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Microbial dysbiosis contributes to oncogenesis through chronic inflammation, genotoxic metabolite production, altered bile acid metabolism, and impaired epithelial barrier integrity. The gut microbiome also modulates host responses to chemotherapy, radiotherapy, and immunotherapy, where microbial diversity and specific taxa influence efficacy and toxicity. This review synthesizes evidence across thirteen cancers with clinically relevant microbiome associations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-gut-microbiome-in-oncogenesis-and-oncotherapies/464781/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-gut-microbiome-in-oncogenesis-and-oncotherapies/464781.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does gut microbiome dysbiosis contribute to cancer development?","Question",{"text":112,"@type":113},"Dysbiosis drives chronic inflammation, produces genotoxic metabolites, alters bile acid metabolism, and can disrupt epithelial barrier integrity, thereby supporting oncogenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can the gut microbiome affect cancer treatment outcomes?",{"text":117,"@type":113},"The microbiome modulates host responses to chemotherapy, radiotherapy, and especially immunotherapy, where microbial diversity and specific taxa determine treatment efficacy and toxicity.",{"name":119,"@type":110,"acceptedAnswer":120},"What microbiome-based strategies are discussed for future cancer care?",{"text":121,"@type":113},"The review discusses emerging approaches to modify the microbiome, including dietary interventions, probiotics, and fecal microbiota transplantation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},464781,1790906145,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Review  \nRole of Gut Microbiome in Oncogenesis and Oncotherapies  \nRenuka Sri Sai Peddireddi 1,†, Sai Kiran Kuchana 2,†, Rohith Kode 2, Saketh Khammammettu 3,  \nAishwarya Koppanatham 4, Supriya Mattigiri 5, Harshavardhan Gobburi 6 and Suresh K. Alahari 7, *  \nAcademic Editor: Maria Gazouli  \nReceived: 18 November 2025  \nRevised: 23 December 2025  \nAccepted: 27 December 2025  \nPublished: 29 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Mansfield Kaseman Health Clinic, Rockville, MD 20850, USA; 16770700@igmcri.edu.in  \n2 Department of Internal Medicine, Kakatiya Medical College, Warangal 506007, India; [saikirankuchana03@gmail.com](saikirankuchana03@gmail.com) (S.K.K.); [koderohith4@gmail.com](koderohith4@gmail.com) (R.K.)  \n3 Apollo Institute of Medical Sciences and Research, Hyderabad 500096, India; [saketh0803@gmail.com](saketh0803@gmail.com)  \n4 Andhra Medical College, Visakhapatnam 530002, India; [aishwaryakoppanatham@gmail.com](aishwaryakoppanatham@gmail.com)  \n5 Katuri Medical College and Hospital, Guntur 522019, India; [supriyamattigiri@gmail.com](supriyamattigiri@gmail.com)  \n6 Department of Internal Medicine, Osmania Medical College, Hyderabad 500095, India; [vharsha811@gmail.com](vharsha811@gmail.com)  \n7 Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center at New Orleans, New Orleans, LA 70112, USA  \n* Correspondence: [salaha@lsuhsc.edu](salaha@lsuhsc.edu)[ ](salaha@lsuhsc.edu)† These authors contributed equally to this work.  \nSimple Summary  \nThe gut microbiome, which consists of trillions of microorganisms living in the human digestive tract, plays an important role in regulating immunity, metabolism, and inflammation. Growing evidence suggests that disruptions in this microbial community may influence how cancers develop and how patients respond to cancer treatments. In this review, we summarize current research linking the gut microbiome to thirteen common cancers, including cancers of the gastrointestinal tract and cancers affecting other organs such as the breast, lung, brain, and skin. We highlight how certain microbes may promote cancer-related inflammation or DNA damage, while others appear to support immune responses that improve the effectiveness of cancer therapies, particularly immunotherapy. We also discuss emerging strategies aimed at modifying the microbiome, such as diet, probiotics, and fecal microbiota transplantation, and their potential role in future cancer care. Overall, this review provides an accessible overview of how the gut microbiome may influence cancer development and treatment.  \nAbstract  \nThe gut microbiome has emerged as a key regulator of human health, influencing not only metabolism and immunity but also the development and treatment of cancer. Mounting evidence suggests that microbial dysbiosis contributes to oncogenesis by driving chronic inflammation, producing genotoxic metabolites, altering bile acid metabolism, and disrupting epithelial barrier integrity. At the same time, the gut microbiome significantly modulates the host response to oncotherapies including chemotherapy, radiotherapy, and especially immunotherapy, where microbial diversity and specific taxa determine treatment efficacy and toxicity. This review synthesizes current evidence on the role of the gut microbiome in both oncogenesis and oncotherapies, focusing on thirteen cancers with the strongest and most clinically relevant microbiome associations, colorectal cancer, gastric cancer, hepatocellular carcinoma, gallbladder cancer, esophageal cancer, pancreatic cancer, oral squamous cell carcinoma, cervical cancer, prostate cancer, breast cancer, lung cancer, brain cancer, and melanoma. These cancers were selected based on robust mechanistic data linking microbial alterations to tumor initiat","cbCaicKbrmOiayiH","https://ap.wps.com/l/cbCaicKbrmOiayiH","pdf",2266718,23,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"How does gut microbiome dysbiosis contribute to cancer development?\",\"answer\":\"Dysbiosis drives chronic inflammation, produces genotoxic metabolites, alters bile acid metabolism, and can disrupt epithelial barrier integrity, thereby supporting oncogenesis.\"},{\"question\":\"How can the gut microbiome affect cancer treatment outcomes?\",\"answer\":\"The microbiome modulates host responses to chemotherapy, radiotherapy, and especially immunotherapy, where microbial diversity and specific taxa determine treatment efficacy and toxicity.\"},{\"question\":\"What microbiome-based strategies are discussed for future cancer care?\",\"answer\":\"The review discusses emerging approaches to modify the microbiome, including dietary interventions, probiotics, and fecal microbiota transplantation.\"}]","Role of Gut Microbiome in Oncogenesis and Oncotherapies | PDF",1790768647,58]