[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339563-105":59,"doc-detail-339563-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","role-of-syt11-in-human-pan-cancer-using-comprehensive-approaches","Role of SYT11 in human pan-cancer using comprehensive approaches","","Background Synaptotagmin 11 (SYT11) is essential for neuronal vesicular trafficking and exocytosis, yet independent prognostic evidence across cancers has been limited. Using multiple public databases, the study examines aberrant SYT11 expression across tumor types and evaluates links with prognosis, methylation patterns, immune infiltration, pathway enrichment, and protein–protein interactions to identify shared molecular processes. TCGA and GTEx data show broad SYT11 expression and survival associations in seven cancers, with regulation by specific miRNAs, supported by in vitro validation and immune-related correlations. ",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-syt11-in-human-pan-cancer-using-comprehensive-approaches/339563/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-syt11-in-human-pan-cancer-using-comprehensive-approaches/339563.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is SYT11 and why is it important in cancers?","Question",{"text":112,"@type":113},"SYT11 is a synaptotagmin family protein involved in neuronal vesicular trafficking and exocytosis. The study highlights that, despite its known roles, independent prognostic studies across diverse cancers were lacking.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the researchers analyze SYT11 across tumor types?",{"text":117,"@type":113},"They used several public databases to assess abnormal SYT11 expression and its association with prognosis, promoter methylation, immune infiltration, enrichment results, and protein–protein interactions, aiming to identify common pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"What main findings connect SYT11 expression with clinical outcomes?",{"text":121,"@type":113},"SYT11 was broadly expressed in tumor and corresponding normal tissues. Survival analysis linked SYT11 expression to prognosis in seven cancer types, and SYT11 mRNA levels were not explained by promoter methylation but were associated with certain miRNAs and immune infiltration, supported by in vitro negative correlation with miR-19a-3p in multiple cancer cell lines.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},339563,1790278818,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","Noh etal. European Journal  \nEuropean Journal of Medical Research (2024) 29:338  \n[https://doi.org/10.1186/s40001-024-01931-3](https://doi.org/10.1186/s40001-024-01931-3 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-024-01931-3 of Medical Research)  \n RESEARCH Open Access  \nRole of SYT11 in human pan-cancer using comprehensive approaches  \nKyunghee Noh 1,2, Hyunji Choi3, Eun‑Hye Jo3, Wonbeak Yoo3* and Kyung Chan Park3,4*  \nAbstract  \nBackground Synaptotagmin 11 (SYT11) plays a pivotal role in neuronal vesicular trafficking and exocytosis. However, no independent prognostic studies have focused on various cancers. In this study, we aimed to summarize the clinical significance and molecular landscape of SYT11 in various tumor types.  \nMethods Using several available public databases, we investigated abnormal SYT11 expression in different tumor types and its potential clinical association with prognosis, methylation profiling, immune infiltration, gene enrichment analysis, and protein–protein interaction analysis, and identified common pathways.  \nResults TCGA and Genotype‑Tissue Expression (GTEx) showed that SYT11 was widely expressed across tumor and corresponding normal tissues. Survival analysis showed that SYT11 expression correlated with the prognosis of seven cancer types. Additionally, SYT11 mRNA expression was not affected by promoter methylation, but regu‑ lated by certain miRNAs and associated with cancer patient prognosis. In vitro experiments further verified a negative correlation between the expression of SYT11 and miR‑19a‑3p in human colorectal, lung, and renal cancer cell lines. Moreover, aberrant SYT11 expression was significantly associated with immune infiltration. Pathway enrichment analysis revealed that the biological and molecular processes of SYT11 were related to clathrin‑mediated endocytosis, Rho GTPase signaling, and cell motility‑related functions.  \nConclusions Our results provide a clear understanding of the role of SYT11 in various cancer types and suggest that SYT11 may be of prognostic and clinical significance.  \nKeywords SYT11, Prognosis, Genetic alteration, Immune cell infiltration, Enrichment analysis  \n*Correspondence: Wonbeak Yoo [wyoo@kribb. re.kr](wyoo@kribb. re.kr)[ ](wyoo@kribb. re.kr)Kyung Chan Park  \n[kpark@kribb. re.kr](kpark@kribb. re.kr); [wyoo@kribb. re.kr](wyoo@kribb. re.kr)  \n1 Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea  \n2 Department of Nanobiotechnology, University of Science and Technology (UST), Daejeon 34141, Republic of Korea  \n3 Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea  \n4 Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34113, Republic of Korea  \nIntroduction  \nCancer is one of the leading causes of death worldwide [1] and considered an important factor affecting healthy human life and decreasing life expectancy. Therefore, a novel strategy to overcome cancer is one of the most urgent public health challenges. In the past few years, the advent of standard chemotherapy and supportive therapy has provided new ideas for cancer treatment [2–4]; however, the prognosis of patients with advanced cancer remains poor. Therefore, there is an urgent need to identify novel therapeutic targets with enhanced prognostic potential.  \nSynaptotagmin-11 (SYT11), a member of the synaptotagmin (SYT) family, is almost exclusively expressed in the brain tissue [5]. Recent studies have reported that  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons lice","cbCaifYiOU6Pu7oA","https://ap.wps.com/l/cbCaifYiOU6Pu7oA","pdf",8757958,15,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusions\n# Introduction","[{\"question\":\"What is SYT11 and why is it important in cancers?\",\"answer\":\"SYT11 is a synaptotagmin family protein involved in neuronal vesicular trafficking and exocytosis. The study highlights that, despite its known roles, independent prognostic studies across diverse cancers were lacking.\"},{\"question\":\"How did the researchers analyze SYT11 across tumor types?\",\"answer\":\"They used several public databases to assess abnormal SYT11 expression and its association with prognosis, promoter methylation, immune infiltration, enrichment results, and protein–protein interactions, aiming to identify common pathways.\"},{\"question\":\"What main findings connect SYT11 expression with clinical outcomes?\",\"answer\":\"SYT11 was broadly expressed in tumor and corresponding normal tissues. Survival analysis linked SYT11 expression to prognosis in seven cancer types, and SYT11 mRNA levels were not explained by promoter methylation but were associated with certain miRNAs and immune infiltration, supported by in vitro negative correlation with miR-19a-3p in multiple cancer cell lines.\"}]","Role of SYT11 in human pan-cancer using comprehensive approaches | PDF",1790031017,38]