[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331799-105":59,"doc-detail-331799-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","roles-of-rictor-alterations-in-gastrointestinal-tumors-review","Roles of Rictor alterations in gastrointestinal tumors - Review","","Gastrointestinal tumors remain a major cause of cancer mortality, with colorectal, liver, stomach, esophageal, and pancreatic cancers contributing substantially to deaths. Rictor, a core component of mTOR complex 2 (mTORC2) within the PI3K/Akt pathway, shows a high alteration rate in these tumors and is frequently linked to chemotherapy resistance and worse clinical outcomes. The review critically examines Rictor mutation and biology, its roles across digestive-system cancers, and the current status and future prospects of targeted therapy aimed at Akt activation inhibition.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/roles-of-rictor-alterations-in-gastrointestinal-tumors-review/331799/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/roles-of-rictor-alterations-in-gastrointestinal-tumors-review/331799.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the significance of Rictor alterations in gastrointestinal tumors?","Question",{"text":113,"@type":114},"Rictor alterations occur at a high rate in gastrointestinal tumors and are often associated with resistance to chemotherapy and adverse clinical outcomes.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancers are specifically discussed regarding Rictor’s roles?",{"text":118,"@type":114},"The review focuses on colorectal, hepatobiliary, gastric, esophageal, pancreatic cancers, and cholangiocarcinoma.",{"name":120,"@type":111,"acceptedAnswer":121},"How does this review connect Rictor to targeted therapy?",{"text":122,"@type":114},"It evaluates targeted approaches that inhibit Akt activation, reflecting the role of the Rictor/mTORC2 axis in cancer biology and therapy resistance.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331799,1790322359,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","ONCOLOGY REPORTS 51: 37, 2024  \nRoles of Rictor alterations in gastrointestinal tumors (Review)  \nRUIZHEN CAO 1,2* , SHUILONG GUO 1* , LI MIN 1 and PENG LI 1  \n1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050; 2Department of Gastroenterology, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Ordos, Inner Mongolia 017000, P.R. China  \nReceived April 5, 2023; Accepted November 28, 2023  \nDOI: 10. 3892/or.2024.8696  \nAbstract. Gastrointestinal tumors account for five of the top 10 causes of mortality from all cancers (colorectal, liver, stomach, esophageal and pancreatic cancer) . Mammalian target of rapamycin (mTOR) signaling is commonly dysreg‑ ulated in various human cancers . As a core component of the mTOR complex 2 (mTORC2), Rictor is a key effector molecule of the PI3K/Akt pathway. A high alteration rate of Rictor has been observed in gastrointestinal tumors, and such Rictor alterations are often associated with resistance to chemotherapy and related adverse clinical outcomes . However, the exact roles of Rictor in gastrointestinal tumors remain elusive. The aim of the present study was to critically discuss the following: i) Mutation and biological characteristics of Rictor in tumors with a detailed overview of Rictor in cell proliferation, angiogenesis, apoptosis, autophagy and drug resistance; ii) the role of Rictor in tumors of the digestive system, particularly colorectal, hepatobiliary, gastric, esophageal and pancreatic cancer and cholangiocarcinoma; and iii) the current status and prospects of targeted therapy for Rictor by inhibiting Akt activation . Despite the growing realization of the importance of Rictor/mTORC2 in cancer, the underlying mechanistic details remain poorly understood; this needs to change in order for the development of efficient targeted therapies and re‑sensitization of therapy‑resistant cancers to be made possible.  \nCorrespondence to: Professor Peng Li, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, 95 Yong'an Road, Xicheng District, Beijing 100050, P.R. China  \nE‑mail: [lipeng@ccmu.edu.cn](lipeng@ccmu.edu.cn)  \n*Contributed equally  \nKey words: gastrointestinal tumors, mTOR, Rictor, PI3K, Akt  \nContents  \n1. Introduction  \n2. Overview of Rictor and the mTOR pathway  \n3. General biological effects of Rictor in cancer cells  \n4. Effects of Rictor in gastrointestinal cancers  \n5. Targeted therapy  \n6. Conclusion and future perspectives  \n1. Introduction  \nAccording to the most recent figures from the International Agency for Research on Cancer on incidence and mortality, there will be 28.4 million new cases of cancer worldwide in 2040, a 47% increase from 2020. Out of all cancer cases, gastrointestinal tumors account for five of the top 10 causes of mortality [colorectal cancer (CRC; 9.4%), liver cancer (8.3%), stomach cancer (7.7%), esophageal cancer (5.5%), and pancreatic cancer (4.7%)](1). Owing to the high metastasis and recurrence of these gastrointestinal tumors, the 5‑year overall survival rate for advanced tumors is poor (2,3) . Cancer treat‑ ment has undergone profound changes in recent years with the continuous development of the understanding of cancer biology at the molecular level. For instance, a large number of targeted drugs have been approved as a first‑line treatment for numerous tumors (4) . However, clinical studies revealed that these drugs are ineffective for patients with Rictor altera‑ tions (5) . These studies suggested that Rictor is involved in tumor resistance and may act as a therapeutic target.  \nGenomic instab","cbCaibl55MWgBrVb","https://ap.wps.com/l/cbCaibl55MWgBrVb","pdf",1328150,"English","# Contents\n## Introduction\n## Overview of Rictor and the mTOR pathway\n## General biological effects of Rictor in cancer cells\n## Effects of Rictor in gastrointestinal cancers\n## Targeted therapy\n## Conclusion and future perspectives","[{\"question\":\"What is the significance of Rictor alterations in gastrointestinal tumors?\",\"answer\":\"Rictor alterations occur at a high rate in gastrointestinal tumors and are often associated with resistance to chemotherapy and adverse clinical outcomes.\"},{\"question\":\"Which cancers are specifically discussed regarding Rictor’s roles?\",\"answer\":\"The review focuses on colorectal, hepatobiliary, gastric, esophageal, pancreatic cancers, and cholangiocarcinoma.\"},{\"question\":\"How does this review connect Rictor to targeted therapy?\",\"answer\":\"It evaluates targeted approaches that inhibit Akt activation, reflecting the role of the Rictor/mTORC2 axis in cancer biology and therapy resistance.\"}]","Roles of Rictor alterations in gastrointestinal tumors - Review | PDF",1789995216,28]