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The study designs RSV-HY-NE by incorporating an active oil blend (tea tree oil, baobab oil, and sesame oil) into a hyaluronic acid-based hydrogel matrix. Formulations are produced and optimized using the Box–Behnken statistical design, then evaluated for stability, droplet size, drug release, antibacterial/antifungal activity, and ex-vivo penetration performance. Results demonstrate nanoscale droplet sizes and synergistic improvements in wound closure and antimicrobial effectiveness versus comparator systems.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rosuvastatin-natural-oil-self-nanosized-emulsion-incorporated-into-hyaluronic-acid-based-hydrogel-for-wound-healing/156195/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rosuvastatin-natural-oil-self-nanosized-emulsion-incorporated-into-hyaluronic-acid-based-hydrogel-for-wound-healing/156195.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-08-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What delivery system is developed for wound healing in the study?","Question",{"text":113,"@type":114},"A rosuvastatin-loaded self-nanosized emulsion (RSV-HY-NE) is incorporated into a hyaluronic acid-based hydrogel using an active oil blend of tea tree, baobab, and sesame oils.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How are the RSV-HY-NE formulations created and optimized?",{"text":118,"@type":114},"The formulations are created and optimized using the Box–Behnken statistical pattern, followed by assessment of stability index and droplet size.",{"name":120,"@type":111,"acceptedAnswer":121},"What wound-healing and antimicrobial advantages are reported for the optimal formulation?",{"text":122,"@type":114},"The optimal formulation shows an ~8-fold reduction in mean wound width versus plain hyaluronic acid aqueous dispersion, increased RSV penetration versus RSV aqueous dispersion, and enhanced inhibition zones against Candida albicans and Staphylococcus aureus compared with comparator oil-phase systems.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},156195,1787954826,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":130,"read_time":144},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Journal of Pharmaceutical Innovation (2026) 21:258 [https://doi.org/10.1007/s12247-026-10463-8](https://doi.org/10.1007/s12247-026-10463-8)  \nRESEARCH  \nRosuvastatin‒Natural Oil Self Nanosized Emulsion Incorporated into Hyaluronic Acid‒Based Hydrogel for Wound Healing  \nFayroz M. Shazly1 · Khaled M Hosny1 · Rasha A. Khallaf2,3 · Shaimaa A. Mahmoud4 · Walaa A. Abualsunun1 · Abdulmajeed M. Jali5 · Rawan Bafail2 · Mohammed Baradwan6 · Ahmed K. Kammoun6 · Majed A Alghamdi1 · Sherif El Saadany1  \nReceived: 17 October 2025 / Accepted: 7 February 2026 / Published online: 5 March 2026  \n© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026  \nAbstract  \nPurpose Remodeling damaged tissues and managing infection are two crucial steps in the intricate process of the healing of chronic wounds. The present work aims to develop and enhance a rosuvastatin-loaded self-nanoemulsifying drug delivery system utilizing an active oil blend (i.e., tea tree oil, baobab oil, and sesame oil) and hyaluronic acid (RSV-HY-NE) . Methods The RSV-HY-NE was created and optimized utilizing the Box‒Behnken statistical pattern. The formulations’ stability index and their droplet size were evaluated. The ideal formulation’s capacities to heal wounds, fight bacteria and fungi, release RSV, and exhibit ex-vivo penetration were also investigated.  \nResults The droplet size of the generated nanoemulsion ranged from 25 to 327 nm. The results of the trial validated the significant synergistic effect of RSV, HY, and the active oil mixture on induced wound healing; the combination had better antibacterial and antifungal properties than earlier systems, as well as improved wound closure. The optimal formulation demonstrated an 8-fold reduction in mean wound width in comparison with a plain HY aqueous dispersion, a 5.55-fold increase in RSV penetration compared with an RSV aqueous dispersion, and a 3.4-and 3.5-fold increase in the inhibitory zone against Candida albicans and Staphylococcus aureus, respectively, compared with an oil phase containing oleic acid without the active oil mixture.  \nConclusion The developed nanoemulsions containing RSV, HY, tea tree oil, baobab oil, and sesame oil may prove to be effective paradigms for treating injuries, with enhanced antibacterial and antifungal properties.  \nKeywords Nanoemulsion · Box‒Behnken design · Antimicrobial effect · Rosuvastatin, essential oils  \n􀀍 RashaA. Khallaf  \n[rasha_khallaf@yahoo.com](rasha_khallaf@yahoo.com); [ramahmoud@Taibahu.edu.sa](ramahmoud@Taibahu.edu.sa)[ ](ramahmoud@Taibahu.edu.sa)[Fayroz M. Shazly](Fayroz M. Shazly)  \n[dr.fairose@hotmail.com](dr.fairose@hotmail.com)  \nKhaled M Hosny  \n[kmhomar@kau.edu.sa](kmhomar@kau.edu.sa)  \nShaimaaA. Mahmoud  \n[hrkingschool@gmail.com](hrkingschool@gmail.com)  \nWalaaA. Abualsunun  \n[wabuassonon@kau.edu.sa](wabuassonon@kau.edu.sa)  \n[Abdulmajeed M. Jali](Abdulmajeed M. Jali)  \n[amjali@jazanu.edu.sa](amjali@jazanu.edu.sa)  \nRawan Bafail  \n[rbafail@taibahu.edu.sa](rbafail@taibahu.edu.sa)  \nMohammed Baradwan  \n[mbaradwan@kau.edu.sa](mbaradwan@kau.edu.sa)  \nAhmed K. Kammoun  \n[Akammoun@kau.edu.sa](Akammoun@kau.edu.sa)  \nMajed AAlghamdi  \n[Magalgamdi@kau.edu.sa](Magalgamdi@kau.edu.sa)  \nSherifEl Saadany  \n[Selsaadany@kau.edu.sa](Selsaadany@kau.edu.sa)  \n1 Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia  \n2 Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Medina, Saudi Arabia  \n3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt  \n4 Department of Chemical Laboratories, Ajiad Laboratories, Jeddah, Saudi Arabia  \n5 Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia  \n6 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia  \nIntroduction  \nBurns","cbCaioP1sdnQH2zk","https://ap.wps.com/l/cbCaioP1sdnQH2zk","pdf",2064836,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Chronic wound healing and infection control\n## Statins and rosuvastatin in tissue repair\n## Rationale for nanoemulsions","[{\"question\":\"What delivery system is developed for wound healing in the study?\",\"answer\":\"A rosuvastatin-loaded self-nanosized emulsion (RSV-HY-NE) is incorporated into a hyaluronic acid-based hydrogel using an active oil blend of tea tree, baobab, and sesame oils.\"},{\"question\":\"How are the RSV-HY-NE formulations created and optimized?\",\"answer\":\"The formulations are created and optimized using the Box–Behnken statistical pattern, followed by assessment of stability index and droplet size.\"},{\"question\":\"What wound-healing and antimicrobial advantages are reported for the optimal formulation?\",\"answer\":\"The optimal formulation shows an ~8-fold reduction in mean wound width versus plain hyaluronic acid aqueous dispersion, increased RSV penetration versus RSV aqueous dispersion, and enhanced inhibition zones against Candida albicans and Staphylococcus aureus compared with comparator oil-phase systems.\"}]","Rosuvastatin - Natural Oil Self Nanosized Emulsion Incorporated into Hyaluronic Acid - Based Hydrogel for Wound Healing | PDF",48]