[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-459882-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-459882-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","romosozumab-enhances-implant-stability-in-glucocorticoid-induced-osteoporotic-bone-a-rabbit-model-study","Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone - A Rabbit Model Study","","Implant fixation in osteoporotic bone is difficult because reduced bone mass and impaired microarchitecture undermine screw stability. This rabbit model study evaluated whether romosozumab, a sclerostin inhibitor, improves osseointegration and mechanical stability of cancellous bone screws under glucocorticoid-induced osteoporosis. Fifty-five rabbits received glucocorticoid-based osteoporosis induction and were treated across control, osteoporosis, PTH, PTH plus denosumab, and romosozumab groups, followed by histomorphometry and biomechanical pull-out testing to assess fixation performance.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/romosozumab-enhances-implant-stability-in-glucocorticoid-induced-osteoporotic-bone-a-rabbit-model-study/459882/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/romosozumab-enhances-implant-stability-in-glucocorticoid-induced-osteoporotic-bone-a-rabbit-model-study/459882.png","ImageObject",300,407,{"name":42,"@type":43},"Pentious","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What problem does the study address in osteoporotic bone implants?","Question",{"text":63,"@type":64},"Osteoporotic bone has reduced mass and compromised microarchitecture, which limits primary stability and increases the risk of implant failure.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was osteoporosis induced in the rabbit model?",{"text":68,"@type":64},"Osteoporosis was induced using either bilateral ovariectomy or weekly intramuscular glucocorticoid injections, with glucocorticoid injection selected based on bone mineral density results.",{"name":70,"@type":61,"acceptedAnswer":71},"What outcomes were used to evaluate implant performance?",{"text":72,"@type":64},"Bone-to-implant contact and bone area fraction occupancy were assessed by histomorphometry, and mechanical pull-out strength was measured at 1-mm displacement.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},459882,1790974889,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},1374404730887,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Neurospine 2025;22(4):880-890. [https://doi.org/10.14245/ns.2550774.387](https://doi.org/10.14245/ns.2550774.387)  \nNeurospine  \npISSN 2586-6583 eISSN 2586-6591  \nOriginal Article  \nCorresponding Author  \nByung Ho Lee  \n [https://orcid.org/0000-0001-7235-4981](https://orcid.org/0000-0001-7235-4981)  \nDepartment of Orthopedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea  \n[Email: bhlee96@yuhs.ac](Email: bhlee96@yuhs.ac)  \nReceived: May 29, 2025  \nRevised: July 16, 2025  \nAccepted: July 26, 2025  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://creativecom](https://creativecom)[mons.org/licenses/by-nc/4.0/](mons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nCopyright © 2025 by the Korean Spinal Neurosurgery Society  \nRomosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study  \nJi-Won Kwon, Seong-Hwan Moon, Kyung-Soo Suk, Si Young Park, Hak-Sun Kim, Sub-Ri Park, Namhoo Kim, Byung Ho Lee  \nDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea  \nObjective: Implant fixation in osteoporotic bone presents substantial challenges due to reduced bone mass and compromised microarchitecture. This study investigated whether romosozumab, a sclerostin inhibitor, improves osseointegration and mechanical stability of cancellous bone screws in glucocorticoid-induced osteoporosis .  \nMethods: Fifty-five New Zealand white rabbits were enrolled. Osteoporosis was induced via either bilateral ovariectomy or weekly intramuscular glucocorticoid injections (4–8 mg/kg) . Based on bone mineral density results, glucocorticoid injection was selected for experimental induction . Rabbits were divided into 5 groups: control, untreated osteoporosis, parathyroid hormone (PTH), PTH combined with denosumab, and romosozumab. Cancellous bone screws (4.0-mm diameter, titanium alloy) were bilaterally inserted into the iliac bones . Antiosteoporosis treatments were administered for 3-week postimplantation . Histomorphometric evaluation of bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) was performed using nondecalcified sectioning and Goldner trichrome staining. Biomechanical pull-out testing measured resistance at 1-mm displacement using a standardized setup on the MTS system .  \nResults: The romosozumab-treated group exhibited superior outcomes. BIC reached 21.2% ± 18.1%, and BAFO was 56.9% ± 9.9%. Pull-out strength significantly increased to 275 ± 55 Nin the romosozumab group, outperforming PTH (184 ± 61 N), PTH+denosumab (202 ± 23 N), and untreated osteoporosis (120 ± 33 N) . Enhanced collagen structure and neobone formation were observed histologically around implants.  \nConclusion: Romosozumab significantly enhances cancellous bone screw fixation strength and osseointegration in glucocorticoid-induced osteoporotic bone . These findings suggest its clinical potential as an adjuvant therapy in improving spinal implant outcomes in osteoporotic patients.  \nKeywords: Glucocorticoid, Implant, Osteoporosis, Romosozumab, Rabbit  \nINTRODUCTION  \nOsteoporosis, a systemic skeletal disorder, leads to a gradual reduction in bone density and quantity. Primary osteoporosis, the major form including postmenopausal and age-related osteoporosis, is a worldwide public health issue.1 The methods used to treat osteoporosis have greatly expanded, enabling clinicians  \nto provide patients with individualized treatment plans.2-5 However, stronger therapy regimens may be essential for individuals with extremely low bone mineral density (BMD) and a new therapeutic objective is to develop osteoporosis medicines that raise BMD T-scores to > 2.5 within 5 years.  \nSuccessful spine surgery implant treatment relies on achieving optimal primary stabil","cbCaik9SK1OUJDun","https://ap.wps.com/l/cbCaik9SK1OUJDun","pdf",2882707,11,"English","# Objective\n# Methods\n# Results\n# Conclusion\n# Introduction\n## Background on osteoporosis and implant stability\n## Rationale for romosozumab and glucocorticoid effects","[{\"question\":\"What problem does the study address in osteoporotic bone implants?\",\"answer\":\"Osteoporotic bone has reduced mass and compromised microarchitecture, which limits primary stability and increases the risk of implant failure.\"},{\"question\":\"How was osteoporosis induced in the rabbit model?\",\"answer\":\"Osteoporosis was induced using either bilateral ovariectomy or weekly intramuscular glucocorticoid injections, with glucocorticoid injection selected based on bone mineral density results.\"},{\"question\":\"What outcomes were used to evaluate implant performance?\",\"answer\":\"Bone-to-implant contact and bone area fraction occupancy were assessed by histomorphometry, and mechanical pull-out strength was measured at 1-mm displacement.\"}]","Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone - A Rabbit Model Study | PDF",1790757166,28]