[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-326693-105":59,"doc-detail-326693-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","role-of-slc7a11xct-in-ovarian-cancer-review","Role of SLC7A11/xCT in Ovarian Cancer - Review","","Ovarian cancer is among the most dangerous gynecologic malignancies worldwide, with high mortality driven by late-stage diagnosis and frequent recurrence. Recurrence is strongly linked to chemotherapy resistance, which blunts treatment efficacy and worsens patient outcomes. Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) functions as the X system anionic L-cystine/L-glutamate antiporter on the cell surface. SLC7A11 is often upregulated in cancers where it suppresses ferroptosis and promotes proliferation, invasion, and chemoresistance, and its increased expression is reported in ovarian cancer tissues. This review summarizes current literature on SLC7A11 in ovarian cancer to support insights into its modulation and assess its potential as a therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-slc7a11xct-in-ovarian-cancer-review/326693/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-slc7a11xct-in-ovarian-cancer-review/326693.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is chemotherapy resistance critical in ovarian cancer outcomes?","Question",{"text":112,"@type":113},"Chemoresistance weakens therapeutic effects and contributes to relapse, especially after platinum/taxane treatment in advanced disease.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is SLC7A11 (xCT) and what role does it play in cancer cells?",{"text":117,"@type":113},"SLC7A11 is the functional subunit of the X system, an anionic L-cystine/L-glutamate antiporter on the cell surface. Its upregulation can inhibit ferroptosis and support cancer cell proliferation, invasion, and chemoresistance.",{"name":119,"@type":110,"acceptedAnswer":120},"How does this review use existing evidence to evaluate SLC7A11 in ovarian cancer?",{"text":121,"@type":113},"It provides an overview of current literature on the role of SLC7A11 in ovarian cancer, with the goal of generating insights into SLC7A11 modulation and assessing its potential as a therapeutic target.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326693,1790845245,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","Review  \nRole of SLC7A11/xCT in Ovarian Cancer  \nSonia Fantone 1, Federica Piani 2, Fabiola Olivieri 1,3, Maria Rita Rippo 3, Angelo Sirico 4, Nicoletta Di Simone 5,6, Daniela Marzioni 7 and Giovanni Tossetta 7, *  \nCitation: Fantone, S.; Piani, F.;  \nOlivieri, F.; Rippo, M.R.; Sirico, A.; Di Simone, N.; Marzioni, D.; Tossetta, G. Role of SLC7A11/xCT in Ovarian Cancer. Int. J. Mol. Sci. 2024, 25, 587 . [https://doi.org/10.3390/ijms25010587](https://doi.org/10.3390/ijms25010587)  \nAcademic Editor: Vladimir Isachenko  \n1 Scientific Direction, IRCCS INRCA, 60124 Ancona, Italy; s.fantone@inrca.it (S.F.);  \n[f.olivieri@staff.univpm.it](f.olivieri@staff.univpm.it) (F.O.)  \n2 Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy; federica.piani@unibo.it  \n3 Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche,  \n60126 Ancona, Italy; [m.r.rippo@staff.univpm.it](m.r.rippo@staff.univpm.it)  \n4 Obstetrics and Gynecology Unit, Sant’Anna e San Sebastiano Hospital, 81100 Caserta, Italy; [siricoangelo@gmail.com](siricoangelo@gmail.com)  \n5 Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy; [nicoletta.disimone@hunimed.eu](nicoletta.disimone@hunimed.eu)  \n6 IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy  \n7 Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy; [d.marzioni@staff.univpm.it](d.marzioni@staff.univpm.it)  \n* Correspondence: [g.tossetta@univpm.it](g.tossetta@univpm.it)  \nAbstract: Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology. Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) is the functional subunit of the X system, an anionic L-cystine/L-glutamate antiporter expressed on the cell surface. SLC7A11 expression is significantly upregulated in several types of cancers in which it can inhibit ferroptosis and favor cancer cell proliferation, invasion and chemoresistance. SLC7A11 expression is also increased in ovarian cancer tissues, suggesting a possible role of this protein as a therapeutic target. In this review, we provide an overview of the current literature regarding the role of SLC7A11 in ovarian cancer to provide new insights on SLC7A11 modulation and evaluate the potential role of SLC7A11 as a therapeutic target.  \nKeywords: SLC7A11; ovarian cancer; chemoresistance; nuclear factor erythroid 2-related factor 2 (NRF2); oxidative stress; reactive oxygen species (ROS); non-coding RNAs; p53; compounds; xCT  \n1. Introduction  \nReceived: 18 November 2023  \nRevised: 21 December 2023  \nAccepted: 28 December 2023  \nPublished: 2 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nGynecologic cancers are common among older women. Almost 50% of ovarian cancers occur in women aged >65 years and are the major cause of death since most diagnoses are often made when the disease is already at an advanced stage [1] . Although the most common risk factors for developing ovarian cancer are genetic and epigenetic factors, environmental factors and lifestyle also have important roles in its etiopathogenesis [2,3] .  \nIn fact, the depletion of ovarian function during aging not only leads to a reduced reproductive capacity but also increases the risk of ovarian cancer. This cancer can therefore be consid","cbCaibhJtW9iXzo7","https://ap.wps.com/l/cbCaibhJtW9iXzo7","pdf",2031413,17,"English","# Introduction\n## SLC7A11 (xCT) and cancer relevance\n## Aging, epidemiology, and ovarian cancer subtypes\n## Current treatment and chemoresistance\n## Mechanisms of platinum and taxane action and resistance","[{\"question\":\"Why is chemotherapy resistance critical in ovarian cancer outcomes?\",\"answer\":\"Chemoresistance weakens therapeutic effects and contributes to relapse, especially after platinum/taxane treatment in advanced disease.\"},{\"question\":\"What is SLC7A11 (xCT) and what role does it play in cancer cells?\",\"answer\":\"SLC7A11 is the functional subunit of the X system, an anionic L-cystine/L-glutamate antiporter on the cell surface. Its upregulation can inhibit ferroptosis and support cancer cell proliferation, invasion, and chemoresistance.\"},{\"question\":\"How does this review use existing evidence to evaluate SLC7A11 in ovarian cancer?\",\"answer\":\"It provides an overview of current literature on the role of SLC7A11 in ovarian cancer, with the goal of generating insights into SLC7A11 modulation and assessing its potential as a therapeutic target.\"}]","Role of SLC7A11/xCT in Ovarian Cancer - Review | PDF",1789975102,43]