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Molecular imaging converts otherwise visually unidentifiable pathophysiological information from anatomical imaging into high-dimensional quantitative image features. By enabling in vivo molecular tissue profiling, it supports phenotyping receptor and target expression for biological therapy, and enables expression-tailored personalized treatment and monitoring. This review first summarizes technical aspects and then evaluates recent diagnostic and prognostic research plus future clinical methods for GI tract malignancies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-molecular-imaging-in-prognosis-diagnosis-and-treatment-of-gastrointestinal-cancers-an-update-on-new-therapeutic-methods/331119/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-molecular-imaging-in-prognosis-diagnosis-and-treatment-of-gastrointestinal-cancers-an-update-on-new-therapeutic-methods/331119.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is molecular imaging important for gastrointestinal cancers compared with conventional imaging?","Question",{"text":112,"@type":113},"Conventional imaging cannot accurately predict the biological behavior needed for preoperative risk assessment. Molecular imaging can convert otherwise non-visible pathophysiological information into quantitative image features and characterize molecular-level activity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What molecular imaging capabilities support personalized therapy in GI cancers?",{"text":117,"@type":113},"Molecular imaging enables in vivo molecular tissue profiling and helps phenotype expression of single receptors and targets relevant to biological therapy. 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Although preoperative risk assessment is essential for directing patient care, its biological behavior cannot be accurately predicted by conventional imaging investigations. Potential pathophysiological information in anatomical imaging that cannot be visually identified can now be converted into high-dimensional quantitative image features thanks to the developing discipline of molecular imaging. In order to enable molecular tissue profile in vivo, molecular imaging has most recently been utilized to phenotype the expression of single receptors and targets of biological therapy. It is expected that molecular imaging will become increasingly important in the near future, driven by the expanding range of biological therapies for cancer. With this live molecular fingerprinting, molecular imaging can be utilized to drive expression-tailored customized therapy. The technical aspects of molecular imaging are first briefly discussed in this review, followed by an examination of the most recent research on the diagnosis, prognosis, and potential future clinical methods of molecular imaging for GI tract malignancies.  \nKey Words: Molecular imaging; Personalized medicine; Gastrointestinal cancers; Positron emission tomography-computed tomography  \n WJM  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 20, 2024  Volume 14  Issue 4   \nFathi M et al. Molecular imaging for GICs detection  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: In this study, we explored the important role of molecular imaging methods including single-photon emission computed tomography, positron emission tomography, magnetic resonance spectroscopy, photoacoustic imaging, magnetic resonance imaging in gastrointestinal cancers (GIC) . These techniques require a forward-looking attitude and clear objectives, which will ultimately guarantee the efficient utilization of t","cbCair5EfcqfiuFm","https://ap.wps.com/l/cbCair5EfcqfiuFm","pdf",40675535,"English","# Abstract\n# Core Tip\n# Citation\n# Key Words\n# Molecular imaging for gastrointestinal cancers\n## Technical aspects and imaging modalities\n## Diagnostic and prognostic clinical methods","[{\"question\":\"Why is molecular imaging important for gastrointestinal cancers compared with conventional imaging?\",\"answer\":\"Conventional imaging cannot accurately predict the biological behavior needed for preoperative risk assessment. Molecular imaging can convert otherwise non-visible pathophysiological information into quantitative image features and characterize molecular-level activity.\"},{\"question\":\"What molecular imaging capabilities support personalized therapy in GI cancers?\",\"answer\":\"Molecular imaging enables in vivo molecular tissue profiling and helps phenotype expression of single receptors and targets relevant to biological therapy. This supports expression-tailored customized treatment and monitoring of therapeutic effectiveness.\"},{\"question\":\"Which imaging techniques are discussed as key tools in the article?\",\"answer\":\"The review highlights methods including single-photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance spectroscopy, photoacoustic imaging, and magnetic resonance imaging for gastrointestinal cancers.\"}]","Role of molecular imaging in prognosis, diagnosis, and treatment of gastrointestinal cancers - An update on new therapeutic methods | PDF",1789991873,48]