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A retrospective cohort enrolled 162 patients with invasive TNBC and collected sTIL density, Ki67, nuclear grade, lymphovascular invasion, AJCC stage, axillary node metastasis, and detailed ultrasound morphology and echo features. Posterior ultrasound features correlated with sTIL density, as did higher Ki67 and nuclear grades, with enrichment of high sTIL in posterior enhancement or absent posterior features.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-ultrasonographic-and-clinicopathological-characteristics-in-assessing-stromal-tumor-infiltrating-lymphocyte-density-in-triple-negative-breast-cancer/332787/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-ultrasonographic-and-clinicopathological-characteristics-in-assessing-stromal-tumor-infiltrating-lymphocyte-density-in-triple-negative-breast-cancer/332787.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the primary aim of this study?","Question",{"text":112,"@type":113},"To identify biomarkers that could complement evaluation of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative breast cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many TNBC patients were included, and what data were collected?",{"text":117,"@type":113},"A total of 162 patients were enrolled. The study collected sTIL density, Ki67, nuclear grades, lymphovascular invasion, AJCC stage, axillary node metastasis, and multiple ultrasound parameters.",{"name":119,"@type":110,"acceptedAnswer":120},"Which ultrasound and clinicopathological factors were associated with sTIL density?",{"text":121,"@type":113},"Posterior features of primary tumors, Ki67 levels, and nuclear grades were associated with sTIL density. High sTIL was more common with posterior enhancement or no posterior features than with acoustic shadows.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332787,1790174654,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Original Article  469  \nContent of this journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.  \nBalkan Med J 2024;41:469-75  \nRole of Ultrasonographic and Clinicopathological Characteristics in Assessing Stromal Tumor-Infiltrating Lymphocyte Density in Triple  \nNegative Breast Cancer  \n Lian Li,  Yingjia Li  \nDepartment of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, China  \nBackground: A high density of stromal tumor-infiltrating lymphocytes (sTILs) is positively correlated with the pathological complete response rate and favorable survival in patients with triple-negative breast cancer (TNBC) . Heterogeneity in stromal lymphocyte distribution and limited tumor sampling may affect the accuracy of sTIL quantification in biopsy samples from patients receiving neoadjuvant therapy. Thus, identifying additional biomarkers to complement sTIL evaluation is essential.  \nAims: To identify biomarkers that could be used to complement sTILs evaluation.  \nStudy Design: Retrospective cohort study.  \nMethods: A total of 162 patients with invasive TNBC were enrolled in the study. The following data were gathered: sTIL density, Ki67, nuclear grades of cancer cells, lymphovascular invasion status, the American Joint Committee on Cancer stage, axillary lymph node metastasis status, and ultrasonographic parameters of the tumor (size, shape, orientation, margin, internal echo pattern, posterior feature, and vascularity) . The relationship between sTIL density and ultrasonographic or clinicopathological characteristics was investigated using both continuous and categorical analyses.  \nResults: Posterior features of the primary tumors was associated with sTIL density (p = 0 .038) . Additionally, the Ki67 levels and nuclear grades were also associated with sTIL density (p \u003C 0.001 and p = 0.024, respectively) . When stratified according to a 20% cut-off of sTIL density, the posterior features of primary tumors, Ki67 levels, and nuclear grades significantly differed between the high and low sTIL density tumors. Tumors with high Ki67 levels were more likely to exhibit high sTIL density than low sTIL density [odds ratio (OR): 2 .75, p = 0 .021] . Furthermore, nuclear grade III tumors demonstrated significantly higher sTIL density than nuclear grade I-II tumors (OR: 2.49, p = 0.014) . Additionally, tumors with posterior enhancement or no posterior features were more likely to exhibit high sTIL density than tumors with acoustic shadows (OR: 2.91, p = 0.028; OR: 2.74, p = 0.022, respectively) .  \nConclusion: Low sTIL density is frequently observed in tumors exhibiting acoustic shadows on ultrasound. However, high sTIL density is more common in tumors with posterior enhancement or no posterior features. Furthermore, high Ki67 levels (> 40%) and high nuclear grades are positively correlated with high sTIL density. This study findings highlight the need for closer surveillance of these biomarkers to complement sTILevaluation in TNBC.  \nINTRODUCTION  \nThe immune system influences the prognosis of breast cancer.1,2 Stromal tumor-infiltrating lymphocytes (sTILs) are frequently observed in highly proliferative tumors. Furthermore, there is a positive correlation between sTILs and both the pathological complete response and survival rate in patients with triple-negative breast cancer (TNBC) .3-5 TNBC is the most immunogenic of the breast  \ncancer subtypes, displaying a prominent lymphocytic infiltration in the tumor stroma. Thus, the evaluation of sTILs may provide clinically significant prognostic data in TNBC.7-10  \nThe estimation of sTILs is based on the visual assessment of lymphocytes and plasma cells on routine hematoxylin and eosin (H&E)-stained sections. In patients receiving neoadjuvant therapy, the baseline sTIL density in primary tumors is determined in pre-  \nCorresponding author: Yingjia Li, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangz","cbCaibAk1OsGBnAc","https://ap.wps.com/l/cbCaibAk1OsGBnAc","pdf",1492956,"English","# Introduction\n# Materials and Methods\n## Patient population\n# Results\n# Conclusion","[{\"question\":\"What is the primary aim of this study?\",\"answer\":\"To identify biomarkers that could complement evaluation of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative breast cancer.\"},{\"question\":\"How many TNBC patients were included, and what data were collected?\",\"answer\":\"A total of 162 patients were enrolled. The study collected sTIL density, Ki67, nuclear grades, lymphovascular invasion, AJCC stage, axillary node metastasis, and multiple ultrasound parameters.\"},{\"question\":\"Which ultrasound and clinicopathological factors were associated with sTIL density?\",\"answer\":\"Posterior features of primary tumors, Ki67 levels, and nuclear grades were associated with sTIL density. High sTIL was more common with posterior enhancement or no posterior features than with acoustic shadows.\"}]","Role of Ultrasonographic and Clinicopathological Characteristics in Assessing Stromal Tumor-Infiltrating Lymphocyte Density in Triple-Negative Breast Cancer | PDF",1789999510,18]