[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-365276-105":59,"doc-detail-365276-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","role-of-gut-microbiome-in-suppression-of-cancers-review","Role of gut microbiome in suppression of cancers - Review","","The pathogenesis of cancer is closely related to disruption of human bodily homeostasis, and the gut microbiome is central to maintaining this balance across the lifespan. Dysbiosis contributes to cancer initiation, development, and prognosis by modulating host immunity and metabolism. Specific intestinal bacteria can promote oncogenesis, while others suppress cancer by inhibiting onset, delaying progression, and enhancing therapeutic effectiveness. This review summarizes the latest roles and mechanisms behind gut-microbiome-driven cancer suppression to inform prevention and treatment strategies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-gut-microbiome-in-suppression-of-cancers-review/365276/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-gut-microbiome-in-suppression-of-cancers-review/365276.png","ImageObject",300,407,{"name":92,"@type":93},"Rhys","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does the gut microbiome influence cancer suppression?","Question",{"text":113,"@type":114},"The gut microbiome helps maintain host homeostasis and can suppress oncogenesis by inhibiting cancer occurrence, delaying progression, and boosting therapeutic effects. Specific intestinal bacteria can play protective roles under certain conditions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What mechanisms connect gut dysbiosis to cancer initiation and progression?",{"text":118,"@type":114},"Dysbiosis is linked to cancer initiation, development, and prognosis by affecting the host immune system and metabolism, thereby influencing how normal cells transform into cancerous cells.",{"name":120,"@type":111,"acceptedAnswer":121},"Which factors can alter gut microbiota composition and function?",{"text":122,"@type":114},"Dietary patterns and carbohydrate intake, antibiotic exposure, aging, and environmental conditions such as infections, medication, and hygiene can significantly shape gut microbiota composition and diversity.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},365276,1790196590,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","GUT MICROBES  \n2025, VOL. 17, NO. 1, 2495183 [https://doi.org/10.1080/19490976.2025.2495183](https://doi.org/10.1080/19490976.2025.2495183)  \nREVIEW  \nRole of gut microbiome in suppression of cancers  \nYao Xu a,b*, Zhaoyu Gao a,c,d*, Jiaying Liua, Qianqian Yanga, and Shunjiang Xu a,c,d  \naCentral Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P. R. China; bDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, P. R. China; cThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, P. R. China; dHebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang, P. R. China  \nABSTRACT  \nThe pathogenesis of cancer is closely related to the disruption of homeostasis in the human body. The gut microbiome plays crucial roles in maintaining the homeostasis of its host throughout lifespan. In recent years, a large number of studies have shown that dysbiosis of the gut microbiome is involved in the entire process of cancer initiation, development, and prognosis by influencing the host immune system and metabolism. Some specific intestinal bacteria promote the occurrence and development of cancers under certain conditions. Conversely, some other specific intestinal bacteria suppress the oncogenesis and progression of cancers, including inhibiting the occurrence of cancers, delaying the progression of cancers and boosting the therapeutic effect on cancers. The promoting effects of the gut microbiome on cancers have been comprehensively discussed in the previous review. This article will review the latest advances in the roles and mechanisms of gut microbiome in cancer suppression, providing a new perspective for developing strategies of cancer prevention and treatment.  \nARTICLE HISTORY  \nReceived 14 December 2024 Revised 23 March 2025 Accepted 14 April 2025  \nKEYWORDS  \nGut microbiome; cancer; suppression  \n1. Introduction  \nThe gut microbiome, often referred to as the “second genome,” comprises a diverse population of microorganisms, including bacteria, fungi, viruses, and archaea, that reside in the human gastrointestinal tract. 1,2 The human gut is estimated to harbor over 100 trillion microbial cells, which possess a genetic repertoire, playing a vital role in human health and diseases.3 Several factors can influence the composition and function of the gut microbiota, such as dietary habits, host genetics and other host-related factors.2,4 Diet is one of the main drivers shaping the gut microbiota across the lifespan, with different dietary patterns and carbohydrate intakes having profound effects on gut microbial communities. For instance, diets rich in fats and low in fiber alter the microbial composition, reducing the abundance of short chain fatty acid (SCFA)-producing bacteria. In contrast, high-fiber diets promote the growth of beneficial microbes like Akkermansia muciniphila, which has been linked to improved intestinal  \nhealth and anti-tumorigenic effects.5 Antibiotics  \ncan significantly alter the gut microbiota by reducing microbial diversity and disrupting the balance between beneficial and harmful microbes.6 Age is another factor, as the gut microbiota dynamically changes with aging, affecting microbial composition and diversity in host.7,8 Additionally, environmental conditions such as infections, medication, and hygiene, also have strong influences on the gut bacterial community.9–11 The gut microbes are not just passive inhabitants but actively participate in various physiological processes, including digestion, metabolic regulation, and immune system function. The gut microbiome is intricately linked with human health, influencing resistance to pathogens, immune system regulation, digestion, metabolism, epithelial cell proliferation, insulin resistance, and even behavioral and neurological functions. 12 A balanced gut microbiome is crucial for maintaining the homeostasis of its host, while an imbalance, or dysbiosis of t","cbCaicF5Q4MB1jLQ","https://ap.wps.com/l/cbCaicF5Q4MB1jLQ","pdf",5284240,25,"English","# Introduction\n## Gut microbiome and homeostasis\n## Diet, antibiotics, aging, and environment as key modulators\n## Microbiome links to immunity, metabolism, and cancer risk\n# Cancer and dysregulated homeostasis","[{\"question\":\"How does the gut microbiome influence cancer suppression?\",\"answer\":\"The gut microbiome helps maintain host homeostasis and can suppress oncogenesis by inhibiting cancer occurrence, delaying progression, and boosting therapeutic effects. Specific intestinal bacteria can play protective roles under certain conditions.\"},{\"question\":\"What mechanisms connect gut dysbiosis to cancer initiation and progression?\",\"answer\":\"Dysbiosis is linked to cancer initiation, development, and prognosis by affecting the host immune system and metabolism, thereby influencing how normal cells transform into cancerous cells.\"},{\"question\":\"Which factors can alter gut microbiota composition and function?\",\"answer\":\"Dietary patterns and carbohydrate intake, antibiotic exposure, aging, and environmental conditions such as infections, medication, and hygiene can significantly shape gut microbiota composition and diversity.\"}]","Role of gut microbiome in suppression of cancers - Review | PDF",1790160530,63]