[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379209-105":59,"doc-detail-379209-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","role-of-the-gut-microbiota-in-hematologic-cancer-mini-review","Role of the gut microbiota in hematologic cancer - Mini Review","","Hematologic neoplasms cause uncontrolled growth of hematopoietic and lymphoid cells while weakening immune efficacy, and emerging evidence links these conditions to disruption of gut microbiota balance. This mini review synthesizes studies describing gut microbiota features across hematologic diseases, including associations with opportunistic pathogens, shifts in dominant genera and reduced diversity in lymphoma. It also explains how factors such as delivery mode, diet, and environment may drive dysbiosis, impair immune responses, and influence cancer susceptibility and progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-the-gut-microbiota-in-hematologic-cancer-mini-review/379209/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-the-gut-microbiota-in-hematologic-cancer-mini-review/379209.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How is gut microbiota linked to hematologic cancer in this review?","Question",{"text":112,"@type":113},"The review describes how hematologic pathological conditions can disrupt gut microbiota balance, potentially promoting opportunistic pathogen proliferation and dysbiosis. Dysbiosis may then inhibit immune responses and increase cancer susceptibility.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which gut microbes or microbial patterns are discussed across different hematologic diseases?",{"text":117,"@type":113},"Myeloma is noted as often associated with Pseudomonas aeruginosa and Clostridium leptum. In leukemias, Streptococcus is highlighted as a common genus, while Lachnospiraceae and Ruminococcaceae are described as less prevalent. Lymphoma is associated with a moderate reduction in microbiota diversity.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms could explain how dysbiosis affects cancer progression?",{"text":121,"@type":113},"The review states that dysbiosis can alter cytokine signaling and affect immune system function, including inhibiting beneficial probiotic colonization and promoting harmful enteropathogens. It also discusses metabolite-related effects, including conflicting roles for butyrate depending on context.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379209,1790470187,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","TYPE Mini Review  \nPUBLISHED 25 August 2023  \nDOI 10.3389/fmicb.2023.1185787  \nOPEN ACCESS  \nEDITED BY  \nJinbo Xiong,  \nNingbo University, China  \nREVIEWED BY  \nDulcenombre Gomez-Garre, Hospital Clinico San Carlos, Spain Sona Ciernikova,  \nSlovak Academy of Sciences, Slovakia  \n*CORRESPONDENCE  \nAna Karina Zambrano  \n [anazambrano17@hotmail.com](anazambrano17@hotmail.com)  \n†These authors have contributed equally to this work  \nRECEIVED 14 March 2023  \nACCEPTED 11 August 2023  \nPUBLISHED 25 August 2023  \nCITATION  \nGuevara-Ramírez P, Cadena-Ullauri S, Paz-Cruz E, Tamayo-Trujillo R,  \nRuiz-Pozo VA and Zambrano AK (2023) Role of the gut microbiota in hematologic cancer. Front. Microbiol. 14:1185787.  \ndoi: 10.3389/fmicb.2023.1185787  \nCOPYRIGHT  \n© 2023 Guevara-Ramírez, Cadena-Ullauri, Paz-Cruz, Tamayo-Trujillo, Ruiz-Pozo and Zambrano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nRole of the gut microbiota in hematologic cancer  \nPatricia Guevara-Ramírez†, Santiago Cadena-Ullauri,  \nElius Paz-Cruz, Rafael Tamayo-Trujillo, Viviana A. Ruiz-Pozo and Ana Karina Zambrano *†  \nCentro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador  \nHematologic neoplasms represent 6. 5% of all cancers worldwide. They are characterized by the uncontrolled growth of hematopoietic and lymphoid cells and a decreased immune system efficacy. Pathological conditions in hematologic cancer could disrupt the balance of the gut microbiota, potentially promoting the proliferation of opportunistic pathogens. In this review, we highlight studies that analyzed and described the role of gut microbiota in different types of hematologic diseases. For instance, myeloma is often associated with Pseudomonas aeruginosa and Clostridium leptum, while in leukemias, Streptococcus is the most common genus, and Lachnospiraceae and Ruminococcaceae are less prevalent. Lymphoma exhibits a moderate reduction in microbiota diversity. Moreover, certain factors such as delivery mode, diet, and other environmental factors can alter the diversity of the microbiota, leading to dysbiosis. This dysbiosis may inhibit the immune response and increase susceptibility to cancer. A comprehensive analysis of microbiota-cancer interactions may be useful for disease management and provide valuable information on host-microbiota dynamics, as well as the possible use of microbiota as a distinguishable marker for cancer progression.  \nKEYWORDS  \nhematologic cancer, leukemia, lymphoma, microbiota, multiple myeloma  \nIntroduction  \nHematologic malignancies are characterized by the uncontrolled growth of hematopoietic and lymphoid cells, resulting in decreased immune system efficacy (Méndez-Ferrer et al., 2020) . Hematologic neoplasms account for 6.5% of all cancers worldwide (De Moraes Hungria et al., 2019; Kocarnik et al., 2022) . The World Health Organization (WHO) classifies hematologic malignancies based on morphology, immunophenotype, genetics, and clinical features (Khoury et al., 2022) . The most common subtypes include leukemia, Hodgkin’s lymphoma (HL), non-Hodgkin’s lymphoma (NHL), and multiple myeloma (MM) (Keykhaei et al., 2021) . Hematologic diseases have been associated with genetic factors and alterations ofthe immune system. However, several studies also suggest a potential correlation between hematologic cancers and alteration in the microbiota. For instance, research shown that the growth of gastric mucosa-associated lymphoid tissue (MALT) lymphoma tumors can be stimulated by signaling antigens released by the bacteriu","cbCaiiESuLQHluHu","https://ap.wps.com/l/cbCaiiESuLQHluHu","pdf",2224861,"English","# Introduction\n# Gut microbiota and metabolites\n## Metabolites such as SCFAs\n# Metagenomics and metabolomics in hematologic cancer\n# Dysbiosis, immune modulation, and cancer progression","[{\"question\":\"How is gut microbiota linked to hematologic cancer in this review?\",\"answer\":\"The review describes how hematologic pathological conditions can disrupt gut microbiota balance, potentially promoting opportunistic pathogen proliferation and dysbiosis. Dysbiosis may then inhibit immune responses and increase cancer susceptibility.\"},{\"question\":\"Which gut microbes or microbial patterns are discussed across different hematologic diseases?\",\"answer\":\"Myeloma is noted as often associated with Pseudomonas aeruginosa and Clostridium leptum. In leukemias, Streptococcus is highlighted as a common genus, while Lachnospiraceae and Ruminococcaceae are described as less prevalent. Lymphoma is associated with a moderate reduction in microbiota diversity.\"},{\"question\":\"What mechanisms could explain how dysbiosis affects cancer progression?\",\"answer\":\"The review states that dysbiosis can alter cytokine signaling and affect immune system function, including inhibiting beneficial probiotic colonization and promoting harmful enteropathogens. It also discusses metabolite-related effects, including conflicting roles for butyrate depending on context.\"}]","Role of the gut microbiota in hematologic cancer - Mini Review | PDF",1790234621,25]