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Access  \nRNA 医学  \nDOI：10 .3724/zdxbyxb-2023-0056 ·专题报道 ·  \n外泌体来源非编码RNA在肿瘤微环境中的作用及临床应用价值  \n窦沁怡1，2，3，王嘉政1，2，3，杨滢硕1，2，3，卓 巍1，2，3  \n1.浙江大学医学院细胞生物学系，浙江杭州310058  \n2.浙江大学医学院附属第二医院 教育部消化系统肿瘤医药基础研究创新中心，浙江杭州310020  \n3.浙江大学癌症研究院，浙江杭州310058  \n［摘 要］ 肿瘤源性外泌体在肿瘤微环境中发挥重要作用。 外泌体来源非编码 RNA主要以三种途径在肿瘤微环境中传递，包括肿瘤细胞间相互交流、微环境细胞影响肿瘤细胞、肿瘤细胞影响微环境细胞。 通过这三种方式，外泌体来源非编码RNA参与肿瘤进展的调控，影响肿瘤血管的生成、肿瘤的侵袭性、耐药性、干性、肿瘤代谢重编程和免疫逃逸等过程，并呈现出促进或抑制肿瘤发展的双重作用。 外泌体具有膜性结构，其内容物能够抵抗胞外蛋白酶的降解，在体液中保持高度稳定，因此外泌体来源的非编码RNA有望成为多种癌症的诊断和预后指标。此外，在肿瘤治疗领域，可以利用外泌体递送非编码RNA进行靶向治疗，或者敲低或改造对肿瘤起促进作用的非编码RNA进行肿瘤治疗。 本文综述了外泌体非编码RNA在肿瘤微环境中的通信机制和功能，包括其作用途径、效应、标志物价值和靶向治疗潜力，并指出了有待深入研究的问题，以期促进外泌体来源非编码 RNA在肿瘤研究中的进展及在肿瘤诊疗中的应用。  \n［关键词］ 外泌体；非编码RNA；新生血管生成；转移；肿瘤微环境；综述［中图分类号］ R73 ［文献标志码］ A  \nRoles of exosome-derived non-coding RNA in tumor microenvironment and its clinical application  \nDOU Qinyi1,2,3, WANG Jiazheng1,2,3, YANG Yingshuo1,2,3, ZHUO Wei1,2,3（1. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China;  \n收稿日期（Received）:2023-02-12 接受日期（Accepted）: 2023-07-20 网络预发表日期（Online）: 2023-08-10 基金项目（Funding）:中央高校基本科研业务费专项资金（2022QZJH47）；国家自然科学基金（82173040）  \n第一作者（First author）:窦沁怡，大学生，主要从事胃肠肿瘤转移和微环境相关研究；[E](E-mail：3210102000@zju.edu.cn)[-](E-mail：3210102000@zju.edu.cn)[mail](E-mail：3210102000@zju.edu.cn)[：](E-mail：3210102000@zju.edu.cn)[3210102000@zju.edu.cn](E-mail：3210102000@zju.edu.cn)； [https](https：//orcid.org/0009-0000-7010-4508)[：](https：//orcid.org/0009-0000-7010-4508)[//orcid.org/0009](https：//orcid.org/0009-0000-7010-4508)[-](https：//orcid.org/0009-0000-7010-4508)[0000](https：//orcid.org/0009-0000-7010-4508)[-](https：//orcid.org/0009-0000-7010-4508)[7010](https：//orcid.org/0009-0000-7010-4508)[-](https：//orcid.org/0009-0000-7010-4508)[4508](https：//orcid.org/0009-0000-7010-4508) .王嘉政，大学生，主要从事胃肠肿瘤转移和微环境相关研究；E-mail：3210102750@zju. [edu.cn](edu.cn)；[https](https：//orcid.org/0009-0002-2534-6617)[：](https：//orcid.org/0009-0002-2534-6617)[//orcid.org/0009](https：//orcid.org/0009-0002-2534-6617)[-](https：//orcid.org/0009-0002-2534-6617)[0002](https：//orcid.org/0009-0002-2534-6617)[-](https：//orcid.org/0009-0002-2534-6617)[2534](https：//orcid.org/0009-0002-2534-6617)[-](https：//orcid.org/0009-0002-2534-6617)[6617](https：//orcid.org/0009-0002-2534-6617) .