, PAK 2. General Internal Medicine, North Manchester General Hospital, Manchester, GBR 3. General Medicine, Mayo Hospital, Lahore, PAK 4. Medicine, Shalamar Hospital, Lahore, PAK 5. Internal Medicine, District Headquarters Hospital Timergara, Dir, PAK 6. Surgery, Hayatabad Medical Complex Peshawar, Peshawar, PAK  \nCorresponding author: Osama Nadeem, [osama.nadeem58@gmail.com](osama.nadeem58@gmail.com)  \nAbstract  \nBackground  \nPatients with chronic kidney disease (CKD) are more susceptible to bleeding complications and thromboembolic events. Current recommendations provide limited guidance on the optimal anticoagulant for CKD patients with deep vein thrombosis (DVT) . Therefore, this study was planned. By estimating the proportion of bleeding episodes associated with apixaban and warfarin in CKD patients, this study aimed to address this knowledge gap and assist physicians in selecting safer and more effective treatment options.  \nObjective  \nThe objective of this study is to compare the safety profiles of warfarin and apixaban for DVT in patients with CKD.  \nMethods  \nThis descriptive comparative study was conducted at the Department of General Internal Medicine, Mayo Hospital, Lahore, Pakistan, from September 17, 2022, to September 16, 2024. Male and female patients aged  \n30 to 70 years with CKD, diagnosed with DVT, and started on warfarin or apixaban were enrolled. A total of  \n228 patients were included, with 114 in the apixaban group and 114 in the warfarin group. Patients were compared for the safety profiles of both drugs, assessed in terms of bleeding tendencies and worsening renal function. Data analysis was performed using IBM SPSS Statistics for Windows, Version 26.0 (Released 2018; IBM Corp., Armonk, NY, USA) .  \nResults  \nThe overall mean age of participants was 52 years. The mean age in the apixaban group was 54.73 ± 12.17 years, and in the warfarin group, it was 49.99 ± 12.14 years. Mean CKD duration in the apixaban and warfarin groups was 8.55 ± 2.14 years and 9 .46 ± 2.73 years, respectively. Overall, 159 participants (69 . 7%) were male, with 80 (70 .2%) in the apixaban group and 79 (69 .3%) in the warfarin group. Participants over 50 years of age totaled 116 (50 .9%), with 69 (60 .5%) in the apixaban group and 47 (41 .2%) in the warfarin group. Overall, 16 patients (7.0%) experienced a fatal bleed, including five (4 .4%) in the apixaban group and 11 (9 .6%) in the warfarin group. Major bleeding occurred in 16 patients (14 .0%) receiving apixaban and 19 (16 . 7%) receiving warfarin. The chi-square p-values for differences in fatal bleed, major bleed, and minor or no bleed between apixaban and warfarin were 0.120, 0.582, and 0 .153, respectively.  \nConclusions  \nThis study provided valuable information regarding the safety profile of warfarin and apixaban for DVT in individuals with CKD. The apixaban group experienced fewer fatal bleeding episodes than the warfarin group. Similarly, serious bleeding episodes were less frequent with apixaban compared with warfarin. However, there was no statistically significant difference between the two treatment groups. The study findings imply that apixaban might be a safer option than warfarin for anticoagulation in patients with CKD, but, due to the lack of statistical significance and the restriction of the study to a single center, f","cbCainrauENjCIkq","https://ap.wps.com/l/cbCainrauENjCIkq","pdf",151716,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusions\n# Introduction\n# How to cite this article\n# Keywords","[{\"question\":\"What is the main goal of the study?\",\"answer\":\"To compare the safety profiles of warfarin and apixaban for DVT in patients with CKD by focusing on bleeding risk and renal function worsening.\"},{\"question\":\"How was the study designed and who were the participants?\",\"answer\":\"A descriptive comparative study was conducted at Mayo Hospital, Lahore, between September 17, 2022 and September 16, 2024. Male and female CKD patients aged 30 to 70 diagnosed with DVT were enrolled after starting warfarin or apixaban.\"},{\"question\":\"Which drug showed fewer serious bleeding episodes, and was the difference statistically significant?\",\"answer\":\"The apixaban group experienced fewer fatal and major bleeding episodes than the warfarin group. However, the differences were not statistically significant based on the reported p-values.\"}]","Safety Profile of Warfarin and Apixaban for Deep Vein Thrombosis in Patients With Chronic Kidney Disease | PDF",1790585125,23]