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Long non-coding RNAs (lncRNAs) regulate gene expression and tumor progression, yet the functional diversity of RP11-derived lncRNAs—mapped to Roswell Park Cancer Institute bacterial artificial chromosome (BAC) clones—has only recently gained attention. This mini-review synthesizes current evidence on RP11-derived lncRNAs in HCC, covering genomic origins, molecular mechanisms, biological significance, and their diagnostic and prognostic potential in tissue and serum, and outlining therapeutic opportunities and future translational directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rp11-derived-long-non-coding-rnas-in-hepatocellular-carcinoma-hidden-treasures-in-plain-sight/445223/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rp11-derived-long-non-coding-rnas-in-hepatocellular-carcinoma-hidden-treasures-in-plain-sight/445223.png","ImageObject",300,407,{"name":92,"@type":93},"pixelkiddo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are RP11-derived lncRNAs in the context of HCC?","Question",{"text":112,"@type":113},"RP11-derived lncRNAs are long non-coding RNA transcripts that originate from BAC clones mapped from the Roswell Park Cancer Institute (RPCI) libraries, with functions that can vary by cellular context in hepatocellular carcinoma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do RP11-derived lncRNAs influence cancer biology?",{"text":117,"@type":113},"They are discussed as regulators of gene expression and cancer progression, including roles in metabolic reprogramming, microRNA network modulation, and tumor progression.",{"name":119,"@type":110,"acceptedAnswer":120},"What clinical value and future directions are proposed for RP11-derived lncRNAs?",{"text":121,"@type":113},"The review highlights diagnostic and prognostic relevance in tissue and serum analyses, and it proposes therapeutic opportunities and future work to translate RP11-derived lncRNAs into actionable biomarkers and precision therapy targets for liver cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},445223,1791048557,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},962090883892,"https://ap-avatar.wpscdn.com/avatar/e00115db34f3e0f11b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1790152879550218658","Tech Science Press  \n| Doi:10.32604/or.2025.072240\u003Cbr>REVIEW | \u003Cbr>|\n| --- | --- |\n| RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma: Hidden Treasures in Plain Sight\u003Cbr>Se Ha Jang1,2,\\#, Hyung Seok Kim3,\\# and Jung Woo Eun1, *\u003Cbr>1 Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea\u003Cbr>2 Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea\u003Cbr>3 Department of Biochemistry, Kosin University College of Medicine, Seo-gu, Busan, 49267, Republic of Korea\u003Cbr>*Corresponding Author: [Jung Woo Eun. Email: jetaimebin@gmail.com](Jung Woo Eun. Email: jetaimebin@gmail.com)\u003Cbr>\\# These authors contributed equally to this work\u003Cbr>Received: 22 August 2025; Accepted: 30 October 2025; Published: 30 December 2025\u003Cbr>ABSTRACT: Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and prognostic value in tissue and serum-based analyses. Finally, we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.\u003Cbr>KEYWORDS: Hepatocellular carcinoma; long non-coding RNA; RP11-derived lncRNA; biomarker; therapeutic target |  |\n\n1 Introduction  \nLong non-coding RNAs (lncRNAs)—transcripts longer than 200 nucleotides with no protein-coding potential—are key regulators of gene expression. They function through chromatin remodeling, transcriptional and post-transcriptional regulation, and interactions with proteins and other RNAs [1]. A particularly large family of lncRNAs carries the “RP” prefix, which denotes transcripts originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute (RPCI) libraries during the Human Genome Project [2,3]. In our compendium of total gene entries, 10,430 bear RP designations (≈17%); among these, the RP11 subset is the largest single group. RP11-derived lncRNAs are heterogeneous in origin and function, with members reported to act as oncogenes or tumor suppressors depending on cellular context [4–6] .  \nWhile numerous RP11-derived lncRNAs are implicated in hepatocellular carcinoma (HCC), prior reviews have either addressed lncRNAs broadly or focused on other functional subclasses. Accordingly, this review provides the first critical synthesis dedicated specifically to the RP11 family in HCC. Moving beyond a simple catalog, our primary goal is to identify and analyze the convergent molecular mechanisms that unify  \nCopyright © 2026 The Authors. Published by Tech Science Press.  \nThis work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nthe roles of these diverse transcripts. By evaluating the evidence from this focused perspective, we aim to establish a conceptual framework for prioritizing the most clinically and functionally relevant RP11 lncRNAsas biomarkers and therapeutic targets.  \n2 RP11 lncRNAs: Origins and Classification  \nThe “RP” naming convention originated during the clone-based phase of the Human Genome Project, when the Roswell Park Cancer Institute constructed","cbCaiq2Dc4t9jKax","https://ap.wps.com/l/cbCaiq2Dc4t9jKax","pdf",2827910,16,"English","# Introduction\n# RP11 lncRNAs: Origins and Classification","[{\"question\":\"What are RP11-derived lncRNAs in the context of HCC?\",\"answer\":\"RP11-derived lncRNAs are long non-coding RNA transcripts that originate from BAC clones mapped from the Roswell Park Cancer Institute (RPCI) libraries, with functions that can vary by cellular context in hepatocellular carcinoma.\"},{\"question\":\"How do RP11-derived lncRNAs influence cancer biology?\",\"answer\":\"They are discussed as regulators of gene expression and cancer progression, including roles in metabolic reprogramming, microRNA network modulation, and tumor progression.\"},{\"question\":\"What clinical value and future directions are proposed for RP11-derived lncRNAs?\",\"answer\":\"The review highlights diagnostic and prognostic relevance in tissue and serum analyses, and it proposes therapeutic opportunities and future work to translate RP11-derived lncRNAs into actionable biomarkers and precision therapy targets for liver cancer.\"}]","RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma - Hidden Treasures in Plain Sight | PDF",1790710751]