杨滢硕，大学生，主要从事中性粒细胞和胃癌转移相关研究；E-mail： [3210102795@zju.edu.cn](3210102795@zju.edu.cn)；[https](https：//orcid.org/0009-0000-1173-5107)[：](https：//orcid.org/0009-0000-1173-5107)[//orcid.org/0009](https：//orcid.org/0009-0000-1173-5107)[-](https：//orcid.org/0009-0000-1173-5107)[0000](https：//orcid.org/0009-0000-1173-5107)[-](https：//orcid.org/0009-0000-1173-5107)[1173](https：//orcid.org/0009-0000-1173-5107)[-](https：//orcid.org/0009-0000-1173-5107)[5107](https：//orcid.org/0009-0000-1173-5107)  \n通信作者（Corresponding author）:卓 巍，教授，博士生导师，主要从事肿瘤转移调控机制相关基础和转化研究工作；  \n[E](E-mail：wzhuo@zju.edu.cn)[-](E-mail：wzhuo@zju.edu.cn)[mail](E-mail：wzhuo@zju.edu.cn)[：](E-mail：wzhuo@zju.edu.cn)[wzhuo@zju.edu.cn](E-mail：wzhuo@zju.edu.cn)；[https](https：//orcid.org/0000-0002-8251-4210)[：](https：//orcid.org/0000-0002-8251-4210)[//orcid.org/0000](https：//orcid.org/0000-0002-8251-4210)[-](https：//orcid.org/0000-0002-8251-4210)[0002](https：//orcid.org/0000-0002-8251-4210)[-](https：//orcid.org/0000-0002-8251-4210)[8251](https：//orcid.org/0000-0002-8251-4210)[-](https：//orcid.org/0000-0002-8251-4210)[4210](https：//orcid.org/0000-0002-8251-4210)  \n2. The Second Affiliated Hospital, Zhejiang University School of Medicine, Center for Medical Research and Innovation in Digestive System Tumors ofthe Ministry of Education, Hangzhou 310020, China; 3. Zhejiang University Cancer Center, Hangzhou 310058, China）  \nDOU Qinyi, WANG Jiazheng and YANG Yingshuo contributed equally to the article. Corresponding author: ZHUO Wei, [E](E-mail: wzhuo@zju. edu. cn)[-](E-mail: wzhuo@zju. edu. cn)[mail: wzhuo@zju. edu. cn](E-mail: wzhuo@zju. edu. cn), [https://orcid. org/0000](https://orcid. org/0000-)[-](https://orcid. org/0000-)[ ](https://orcid. org/0000-)[0002](0002-8251-4210)[-](0002","cbCaiiIfZCSiWFwG","https://ap.wps.com/l/cbCaiiIfZCSiWFwG","pdf",1256534,"Chinese","en","# 摘要\n## 外泌体来源非编码RNA的传递途径\n## 对肿瘤进展相关过程的调控作用\n## 诊断与预后标志物潜力\n## 靶向治疗与治疗策略\n## 研究挑战与展望","[{\"question\":\"外泌体来源非编码RNA在肿瘤微环境中主要通过哪些途径传递？\",\"answer\":\"主要通过三条途径：肿瘤细胞间相互交流、微环境细胞影响肿瘤细胞，以及肿瘤细胞影响微环境细胞。\"},{\"question\":\"外泌体来源非编码RNA对肿瘤进展调控体现在哪些方面？\",\"answer\":\"可影响肿瘤血管生成、侵袭性、耐药性、干性、代谢重编程和免疫逃逸等过程，并呈现促进或抑制肿瘤发展的双重作用。\"},{\"question\":\"外泌体来源非编码RNA为何有望成为诊断和预后指标？\",\"answer\":\"外泌体具有膜性结构，内容物能抵抗胞外蛋白酶降解，在体液中保持高度稳定，因此具有作为诊断和预后指标的潜力。\"},{\"question\":\"如何利用外泌体递送非编码RNA进行肿瘤治疗？\",\"answer\":\"可利用外泌体递送非编码RNA实现靶向治疗，或敲低/改造对肿瘤起促进作用的非编码RNA以开展肿瘤治疗。\"}]","外泌体来源非编码RNA在肿瘤微环境中的作用及临床应用价值 | PDF",1790246166,25]