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This review summarizes how forkhead-box gene family members—known for driving tumor growth and progression—contribute to breast cancer biology through genetic mutations and key regulatory pathways. 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Alkhalil 3, Ahad Amer Alsaiari 4, Amal F. Gharib 4, Hayaa M. Alhuthali 4, Shanika Rana 5, Abdulaziz A. Aloliqi 6, Alaa Abdulaziz Eisa 7, Mohammad Raghibul Hasan 8 and Kapil Dev 1, *  \nCitation: Sadaf; Hazazi, A.; Alkhalil, S.S.; Alsaiari, A.A.; Gharib, A.F.; Alhuthali, H.M.; Rana, S.; Aloliqi, A.A.; Eisa, A.A.; Hasan, M.R.; et al. Role of Fork-Head Box Genes in Breast Cancer: From Drug Resistance to Therapeutic Targets. Biomedicines 2023, 11, 2159. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/biomedicines11082159](10.3390/biomedicines11082159)  \nAcademic Editor: Myunggon Ko  \nReceived: 17 June 2023  \nRevised: 17 July 2023  \nAccepted: 25 July 2023  \nPublished: 1 August 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India; [sadaf924@gmail.com](sadaf924@gmail.com)  \n2 Department of Pathology and Laboratory Medicine, Security Forces Hospital Program, Riyadh 11481, Saudi Arabia; [ahazazi@sfh.med.sa](ahazazi@sfh.med.sa)  \n3 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Alquwayiyah 11961, Saudi Arabia; [salkhalil@su.edu.sa](salkhalil@su.edu.sa)  \n4 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia; [ahadamer@tu.edu.sa](ahadamer@tu.edu.sa) (A.A.A.); [amgharib@tu.edu.sa](amgharib@tu.edu.sa) (A.F.G.); [hmhuthali@tu.edu.sa](hmhuthali@tu.edu.sa) (H.M.A.)  \n5 School of Biosciences, Apeejay Stya University, Gurugram 122003, India; [ranashanika29@gmail.com](ranashanika29@gmail.com)  \n6 Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia; [aaalieky@qu.edu.sa](aaalieky@qu.edu.sa)  \n7 Department of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Medina 30002, Saudi Arabia; [aeisa@taibahu.edu.sa](aeisa@taibahu.edu.sa)  \n8 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Riyadh 15342, Saudi Arabia; [malhasn@su.edu.sa](malhasn@su.edu.sa)  \n* Correspondence: [kdev@jmi.ac.in](kdev@jmi.ac.in)  \nAbstract: Breast cancer has been acknowledged as one of the most notorious cancers, responsible for millions of deaths around the globe. Understanding the various factors, genetic mutations, comprehensive pathways, etc., that are involved in the development of breast cancer and how these affect the development of the disease is very important for improving and revitalizing the treatment of this global health issue. The forkhead-box gene family, comprising 19 subfamilies, is known to have a significant impact on the growth and progression of this cancer. The article looks into the various forkhead genes and how they play a role in different types of cancer. It also covers their impact on cancer drug resistance, interaction with microRNAs, explores their potential as targets for drug therapies, and their association with stem cells.  \nKeywords: forkhead genes; forkhead proteins; FOXA; FOXM1; FOXC; FOXO; FOXP; miRNAs; drug resistance; stem cells; breast cancer  \n1. Introduction  \nGlobally, breast cancer has been known to be the second biggest cause of fatalities in women, and it is also the most often diagnosed malignancy. Although technology and research, in the past few decades, have enabled better and more effective treatment, coupled with early diagnosis, a copious number of patients have been known tobe resistant to current t","cbCaigDE1kMXjMfN","https://ap.wps.com/l/cbCaigDE1kMXjMfN","pdf",2503445,"English","# Abstract\n# Keywords\n# Introduction\n## Breast cancer burden and treatment resistance\n## Molecular uniqueness and genetic drivers\n# Forkhead gene family overview","[{\"question\":\"What is the central focus of the review?\",\"answer\":\"The review focuses on forkhead-box genes in breast cancer and how they connect cancer development to drug resistance and therapeutic targeting.\"},{\"question\":\"How do forkhead-box genes influence breast cancer progression?\",\"answer\":\"Forkhead-box gene family members are described as regulators of cell proliferation, differentiation, cell-cycle control, and DNA repair pathways, contributing to growth and progression.\"},{\"question\":\"Which mechanisms related to therapy are discussed?\",\"answer\":\"The article discusses how forkhead genes impact cancer drug resistance, interact with microRNAs, and relate to stem cells, supporting their potential as drug-therapy targets.\"}]","Role of Fork-Head Box Genes in Breast Cancer - From Drug Resistance to Therapeutic Targets | PDF",1790245576,48]