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This retrospective observational study evaluated whether early hemoperfusion with hemoadsorption combined with multimodal care could lessen inflammation and support hemodynamic stability in pediatric patients with MOD and IAHS due to dengue shock syndrome (DSS). Five children received 4 h sessions over 1–3 days alongside multimodal therapy, with outcomes including inflammatory biomarkers and mortality.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-hemoperfusion-with-ha330-in-the-management-of-severe-dengue-shock-syndrome-research-article/444212/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-hemoperfusion-with-ha330-in-the-management-of-severe-dengue-shock-syndrome-research-article/444212.png","ImageObject",300,407,{"name":92,"@type":93},"Terk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main aim of this study in pediatric dengue shock syndrome?","Question",{"text":112,"@type":113},"To assess the therapeutic effectiveness of hemoperfusion with hemoadsorption (using HA330) combined with multimodal therapy in children with MOD and IAHS caused by DSS.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was hemoperfusion with hemoadsorption administered?",{"text":117,"@type":113},"All children received 4 hours of hemoperfusion with hemoadsorption for 1–3 consecutive days, together with multimodal therapy.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes improved after the intervention?",{"text":121,"@type":113},"Median PELOD-2 and vasoactive-inotropic score (VIS) decreased, and inflammatory biomarkers including log10 ferritin and log10 IL-6 were significantly reduced, with no additional adverse effects noted.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},444212,1790766803,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Wiley  \nJournal of Tropical Medicine  \nVolume 2026, Article ID 9928338, 8 pages [https://doi.org/10.1155/jotm/9928338](https://doi.org/10.1155/jotm/9928338)  \nResearch Article  \nRole of Hemoperfusion With HA330 in the Management of Severe Dengue Shock Syndrome  \nTananat Virojtriratana , 1 Kanruetai Na Nan ,2 and Rujipat Samransamruajkit 2  \n1 Division of Critical Care Medicine, Department of Pediatrics, Faculty of Medicine, Chiang Mai University,  \nChiang Mai, Tailand  \n2 Division of Critical Care Medicine, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University,  \nBangkok, Tailand  \nCorrespondence should be addressed to Rujipat Samransamruajkit; [rujipatrs@gmail.com](rujipatrs@gmail.com)  \nReceived 7 May 2025; Revised 4 December 2025; Accepted 19 December 2025  \nAcademic Editor: Sumi Mukhopadhyay  \nCopyright © 2026 Tananat Virojtriratana et al. Journal of Tropical Medicine published by John Wiley & Sons Ltd. Tis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nIntroduction: Infection-associated hemophagocytic syndrome (IAHS) is a rare complication in dengue infection that leads to multiple organ dysfunction (MOD) and increased mortality rates. Te early use of hemoperfusion with hemoadsorption and standard treatment may reduce infammation and prevent mortality. Tis study investigates the therapeutic efectiveness of a combination of hemoperfusion with hemoadsorption and multimodal therapy, including intravenous immunoglobulin (IVIG), corticosteroids, therapeutic plasma exchange (TPE), and/or extracorporeal organ support in pediatric patients with MOD and IAHS resulting from dengue shock syndrome (DSS) .  \nMethods: Tis retrospective observational research includes MOD and IAHS resulting from DSS. All children had 4 h of hemoperfusion with hemoadsorption for a duration of 1–3 consecutive days, accompanied by multimodal therapy. Infammatory markers and mortality rates were assessed.  \nResults: Five patients were included. All patients received hemoperfusion with hemoadsorption combined with CRRT, while four out of fve patients received IVIG, dexamethasone, and plasmapheresis. Te median PELOD-2 and vasoactive-inotropic score (VIS) decreased postintervention (8.0 vs. 6.0 and 20.0 vs. 10.0). Te median log10 serum ferritin (5.000 vs. 4.724 ng/mL, p value \u003C 0.05) and log10 serum IL-6 (3.193 vs. 2.018 pg/mL, p value \u003C 0.05) levels of the biomarker were signifcantly decreased. No additional adverse efects were noted.  \nConclusion: Te combination of hemoperfusion with hemoadsorption and multimodal therapy efectively reduced infammatory biomarkers and enhanced hemodynamic stability. Nevertheless, mortality outcomes should be assessed across larger populations.  \nKeywords: dengue shock syndrome; hemoperfusion; hemophagocytic syndrome; multiple organ dysfunction syndrome  \nHighlights  \n• Te early use of hemoperfusion with hemoadsorption can reduce infammatory cytokines in pediatric patients with MOD and IAHS due to DSS. Tis improveshemodynamic stability and might prevent eventual organ dysfunction.  \n1. Introduction  \nDengue infection is a vector-borne disease caused by Aedes aegypti that is most common in tropical and subtropical countries. Te incidence of dengue varies by nation. In Tailand, the range is from 26.7 to 100.9 per 100,000 population for dengue hemorrhagic fever (DHF) and from  \n2 Journal of Tropical Medicine  \n0.86 to 3.58 per 100,000 population for dengue shock syndrome (DSS) [1]. Most dengue infections occur in young children between the ages of 2 and 5 who live in urban areas [2] . Te disease’s clinical course can go from an asymptomatic stage to a severe one with a high risk of morbidity and mortality. Multiple organ dysfunction (MOD) such as acute kidney injury (AKI), acute liver failure (ALF), myocardial dysfunction, and IAHS are atypical manifestations of d","cbCaimZNpRR6EbsB","https://ap.wps.com/l/cbCaimZNpRR6EbsB","pdf",499357,"English","# Introduction\n## Materials and Methods\n### Ethics Statement\n## Results\n## Conclusion","[{\"question\":\"What was the main aim of this study in pediatric dengue shock syndrome?\",\"answer\":\"To assess the therapeutic effectiveness of hemoperfusion with hemoadsorption (using HA330) combined with multimodal therapy in children with MOD and IAHS caused by DSS.\"},{\"question\":\"How was hemoperfusion with hemoadsorption administered?\",\"answer\":\"All children received 4 hours of hemoperfusion with hemoadsorption for 1–3 consecutive days, together with multimodal therapy.\"},{\"question\":\"What outcomes improved after the intervention?\",\"answer\":\"Median PELOD-2 and vasoactive-inotropic score (VIS) decreased, and inflammatory biomarkers including log10 ferritin and log10 IL-6 were significantly reduced, with no additional adverse effects noted.\"}]","Role of Hemoperfusion With HA330 in the Management of Severe Dengue Shock Syndrome - Research Article | PDF",1790707231]