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Exosomes, extracellular vesicles present in virtually all body fluids, function as key mediators of intercellular communication and contribute to tumor biology by reshaping the tumor microenvironment, promoting metastasis, and modulating immune responses. This review synthesizes mechanisms linking exosome cargo and signaling to SGT occurrence and progression, and evaluates their use as diagnostic and prognostic biomarkers. It also discusses exosome-based liquid biopsies and analytical methods supported by biosensors and artificial intelligence, aiming for non-invasive, real-time cancer profiling and improved patient outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-exosomes-in-salivary-gland-tumors-and-technological-advances-in-their-assessment-review/331395/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-exosomes-in-salivary-gland-tumors-and-technological-advances-in-their-assessment-review/331395.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are salivary gland tumors difficult to diagnose and treat?","Question",{"text":112,"@type":113},"Salivary gland tumors are rare and diverse, making diagnosis and management challenging due to their rarity and complexity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles do exosomes play in salivary gland tumor biology?",{"text":117,"@type":113},"Exosomes mediate cell-to-cell communication and influence tumor biology by modulating the tumor microenvironment, supporting metastasis, and affecting immune responses.",{"name":119,"@type":110,"acceptedAnswer":120},"How can exosome-based liquid biopsies improve clinical care for SGT patients?",{"text":121,"@type":113},"Exosome-based liquid biopsies can enable non-invasive, real-time systemic profiling for diagnosis and prognosis, supporting precision and personalized medicine approaches.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331395,1790901522,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","cancers   \nReview  \nRole of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment  \nArtur Nieszporek 1, Małgorzata Wierzbicka 2,3, Natalia Labedz 1, Weronika Zajac 4,5, Joanna Cybinska 4,5 and Patrycja Gazinska 1, *  \nCitation: Nieszporek, A.; Wierzbicka, M.; Labedz, N.; Zajac, W.; Cybinska, J.; Gazinska, P. Role of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment. Cancers 2024, 16, 3298 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers16193298  \nAcademic Editor: Judith E. Raber-Durlacher  \nReceived: 14 August 2024  \nRevised: 17 September 2024  \nAccepted: 19 September 2024  \nPublished: 27 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Biobank Research Group, Łukasiewicz Research Network–PORT Polish Centre for Technology Development, Stablowicka Street 147, 54-066 Wroclaw, Poland  \n2 Institute of Human Genetics Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland  \n3 Department of Otolaryngology, Regional Specialist Hospital Wroclaw, Research & Development Centre, Kamienskiego Street 73a, 51-124 Wroclaw, Poland  \n4 Faulty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw, Poland  \n5 Materials Science and Engineering Center, Łukasiewicz Research Network–PORT Polish Centre for Technology Development, Stablowicka Street 147, 54-066 Wroclaw, Poland  \n* [Correspondence: patrycja.gazinska@port.lukasiewicz.gov.pl](Correspondence: patrycja.gazinska@port.lukasiewicz.gov.pl)  \nSimple Summary: Salivary gland tumors (SGTs) are rare and complex, making them difficult to diagnose and treat. This work focuses on the role of exosomes, extracellular vesicles secreted by almost all cell types, in the development and progression of SGT. Exosomes are crucial in cell-tocell communication and play significant roles in tumor biology, including modulating the tumor environment, aiding metastasis, and affecting immune responses. A better understanding of exosome biology can lead to their use as biomarkers for diagnosis and prognosis, as well as targets for treatment, potentially transforming SGT management and improving patient outcomes. Exosome-based liquid biopsies could offer non-invasive, real-time diagnostics and enhance patient care through precision medicine. This review explores the advancements in salivary exosome analysis, highlighting its potential for non-invasive cancer detection and the development of innovative diagnostic techniques.  \nAbstract: Backgroud: Salivary gland tumors (SGTs) are rare and diverse neoplasms, presenting significant challenges in diagnosis and management due to their rarity and complexity. Exosomes, lipid bilayer vesicles secreted by almost all cell types and present in all body fluids, have emerged as crucial intercellular communication agents. They play multifaceted roles in tumor biology, including modulating the tumor microenvironment, promoting metastasis, and influencing immune responses. Results: This review focuses on the role of exosomes in SGT, hypothesizing that novel diagnostic and therapeutic approaches can be developed by exploring the mechanisms through which exosomes influence tumor occurrence and progression. By understanding these mechanisms, we can leverage exosomes as diagnostic and prognostic biomarkers, and target them for therapeutic interventions. The exploration of exosome-mediated pathways contributing to tumor progression and metastasis could lead to more effective treatments, transforming the management of SGT and improving patient outcomes. Ongoing research aims to elucidate the specific cargo and signaling pathways involved in ex","cbCainhbs2hFbVTc","https://ap.wps.com/l/cbCainhbs2hFbVTc","pdf",605231,"English","# Introduction\n# Role of Exosomes in Salivary Gland Tumors\n# Exosome-Based Liquid Biopsies and Diagnostic Technologies\n# Conclusions","[{\"question\":\"Why are salivary gland tumors difficult to diagnose and treat?\",\"answer\":\"Salivary gland tumors are rare and diverse, making diagnosis and management challenging due to their rarity and complexity.\"},{\"question\":\"What roles do exosomes play in salivary gland tumor biology?\",\"answer\":\"Exosomes mediate cell-to-cell communication and influence tumor biology by modulating the tumor microenvironment, supporting metastasis, and affecting immune responses.\"},{\"question\":\"How can exosome-based liquid biopsies improve clinical care for SGT patients?\",\"answer\":\"Exosome-based liquid biopsies can enable non-invasive, real-time systemic profiling for diagnosis and prognosis, supporting precision and personalized medicine approaches.\"}]","Role of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment - Review | PDF",1789993112]