[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377380-105":59,"doc-detail-377380-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","role-of-fisetin-in-selected-malignant-neoplasms-in-women","Role of Fisetin in Selected Malignant Neoplasms in Women","","Naturally derived fisetin offers a promising therapeutic window and cost-effectiveness for women’s cancers. Fisetin, a flavonol flavonoid found in fruit and vegetables, is increasingly studied for broad pharmacological properties, including cytotoxic activity against prevalent tumors. By modulating selected molecular targets and biochemical processes, fisetin may reduce metastasis and slow cancer progression, supporting chemotherapeutic and chemopreventive roles. This review summarizes in vitro and in vivo evidence on anticancer effects in breast, cervical, and ovarian malignancies and highlights nanodelivery systems to improve bioavailability and solubility, while emphasizing the need for large-scale clinical trials.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-fisetin-in-selected-malignant-neoplasms-in-women/377380/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-fisetin-in-selected-malignant-neoplasms-in-women/377380.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is fisetin and why is it relevant to cancer research?","Question",{"text":112,"@type":113},"Fisetin is a natural flavonol flavonoid found in fruit and vegetables. It has been studied for broad pharmacological properties, including cytotoxic activity against common cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which female cancers are covered in the review?",{"text":117,"@type":113},"The review summarizes anticancer evidence for breast, cervical, and ovarian cancers, using both in vitro and in vivo studies.",{"name":119,"@type":110,"acceptedAnswer":120},"How might fisetin affect cancer progression?",{"text":121,"@type":113},"Fisetin may stimulate or inhibit molecular targets and biochemical processes that influence metastasis and progression. It is discussed in relation to apoptosis induction, proliferation inhibition, and modulation of inflammatory and mitochondrial functions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377380,1790469058,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","nutrients   \nReview  \nRole of Fisetin in Selected Malignant Neoplasms in Women  \nAnna Markowska 1, Michał Antoszczak 2, Karol Kacprzak 2, Janina Markowska 3 and Adam Huczy ´nski 2, *  \nCitation: Markowska, A.;  \nAntoszczak, M.; Kacprzak, K.; Markowska, J.; Huczy ´nski, A. Role of Fisetin in Selected Malignant Neoplasms in Women. Nutrients 2023, 15, 4686. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)nu15214686  \nAcademic Editor: Mariusz Chabowski  \nReceived: 9 October 2023  \nRevised: 31 October 2023  \nAccepted: 3 November 2023  \nPublished: 5 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Perinatology and Women's Health, Pozna ´n University of Medical Sciences, 60-535 Pozna ´n, Poland; [annamarkowska@vp.pl](annamarkowska@vp.pl)  \n2 Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, 61-614 Pozna ´n, Poland; [michant@amu.edu.pl](michant@amu.edu.pl) (M.A.); [karol.kacprzak@gmail.com](karol.kacprzak@gmail.com) (K.K.)  \n3 Gynecological Oncology Center, Pozna ´nska 58A, 60-850 Pozna ´n, Poland; [jmarkmed@poczta.onet.pl](jmarkmed@poczta.onet.pl)  \n* Correspondence: [adhucz@amu.edu.pl](adhucz@amu.edu.pl)  \nAbstract: A promising therapeutic window and cost-effectiveness are just two of the potential advantages of using naturally derived drugs. Fisetin (3,30,40,7-tetrahydroxyflavone) is a natural flavonoid of the flavonol group, commonly found in fruit and vegetables. In recent years, fisetin has gained wide attention across the scientific community because of its broad spectrum of pharmacological properties, including cytotoxic activity against most abundant cancers. By stimulating or inhibiting selected molecular targets or biochemical processes, fisetin could affect the reduction of metastasis or cancer progression, which indicates its chemotherapeutic or chemopreventive role. In this review, we have summarized the results of studies on the anticancer effects of fisetin on selected female malignancies, both in in vitro and in vivo tests, i.e., breast, cervical, and ovarian cancer, published over the past two decades. Until now, no article dedicated exclusively to the action of fisetin on female malignancies has appeared. This review also describes a growing number of nanodelivery systems designed to improve the bioavailability and solubility of this natural compound. The reported low toxicity and activity of fisetin on cancer cells indicate its valuable potential, but large-scale clinical trials are urgently needed to assess real chemotherapeutic efficacy of this flavonoid.  \nKeywords: fisetin; flavonoids; flavonols; breast cancer; cervical cancer; ovarian cancer; in vitro activity; in vivo activity; nanodelivery systems  \n1. Introduction  \nMalignant neoplasms of the genital organs are a significant cause of death among women worldwide, leading to a decrease in average life expectancy [1] . Despite significant advances in both clinical trials and the use of the so-called targeted drugs, the quest for new anticancer agents with high efficacy and low toxicity is continued to prolong and improve the quality of life of female cancer patients [2–4] . Oxidative stress, hypoxia, genetic mutations and the lack of apoptotic function are the main internal causes of cancer [5] . Among the promising candidates for new anticancer agents are flavonoids. Both anti-and pro-oxidant properties of flavonoids under normal or pathological conditions, respectively, may be involved in their beneficial effects against cancer, leading to the activation of apoptosis or inhibition of proliferation as well as inflammation [6] . Flavonoid compounds may activate cancer cell death ","cbCaipKY4uPhMcaS","https://ap.wps.com/l/cbCaipKY4uPhMcaS","pdf",1508404,14,"English","# Abstract\n# Introduction\n## Malignant neoplasms and need for new anticancer agents\n## Oxidative stress, hypoxia, mutations, and apoptosis dysfunction\n## Flavonoids as candidates for chemoprevention and anticancer activity","[{\"question\":\"What is fisetin and why is it relevant to cancer research?\",\"answer\":\"Fisetin is a natural flavonol flavonoid found in fruit and vegetables. It has been studied for broad pharmacological properties, including cytotoxic activity against common cancers.\"},{\"question\":\"Which female cancers are covered in the review?\",\"answer\":\"The review summarizes anticancer evidence for breast, cervical, and ovarian cancers, using both in vitro and in vivo studies.\"},{\"question\":\"How might fisetin affect cancer progression?\",\"answer\":\"Fisetin may stimulate or inhibit molecular targets and biochemical processes that influence metastasis and progression. It is discussed in relation to apoptosis induction, proliferation inhibition, and modulation of inflammatory and mitochondrial functions.\"}]","Role of Fisetin in Selected Malignant Neoplasms in Women | PDF",1790224700,35]