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Results indicate NF2 mutations occur in over 11 cancer types with evidence of Hippo signaling involvement in 8 of 11 cancers, while specific mechanistic details remain unclear and require further study.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/role-of-nf2-mutation-in-the-development-of-eleven-different-cancers/332940/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/role-of-nf2-mutation-in-the-development-of-eleven-different-cancers/332940.png","ImageObject",300,407,{"name":42,"@type":43},"Theodora","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of this review?","Question",{"text":63,"@type":64},"To update understanding of the NF2 gene and clarify its role in the pathogenesis of various cancers, including the extent of association and affected biological pathways.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the literature gathered for the review?",{"text":68,"@type":64},"A comprehensive search of five online databases identified 43 studies focused on the effect of sporadic NF2 mutations across multiple cancer types.",{"name":70,"@type":61,"acceptedAnswer":71},"What key biological pathway is highlighted in NF2-mutated cancers?",{"text":72,"@type":64},"The Hippo signaling pathway, with evidence of Hippo signaling cascade involvement in 8 of the 11 cancers covered in the review.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332940,1791122072,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":109,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","Review  \nRole of NF2 Mutation in the Development of Eleven Different Cancers  \nShervin Hosseingholi Nouri 1, Vijay Nitturi 1, Elizabeth Ledbetter 1, Collin W. English 1, Sean Lau 1, Tiemo J. Klisch 1,2 and Akash J. Patel 1,2,3, *  \nAcademic Editor: Amancio Carnero  \nReceived: 2 December 2024  \nRevised: 18 December 2024  \nAccepted: 27 December 2024  \nPublished: 29 December 2024  \nCitation: Nouri, S.H.; Nitturi, V.; Ledbetter, E.; English, C.W.; Lau, S.; Klisch, T.J.; Patel, A.J. Role of NF2 Mutation in the Development of Eleven Different Cancers. Cancers 2025, 17, 64. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers17010064  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; [shervin.hosseingholinouri@bcm.edu](shervin.hosseingholinouri@bcm.edu) (S.H.N.); [vijay.nitturi@bcm.edu](vijay.nitturi@bcm.edu) (V.N.); [elizabeth.ledbetter@bcm.edu](elizabeth.ledbetter@bcm.edu) (E.L.); [collin.english@bcm.edu](collin.english@bcm.edu) (C.W.E.); [sean.lau@bcm.edu](sean.lau@bcm.edu) (S.L.); [tiemo.klisch@bcm.edu](tiemo.klisch@bcm.edu) (T.J.K.)  \n2 Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA  \n3 Department of Otolaryngology–Head & Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA  \n* Correspondence: [akash.patel@bcm.edu](akash.patel@bcm.edu)  \nSimple Summary: In this study, we sought to understand the role of NF2 gene mutation in the carcinogenesis of sporadic cancers. NF2 gene mutations are noted in several central nervous system tumors, solid-organ tumors, and skin cancers. We conducted a literature review on eleven different cancers with NF2 gene mutation involvement, summarizing the extent of association and specific biological pathways thought to be affected by NF2 mutations. We synthesized studies across several oncologic fields to consolidate what we know about NF2 gene mutations in cancer development. The Hippo signaling pathway is a biological pathway that is involved in eight of the eleven NF2-mutated cancers studied in this review. Although NF2 mutation has a known interaction with the Hippo signaling pathway, the specific details of this interface remain a topic for further studies.  \nAbstract: Background/Objectives: With the rise in prevalence of diagnostic genetic techniques like RNA sequencing and whole exome sequencing (WES), as well as biological treatment regiments for cancer therapy, several genes have been implicated in carcinogenesis. This review aims to update our understanding of the Neurofibromatosis 2 (NF2) gene and its role in the pathogenesis of various cancers. Methods: A comprehensive search of five online databases yielded 43 studies that highlighted the effect of sporadic NF2 mutations on several cancers, including sporadic meningioma, ependymoma, schwannoma, mesothelioma, breast cancer, hepatocellular carcinoma, prostate cancer, glioblastoma, thyroid cancer, and melanoma. Of note were key biological pathways implicated in cancer formation resulting from sporadic NF2 mutations. Results: NF2 gene mutations are implicated in over 11 different cancers, including several CNS tumors, soli-organ tumors, and skin cancer. NF2 acts as a driver mutation in some cancers, as a non-driver mutation in some cancers, and has simple associated mutations with other cancers. In terms of biological pathway involvement, 8 of the 11 cancers with NF2 mutations show evidence of Hippo signaling cascade involvement. Conclusions: Several cancers characterized by mutations in the NF2 gene have associations with the Hippo signaling pathway. However, future studies re","cbCaijzoEPAx88VG","https://ap.wps.com/l/cbCaijzoEPAx88VG","pdf",1027899,16,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction\n## Cancer background and genomic approaches\n## NF2 mutation and therapeutic context","[{\"question\":\"What is the main purpose of this review?\",\"answer\":\"To update understanding of the NF2 gene and clarify its role in the pathogenesis of various cancers, including the extent of association and affected biological pathways.\"},{\"question\":\"How was the literature gathered for the review?\",\"answer\":\"A comprehensive search of five online databases identified 43 studies focused on the effect of sporadic NF2 mutations across multiple cancer types.\"},{\"question\":\"What key biological pathway is highlighted in NF2-mutated cancers?\",\"answer\":\"The Hippo signaling pathway, with evidence of Hippo signaling cascade involvement in 8 of the 11 cancers covered in the review.\"}]","Role of NF2 Mutation in the Development of Eleven Different Cancers | PDF",1790000073]