[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-213031-en":3,"doc-seo-213031-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},213031,2336474459895,"Gloria","https://ap-avatar.wpscdn.com/avatar/22000baeef7a5ed0655?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786071322749376916",8,"Research & Report","Sacral and Implantable Tibial Neuromodulation for the Management of Overactive Bladder - A Systematic Review and Meta-analysis","Implantable tibial neuromodulation (iTNM) systems have recently become commercially available in the US and provide a neurostimulation option for overactive bladder (OAB). In the absence of head-to-head trials, this meta-analysis indirectly compared the efficacy and safety of sacral neuromodulation (SNM) and iTNM for OAB. Searches used terms for OAB and neuromodulation. Twenty studies (1416 SNM, 350 iTNM) used single-arm evidence to assess urgency urinary incontinence, OAB response, device-related adverse events, and quality-of-life outcomes.","Adv Ther (2025) 42:10–35  \n[https://doi.org/10.1007/s12325-024-03019-0](https://doi.org/10.1007/s12325-024-03019-0)  \nREVIEW  \nSacral and Implantable Tibial Neuromodulation for the Management of Overactive Bladder: A Systematic Review and Meta‑analysis  \nCindy L. Amundsen · Suzette E. Sutherland · Stephanie J. Kielb · Roger R. Dmochowski  \nReceived: August 22, 2024 / Accepted: October 2, 2024 / Published online: October 30, 2024 © The Author(s) 2024  \nABSTRACT  \nIntroduction: Implantable tibial neuromodulation (iTNM) systems have recently become commercially available in the US, and offer a new method of neurostimulation for the treatment of overactive bladder (OAB). In the absence of headto-head studies, the aim of this meta-analysis was to indirectly compare the efficacy and safety of sacral neuromodulation (SNM) and implantable tibial neuromodulation (iTNM) for the treatment of OAB.  \nMethods: A comprehensive search was performed using terms for OAB and neuromodulation.  \nSupplementary Information The online version contains supplementary material available at [https://doi.org/10.1007/s12325-024-03019-0](https://doi.org/10.1007/s12325-024-03019-0) .  \nC. L. Amundsen (*)  \nDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetricsand Gynecology, Duke University, Durham, NC, USA  \ne-mail: [cindy.amundsen@duke.edu](cindy.amundsen@duke.edu)  \nS. E. Sutherland  \nArizona Urology Specialists/United Urology Group, Scottsdale, AZ, USA  \nS. J. Kielb  \nDepartment of Urology, University of Michigan, Ann Arbor, MI, USA  \nR. R. Dmochowski  \nBlueWind Medical, Inc, Park City, UT, USA  \nPrimary efficacy measures included a ≥ 50% reduction in urgency urinary incontinence (UUI) episodes, urinary frequency, and/or OAB symptoms. Primary safety measures included the rate of device-related adverse events (AEs).  \nResults: A total of 20 studies met selection criteria, encompassing 1416 patients treated with SNM and 350 patients treated with iTNM. No comparative or placebo-controlled studies for SNM and iTNM were identified, and therefore the analysis was completed using single-arm results. Weighted averages showed that the UUI responder rate was similar for both SNM and iTNM (71.8% and 71.3%, respectively) . Similarly, weighted averages of OAB responder rates were 73.9% for SNM and 79.4% for iTNM. Similar rates of device-related AEs were also observed. Conclusions: This meta-analysis found similar efficacy and safety of SNM and iTNM for the treatment of OAB and UUI, including UUI and OAB symptom response rates, reduction in UUI episodes, significant improvements in quality-oflife (QoL), and low rates of procedure and devicerelated adverse events. Notably, this comparable efficacy was seen without the use of a trial phase of neuromodulation in the iTNM studies versus SNM studies.  \nKeywords: Implantable neurostimulators; Meta-analysis; Systematic review; Urinary bladder; Overactive; Urinary incontinence; Urge; Sacral neuromodulation; Tibialneuromodulation  \nKey Summary Points  \nWhy carry out this study?  \nIn the past two years, implantable tibial neuromodulation (iTNM) systems have become available in the US, offering a less invasive implantable neuromodulation treatment option for overactive bladder (OAB) and its significant impact on quality of life.  \nThis analysis indirectly compares the clinical efficacy and safety of iTNM with sacral neuromodulation (SNM), the most common implantable neuromodulation option for OAB treatment, to provide healthcare providers and patients with additional decisionmaking information.  \nWhat was learnedfrom this study?  \nThis analysis demonstrated that iTNM appears to have similar efficacy and safety to SNM, offering patients with OAB a valuable additional treatment choice.  \nIn the future, randomized comparative studies will be important to further establish similarities and differences in efficacy and safety between iTNM and SNM.  \nINTRODUCTION  \nOveractive bladder (OAB) affects million","cbCaieUPkAWyXA8D","https://ap.wps.com/l/cbCaieUPkAWyXA8D","pdf",3770163,1,26,"English","en",105,"# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusions\n# Key Summary Points\n## Why carry out this study?\n## What was learned from this study?\n# Introduction","[{\"question\":\"What was the aim of this meta-analysis for OAB treatment?\",\"answer\":\"To indirectly compare the efficacy and safety of sacral neuromodulation (SNM) versus implantable tibial neuromodulation (iTNM) for overactive bladder when no head-to-head studies were available.\"},{\"question\":\"How many studies and patients were included, and how was the analysis performed?\",\"answer\":\"Twenty studies met inclusion criteria, covering 1416 patients treated with SNM and 350 treated with iTNM. No comparative or placebo-controlled SNM vs iTNM studies were found, so the meta-analysis relied on single-arm results.\"},{\"question\":\"What did the results show about efficacy and safety between SNM and iTNM?\",\"answer\":\"UUI responder rates were similar (71.8% for SNM vs 71.3% for iTNM), and OAB responder rates were comparable (73.9% vs 79.4%). Device-related adverse event rates were also similar, supporting broadly comparable efficacy and safety.\"}]","Sacral and Implantable Tibial Neuromodulation for the Management of Overactive Bladder - A Systematic Review and Meta-analysis | PDF",1788752582,66,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"sacral-and-implantable-tibial-neuromodulation-for-the-management-of-overactive-bladder-a-systematic-review-and-meta-analysis","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/research-report/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/sacral-and-implantable-tibial-neuromodulation-for-the-management-of-overactive-bladder-a-systematic-review-and-meta-analysis/213031/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-09-11","2026-09-07",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"What was the aim of this meta-analysis for OAB treatment?","Question",{"text":76,"@type":77},"To indirectly compare the efficacy and safety of sacral neuromodulation (SNM) versus implantable tibial neuromodulation (iTNM) for overactive bladder when no head-to-head studies were available.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"How many studies and patients were included, and how was the analysis performed?",{"text":81,"@type":77},"Twenty studies met inclusion criteria, covering 1416 patients treated with SNM and 350 treated with iTNM. No comparative or placebo-controlled SNM vs iTNM studies were found, so the meta-analysis relied on single-arm results.",{"name":83,"@type":74,"acceptedAnswer":84},"What did the results show about efficacy and safety between SNM and iTNM?",{"text":85,"@type":77},"UUI responder rates were similar (71.8% for SNM vs 71.3% for iTNM), and OAB responder rates were comparable (73.9% vs 79.4%). Device-related adverse event rates were also similar, supporting broadly comparable efficacy and safety.","https://schema.org",{"og:url":52,"og:type":88,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":90,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":93},[94,98,102,106,111,116,121,124,129,132,136],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":95,"show_sort_weight":96,"slug":97},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":99,"show_sort_weight":100,"slug":101},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":103,"show_sort_weight":104,"slug":105},"Exam",70,"exam",{"id":107,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":109,"slug":110},5,"Comic",60,"comic",{"id":112,"doc_module":4,"doc_module_name":46,"category_name":113,"show_sort_weight":114,"slug":115},6,"Technology",50,"technology",{"id":117,"doc_module":4,"doc_module_name":46,"category_name":118,"show_sort_weight":119,"slug":120},7,"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":122,"slug":123},30,"research-report",{"id":125,"doc_module":4,"doc_module_name":46,"category_name":126,"show_sort_weight":127,"slug":128},9,"Religion & Spirituality",20,"religion-spirituality",{"id":127,"doc_module":4,"doc_module_name":46,"category_name":130,"show_sort_weight":127,"slug":131},"World Cup","world-cup",{"id":133,"doc_module":4,"doc_module_name":46,"category_name":134,"show_sort_weight":133,"slug":135},10,"Lifestyle","lifestyle",{"id":137,"doc_module":4,"doc_module_name":46,"category_name":138,"show_sort_weight":107,"slug":139},19,"General","general"]