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This review consolidates mechanisms by which gut microbiota and bacterial metabolites regulate mucin expression and proposes emerging therapeutic strategies targeting these 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do gut microbiota influence colorectal cancer through mucins?","Question",{"text":63,"@type":64},"Gut dysbiosis disrupts mucin function, allowing microbes and bacterial metabolites to pass the intestinal epithelium and trigger host responses that can promote CRC progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What protective roles do mucins play in the intestine?",{"text":68,"@type":64},"Mucins secreted by goblet cells protect the intestinal epithelium from microorganisms and invading pathogens and provide a habitat for commensal bacteria.",{"name":70,"@type":61,"acceptedAnswer":71},"What does this review focus on?",{"text":72,"@type":64},"It summarizes how gut microbiota and bacterial metabolites regulate mucin function and expression in CRC, and it outlines novel CRC treatment strategies related to these 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\nUniversity of South Florida, United States  \nREVIEWED BY  \nCuncong Zhong,  \nUniversity of Kansas, United States Akihiko Oka,  \nShimane University, Japan  \n*CORRESPONDENCE Xiangjun Wang  \n[yzyswxj@163.com](yzyswxj@163.com)[ ](yzyswxj@163.com)Qing Ni  \n[Yzniqing@163.com](Yzniqing@163.com)[ ](Yzniqing@163.com)Yunxiang Zhu  \n[yxzhu@yzu.edu.cn](yxzhu@yzu.edu.cn)[ ](yxzhu@yzu.edu.cn)Tuo Chen  \n [chentuoysh@163.com](chentuoysh@163.com)  \n†These authors have contributed equally to this work  \nRECEIVED 09 December 2022  \nACCEPTED 03 May 2023  \nPUBLISHED 17 May 2023  \nCITATION  \nGu M, Yin W, Zhang J, Yin J, Tang X, Ling J, Tang Z, Yin W, Wang X, Ni Q, Zhu Y and Chen T (2023) Role of gut microbiota and bacterial metabolites in mucins of colorectal cancer.  \nFront. Cell. Infect. Microbiol. 13:1119992 .  \ndoi: 10.3389/fcimb.2023.1119992  \nCOPYRIGHT  \n© 2023 Gu, Yin, Zhang, Yin, Tang, Ling, Tang, Yin, Wang, Ni, Zhu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nRole of gut microbiota and bacterial metabolites in mucins of colorectal cancer  \nMing Gu †, Weixiang Yin †, Jiaming Zhang †, Junfeng Yin, Xiaofei Tang, Jie Ling, Zhijie Tang, Weijuan Yin, Xiangjun Wang*, Qing Ni*, Yunxiang Zhu* and Tuo Chen* Department of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, China  \nColorectal cancer (CRC) is a major health burden, accounting for approximately 10% of all new cancer cases worldwide. Accumulating evidence suggests that the crosstalk between the host mucins and gut microbiota is associated with the occurrence and development of CRC. Mucins secreted by goblet cells not only protect the intestinal epithelium from microorganisms and invading pathogens but also provide a habitat for commensal bacteria. Conversely, gut dysbiosis results in the dysfunction of mucins, allowing other commensals and their metabolites to pass through the intestinal epithelium, potentially triggering host responses and the subsequent progression of CRC. In this review, we summarize how gut microbiota and bacterial metabolites regulate the function and expression of mucin in CRC and novel treatment strategies for CRC.  \nKEYWORDS  \nmuc ins, gut microbiota, bacterial metabolites, bacteria-related therapies, colorectal cancer  \n1 Introduction  \nGlobally, colorectal cancer (CRC) has become a major health burden due to its higher incidence and mortality. Epidemiological data indicate that CRC ranks third in incidence with 1.9 million new cases and is the second most common cause of cancer mortality (Sunget al., 2021) . In China, over 300,000 new cases and 191,000 deaths are reported annually (Chen et al., 2016; Chen et al., 2018b) . As with many diseases, the etiology of  \nAbbreviations: CRC, colorectal cancer; IBD, inflammatory bowel disease; MUC2, mucin-2; MUC5AC, mucin-5 subtype AC; MUC5B, mucin-5B; MUC6, mucin-6; F. nucleatum, Fusobacterium nucleatum; B. fragilis, Bacteroides fragilis; ETBF, enterotoxigenic B. fragilis; S. gallolyticus, Streptococccus gallolyticus; S. bovis, Streptococcus bovis; E. coli, Escherichia coli; pks, polyketide synthase; E. faecalis, Enterococcus faecalis; SCFAs, short-chain fatty acids; BAs, bile acids; DCA, deoxycholic acid; Trp, tryptophan; AhR, aryl hydrocarbon receptor; PXR, pregnane X receptor; IPA, 3-indole-propionic acid; FMT, fecal microbiota transplantation; FOS, fructose-oligosaccharides; GOS, galacto-oligosaccharides; CDI, clostridium difficile infection.  \nFrontiers in Cellular and Infection Mic","cbCaiuS5Qazeti0M","https://ap.wps.com/l/cbCaiuS5Qazeti0M","pdf",1857869,11,"English","# Introduction\n# Gut microbiota and mucins in CRC\n## Microbiota composition and roles\n## Mucus layer as a barrier\n# Review scope and perspectives\n## Potential treatment strategies","[{\"question\":\"How do gut microbiota influence colorectal cancer through mucins?\",\"answer\":\"Gut dysbiosis disrupts mucin function, allowing microbes and bacterial metabolites to pass the intestinal epithelium and trigger host responses that can promote CRC progression.\"},{\"question\":\"What protective roles do mucins play in the intestine?\",\"answer\":\"Mucins secreted by goblet cells protect the intestinal epithelium from microorganisms and invading pathogens and provide a habitat for commensal bacteria.\"},{\"question\":\"What does this review focus on?\",\"answer\":\"It summarizes how gut microbiota and bacterial metabolites regulate mucin function and expression in CRC, and it outlines novel CRC treatment strategies related to these interactions.\"}]","Role of gut microbiota and bacterial metabolites in mucins of colorectal cancer - Review | PDF",1790258609,28]