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Materials and Methods: A total of 100 histopathology-confirmed OSMF patients were recruited; purified DNA from tissue blocks was quantified by spectrophotometry and HPV prevalence was evaluated. Patients were randomized into HPV positive and HPV negative cohorts, received physiotherapy, and outcomes were compared using SPSS-based statistical analysis. Results: HPV was detected in 80% of patients, with significant improvements in mouth opening after physiotherapy in both groups. Conclusion: Physiotherapy outcome in OSMF is independent of HPV status.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-physiotherapy-in-hpv-proven-cases-of-oral-submucous-fibrosis/380376/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-physiotherapy-in-hpv-proven-cases-of-oral-submucous-fibrosis/380376.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How were participants selected for the study?","Question",{"text":113,"@type":114},"The study recruited 100 patients with oral submucous fibrosis, and only histopathologically confirmed cases were enrolled.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was HPV status determined?",{"text":118,"@type":114},"Purified DNA from paraffin-embedded tissue blocks was quantified by spectrophotometry, and HPV prevalence was evaluated to classify patients into HPV positive and HPV negative cohorts.",{"name":120,"@type":111,"acceptedAnswer":121},"What exercises were included in the physiotherapy?",{"text":122,"@type":114},"The physiotherapy program included tongue blade exercise, china ball exercise, blowing the mouth, and tongue protrusion exercises.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},380376,1790784927,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":39},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Review Article  \nRole of Physiotherapy in HPV Proven Cases of Oral Submucous Fibrosis  \nFarkhanda Syed1, Hafiz Ul Islam Wani2, Satyendra K. Jha3, Kalyan Banerjee4, Sudhanshu Singh4, Anjali P. Kumar5  \n1Department of Microbiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India, 2Department of Physiotherapy, Elaj Medical Centre LLC, Ajman, UAE, 3Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India, 4Department Oral and Maxillofacial Surgery, Awadh Dental College and Hospital, Jamshedpur, Jharkhand, India, 5Department of Oral and Maxillofacial Surgery, RKDF Dental College, Bhopal, Madhya Pradesh, India  \nSubmitted: 17‑Mar‑2023  \nRevised: 19‑Mar‑2023  \nAccepted: 21‑Mar‑2023  \nPublished: 11‑Jul‑2023  \nAbstract  \nBackground: To assess the role of physiotherapy in human papillomavirus (HPV) proven cases of oral submucous fibrosis (OSMF) . Materials and Methods: Overall, 100 patients got recruited. Only histopathologic confirmed cases of OSMF were enrolled. Purified DNA of tissue blocks was quantified by spectrophotometry. Prevalence of HPV was evaluated. The participants got randomized into 2 cohorts: HPV positive cases and HPV negative cases. Physiotherapy was done and outcome was done and outcome was assessed and compared. Assessment of results was done by SPSS software followed by statistical evaluation. Results: HPV was seen in 80% of the patients. Mean mouth opening pretreatment and postphysiotherapy among patients with HPV positive status was 26.31 mm and 30.12 mm, respectively. Mean mouth opening pretreatment and postphysiotherapy among patients with HPV negative status was 25.11 mm and 29.74 mm, respectively. Nonsignificant results were obtained while comparing the outcome of physiotherapy among HPV positive and negative groups. Conclusion: Outcome of physiotherapy among OSMF patients is independent of HPV status.  \nKeywords: HPV, oral submucous fibrosis, physiotherapy   \nIntroduction  \nThise  \nsixth most prevalent form of cancer, oral cancer, a serious issue for global health. [1] Pre‑existing  \noral lesions known as potentially malignant diseases of the oral mucosa frequently precede more than 90% of such malignancies that reflect squamous cell carcinoma in the oral cavity. The etiopathogenesis of oral Squamous cell carcinoma (SCC) is multiphasic and complex. It is the most common kind of neoplasm in India and other Southeast Asian countries, responsible for up to 50% of all cancerous tumors. [2,3] A disease known as oral submucous fibrosis (OSMF) causes the oral mucosa to become stiff and also is characterized by epithelial immune cell infiltration, followed by a fibro‑elastic alteration in the lamina propria and submucosa. [4,5] Expression of the viral E6 and E7 oncoproteins that result in cell cycle dysregulation by  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website: [https://journals.lww.com/jpbs](https://journals.lww.com/jpbs) |\n|  | DOI: 10.4103/jpbs.jpbs_273_23 |\n\ninactivating p53 and pRb, accordingly, is what drives HPV‑associated carcinogenesis. By ubiquitin‑mediated proteolysis, the E6 protein causes p53 to be degraded, significantly decreasing p53 function. [6‑8] The typical role of p53 is to initiate apoptosis or to hold cells in the G1 phase, which enables host DNA to be repaired. The presence of HPV seems to have a significant impact on patient characteristics and clinical implications. [9] To determine the incidence of HPV in OSMF and the impact of physiotherapy on the intensity of the condition, this research was carried out.  \n\n| Address for correspondence: Dr. Farkhanda Syed, Department of Microbiology, Dasmesh Institute of Research and Dental Sciences, Faridkot ‑ 151203, Punjab, India.\u003Cbr>E‑mail: [nailasyed@gmail.com](nailasyed@gmail.com) |\n| --- |\n| This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike ","cbCaidTvnP0XluXs","https://ap.wps.com/l/cbCaidTvnP0XluXs","pdf",456441,"English","# Abstract\n# Introduction\n# Materials and Methods\n# Results","[{\"question\":\"How were participants selected for the study?\",\"answer\":\"The study recruited 100 patients with oral submucous fibrosis, and only histopathologically confirmed cases were enrolled.\"},{\"question\":\"How was HPV status determined?\",\"answer\":\"Purified DNA from paraffin-embedded tissue blocks was quantified by spectrophotometry, and HPV prevalence was evaluated to classify patients into HPV positive and HPV negative cohorts.\"},{\"question\":\"What exercises were included in the physiotherapy?\",\"answer\":\"The physiotherapy program included tongue blade exercise, china ball exercise, blowing the mouth, and tongue protrusion exercises.\"}]","Role of Physiotherapy in HPV Proven Cases of Oral Submucous Fibrosis | PDF",1790239950]