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This study evaluates associations between MEG3, PVT1, and H19 lncRNA polymorphisms and susceptibility to gastric cancer. In a high-risk Iranian region, 795 blood samples from 396 cases and 399 controls were genotyped and analyzed statistically and bioinformatically, identifying relevant genetic links and SNP–SNP interaction effects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/roles-of-the-lncrnas-meg3-pvt1-and-h19-tagsnps-in-gastric-cancer-susceptibility/331546/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/roles-of-the-lncrnas-meg3-pvt1-and-h19-tagsnps-in-gastric-cancer-susceptibility/331546.png","ImageObject",300,407,{"name":92,"@type":93},"Seraphina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which lncRNA tagSNPs showed significant associations with gastric cancer risk?","Question",{"text":112,"@type":113},"The H19 rs2107425 SNP was associated with gastric cancer risk under a recessive model, and the PVT1 rs13255292 variant significantly reduced gastric cancer risk under an overdominant model.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Were MEG3 and other H19 or PVT1 tagSNPs significantly associated with gastric cancer susceptibility?",{"text":117,"@type":113},"No significant associations were found for H19 rs2839698, MEG3 rs116907618, MEG3 rs11160608, or PVT1 rs7017386 and rs13254990 tagSNPs with gastric cancer susceptibility.",{"name":119,"@type":110,"acceptedAnswer":120},"Did the study find evidence of SNP–SNP interaction effects?",{"text":121,"@type":113},"Yes. The interaction between H19 rs2107425 TT and PVT1 rs7017386 TC increased gastric cancer risk, with a reported p value threshold.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331546,1790005054,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Abdi et al. BMC Cancer (2024) 24:1440 BMC Cancer  \n[https://doi.org/10.1186/s12885-024-13209-2](https://doi.org/10.1186/s12885-024-13209-2)  \nRESEARCH Open Access  \nRoles ofthe lncRNAs MEG3, PVT1 and H19 tagSNPs in gastric cancer susceptibility  \nEsmat Abdi 1, Saeid Latifi-Navid 1*, Vahid Kholghi-Oskooei2, Behdad Mostafaiy3, Farhad Pourfarzi4 and Abbas Yazdanbod4  \nAbstract  \nBackground Improper expression of long noncoding RNAs (lncRNAs) can cause various cancers. Single nucleotide polymorphisms (SNPs) affect the expression and function of several key lncRNAs. We assessed the associations of MEG3, PVT1, and H19 lncRNA polymorphisms with susceptibility to gastric cancer (GC) .  \nMethods In Ardabil (a high-risk area in North‒West Iran), 795 blood samples were collected from 396 cases and 399 controls. The control subjects were randomly selected from individuals receiving regular physical examinations in this hospital with no self-reported cancer history and were frequency-matched to the case group by sex and 5-year age intervals. All the samples were genotyped via the Infinium HTS platform, which was subsequently followed by rigorous data quality control, as well as statistical and bioinformatic analyses.  \nResults The H19 rs2107425 SNP was associated with GC risk in a recessive model of inheritance (TT vs. CC + CT:  \nOR = 1 . 87) . The PVT1 rs13255292 variant in the overdominant model significantly reduced GC risk (CTvs. CC + TT:  \nOR = 0 . 74) . There was no significant association between H19 rs2839698, MEG3 rs116907618, or rs11160608, or PVT1 rs7017386, rs13254990 tagSNPs and susceptibility to GC. The interaction between H19 rs2107425 TTand PVT1 rs7017386 TC increased GC risk (OR = 3 . 73; p bon \u003C 0. 05) . The MEG3, PVT1, and H19 variants were not associated with clinicopathologic characteristics.  \nConclusions We revealed significant associations ofthe H19 rs2107425 and PVT1 rs13255292 genetic variants with GC. Interestingly, the novel SNP‒SNP interaction of H19 and PVT1 tagSNPs had a greater effect than single SNP impacts did on GC risk, providing us with invaluable data to identify potential biological mechanisms involved in the development of GC.  \nKeywords MEG3, PVT1, H19, tagSNPs, SNP‒SNP interaction, Gastric cancer  \n*Correspondence:  \nSaeid Latifi-Navid  \n[s_latifi@uma.ac.ir](s_latifi@uma.ac.ir)  \n1Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil 56199-11367, Iran  \n2Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, Iran  \n3Department of Statistics, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil 5619911367, Iran  \n4Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil 5618953141, Iran  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nAbdi et al. BMC Cancer (2024) 24:1440  \nBackground  \nGastric cancer (GC) ranks among the most prevalent cancers globally [1]. In the year 2020, there were over 1,","cbCaikEADY4NZK6T","https://ap.wps.com/l/cbCaikEADY4NZK6T","pdf",1422722,"English","# Abstract\n# Background\n## Gastric cancer burden\n## Role of lncRNAs and MEG3 in carcinogenesis\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"Which lncRNA tagSNPs showed significant associations with gastric cancer risk?\",\"answer\":\"The H19 rs2107425 SNP was associated with gastric cancer risk under a recessive model, and the PVT1 rs13255292 variant significantly reduced gastric cancer risk under an overdominant model.\"},{\"question\":\"Were MEG3 and other H19 or PVT1 tagSNPs significantly associated with gastric cancer susceptibility?\",\"answer\":\"No significant associations were found for H19 rs2839698, MEG3 rs116907618, MEG3 rs11160608, or PVT1 rs7017386 and rs13254990 tagSNPs with gastric cancer susceptibility.\"},{\"question\":\"Did the study find evidence of SNP–SNP interaction effects?\",\"answer\":\"Yes. The interaction between H19 rs2107425 TT and PVT1 rs7017386 TC increased gastric cancer risk, with a reported p value threshold.\"}]","Roles of the lncRNAs MEG3, PVT1 and H19 tagSNPs in gastric cancer susceptibility | PDF",1789993854,25]