[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331367-105":59,"doc-detail-331367-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","role-of-pyroptosis-in-endometrial-cancer-and-its-therapeutic-regulation","Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation","","Pyroptosis is an inflammatory programmed cell death triggered by inflammasomes that release pro-inflammatory mediators including IL-18 and IL-1β. Evidence links inflammasomes and pyroptosis to diverse pathological conditions, and dysregulation of these pathways contributes to endometriosis and gynecological malignancies. In endometrial cancer, NLRP3 and caspase-1-dependent pyroptosis support disease pathogenesis, suggesting pyroptosis-regulated GSDMD as an independent prognostic biomarker and a basis for new anti-cancer strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-pyroptosis-in-endometrial-cancer-and-its-therapeutic-regulation/331367/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-pyroptosis-in-endometrial-cancer-and-its-therapeutic-regulation/331367.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is pyroptosis and how is it activated?","Question",{"text":112,"@type":113},"Pyroptosis is inflammatory programmed cell death induced by inflammasomes. These inflammasomes release pro-inflammatory mediators such as IL-18 and IL-1β.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do inflammasomes and pyroptosis relate to endometrial cancer?",{"text":117,"@type":113},"Dysregulation of inflammasomes and pyroptosis-dependent signaling pathways is described as contributing to the progression of endometrial cancer. Specifically, NLRP3 and caspase-1-dependent pyroptosis play contributory roles in its pathogenesis and development.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is GSDMD highlighted in this review?",{"text":121,"@type":113},"The review states that pyroptosis-regulated GSDMD may serve as an independent prognostic biomarker for detecting endometrial cancer. It also connects pyroptosis-dependent signaling mechanisms to advancing the disease’s understanding and treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331367,1790165125,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Journal of Inflammation Research Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nRole of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation  \nAbdullah Al Mamun 1 , 2 , Peiwu Geng 1 , Shuanghu Wang 1 , Chuxiao Shao 1  \n1Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang, 323000, People’s Republic of China; 2Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China  \nCorrespondence: Chuxiao Shao; Shuanghu Wang, Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, the Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang, 323000, People’s Republic of China, Email [scx1818@126.com](scx1818@126.com); [wangshuanghu@lsu.edu.cn](wangshuanghu@lsu.edu.cn)  \n\n| Abstract: Pyroptosis is an inflammatory cell death induced by inflammasomes that release several pro-inflammatory mediators such as interleukin-18 (IL-18) and interleukin-1β (IL-1β) . Pyroptosis, a type of programmed cell death, has recently received increased interest both as a therapeutic and immunological mechanism. Numerous studies have provided substantial evidence supporting the involvement of inflammasomes and pyroptosis in a variety of pathological conditions including cancers, nerve damage, inflammatory diseases and metabolic conditions. Researchers have demonstrated that dysregulation of pyroptosis and inflammasomes contribute to the progression of endometriosis and gynecological malignancies. Current research also indicates that inflammasome and pyroptosisdependent signaling pathways may further induce the progression of endometrial cancer (EC) . More specifically, dysregulation of NLR family pyrin domain 3 (NLRP3) and caspase-1-dependent pyroptosis play a contributory role in the pathogenesis and development of EC. Therefore, pyroptosis-regulated protein gasdermin D (GSDMD) may be an independent prognostic biomarker for the detection of EC. This review presents the molecular mechanisms of pyroptosis-dependent signaling pathways and their contributory role and function in advancing EC. Moreover, this review offers new insights into potential future applications and innovative approaches in utilizing pyroptosis to develop effective anti-cancer therapies.\u003Cbr>Keywords: endometrial cancer, pyroptosis, NLRP3, caspase-1, GSDMD, IL-1β, IL-18 |\n| --- |\n| Introduction\u003Cbr>Endometrial cancer (EC) is the predominant form of gynecologic malignancy worldwide. The incidence of EC is approximately 142,000 women per year with an estimated 42,000 women dying from this disease.1 There is currently a predominant role for surgical interventions in the management of patients without reproductive needs.2 However, patients with elevated risk factors may require additional treatment techniques such as radiation and chemotherapy. These therapeutic approaches promote ROS-mediated stress and induce apoptosis in cancer cells. Cancer-related deficiencies in apoptosis initiation may occur, but there is also the possibility of an “oncogene addiction” phenomenon that can result in treatment ineffectiveness.3 Cancer cells are exquisitely dependent upon a single oncogenic lesion through many genetic and epigenetic changes during the development of their neoplastic characteristics. It was found in a laboratory setting that tumor cells could depend on tumor cells when an oncogene was suppressed or tumor suppressor expression was restored, which led to the initial suggestion that the developemnt of tumor cells could depend on tumor cells. These first discoveries suggested that therapeutic drugs aimed at the repair or re","cbCainZpojdSEcpe","https://ap.wps.com/l/cbCainZpojdSEcpe","pdf",5442446,"English","# Abstract\n# Introduction","[{\"question\":\"What is pyroptosis and how is it activated?\",\"answer\":\"Pyroptosis is inflammatory programmed cell death induced by inflammasomes. These inflammasomes release pro-inflammatory mediators such as IL-18 and IL-1β.\"},{\"question\":\"How do inflammasomes and pyroptosis relate to endometrial cancer?\",\"answer\":\"Dysregulation of inflammasomes and pyroptosis-dependent signaling pathways is described as contributing to the progression of endometrial cancer. Specifically, NLRP3 and caspase-1-dependent pyroptosis play contributory roles in its pathogenesis and development.\"},{\"question\":\"Why is GSDMD highlighted in this review?\",\"answer\":\"The review states that pyroptosis-regulated GSDMD may serve as an independent prognostic biomarker for detecting endometrial cancer. It also connects pyroptosis-dependent signaling mechanisms to advancing the disease’s understanding and treatment.\"}]","Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation | PDF",1789992952]