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Key limitations include restricted specialized expertise and operator-dependent variability, though ongoing technique refinement suggests an expanding role in pancreatic cancer care.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/role-of-endoscopic-ultrasound-in-pancreatic-cancer-diagnosis-and-management/332138/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/role-of-endoscopic-ultrasound-in-pancreatic-cancer-diagnosis-and-management/332138.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How does endoscopic ultrasound influence pancreatic cancer diagnosis and care?","Question",{"text":63,"@type":64},"EUS improves diagnostic accuracy, enables precise staging, and supports therapeutic and palliative interventions for pancreatic cancer and its sequelae.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What challenges limit the use of EUS in current practice?",{"text":68,"@type":64},"Use is constrained by limited specialized expertise and variability in operator proficiency.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is EUS considered valuable compared with CT or MRI?",{"text":72,"@type":64},"EUS is described as more sensitive for detecting pancreatic lesions, including lesions smaller than 2 cm, and can detect preinvasive neoplasms in selected patients.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332138,1790930156,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","diagnostics  \nReview  \nRole of Endoscopic Ultrasound in Pancreatic Cancer Diagnosis and Management  \nHayley K. Rogers 1 and Shawn L. Shah 2, *  \nCitation: Rogers, H.K.; Shah, S.L. Role of Endoscopic Ultrasound in Pancreatic Cancer Diagnosis and Management. Diagnostics 2024, 14, 1156. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)diagnostics14111156  \nAcademic Editor: Antonio Facciorusso  \nReceived: 19 March 2024  \nRevised: 22 May 2024  \nAccepted: 27 May 2024  \nPublished: 31 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA  \n2 Division of Digestive and Liver Diseases, Dallas VA Medical Center, VA North Texas Healthcare System, Dallas, TX 75216, USA  \n* Correspondence: [shawn.shah@utsouthwestern.edu](shawn.shah@utsouthwestern.edu)  \nAbstract: The emergence of endoscopic ultrasound (EUS) has significantly impacted the diagnosis and management of pancreatic cancer and its associated sequelae. While the definitive role of EUS for pancreatic cancer remains incompletely characterized by currently available guidelines, EUS undoubtedly offers high diagnostic accuracy, the precise staging of pancreatic neoplasms, and the ability to perform therapeutic and palliative interventions. However, current challenges to EUS include limited specialized expertise and variability in operator proficiency. As the technology and techniques continue to evolve and become more refined, EUS is poised to play an increasingly integral role in shaping pancreatic cancer care.  \nKeywords: endoscopic ultrasound; pancreatic ductal adenocarcinoma; endoscopic ultrasound-guided interventions; celiac plexus neurolysis  \n1. Introduction  \nDespite significant advances in imaging technology and precision medicine, pancreatic cancer remains a formidable disease with significant morbidity and mortality. It is among the deadliest cancers in the United States, estimated to compose 8.3% of all cancer-related deaths with a 12.5% five-year survival rate [1] . It is projected that the number of deaths due to pancreatic cancer are set to continue to increase and become the second-highest cause of cancer-related deaths by 2030 [2] . Patients with pancreatic ductal adenocarcinoma (PDAC)—the most common subtype of pancreatic cancer—often present with advanced disease due to the largely asymptomatic nature in the early phase and lack of universal screening modalities in average-risk patients. Approximately 80–85% of patients have unresectable cancer at diagnosis, with symptoms that may include jaundice with or without abdominal pain, unintentional weight loss, and cachexia. With a rise in incidence over the past 20 years, early detection remains crucial for improving patient outcomes, as surgical resection can be curative. Various clinical pathways exist for managing PDAC, ranging from surgical resection with preoperative computed tomography (CT) imaging or magnetic resonance imaging (MRI) with or without biopsy confirmation to neoadjuvant therapy to palliation. Endoscopic ultrasound (EUS) has evolved as an impactful and versatile tool in managing pancreatic cancer and its associated sequelae; however, the optimal utilization of EUS as a diagnostic and therapeutic modality remains unclear per currently available guidelines. Here, we aim to review the role of EUS as a diagnostic, therapeutic, and palliative instrument for pancreatic cancer care.  \n2. Diagnostic Versatility of Endoscopic Ultrasound  \nOver the past 40 years, EUS has evolved from a diagnostic modality to one with wide-ranging therapeutic offerings [3] . En","cbCaih2KgXZR2cbM","https://ap.wps.com/l/cbCaih2KgXZR2cbM","pdf",911264,13,"English","# 1. Introduction\n# 2. Diagnostic Versatility of Endoscopic Ultrasound\n## Endoscopic ultrasound as an essential diagnostic and management tool\n## EUS sensitivity and detection of small lesions\n## Role in surveillance for high-risk patients\n## EUS in TNM staging and clinical decision-making","[{\"question\":\"How does endoscopic ultrasound influence pancreatic cancer diagnosis and care?\",\"answer\":\"EUS improves diagnostic accuracy, enables precise staging, and supports therapeutic and palliative interventions for pancreatic cancer and its sequelae.\"},{\"question\":\"What challenges limit the use of EUS in current practice?\",\"answer\":\"Use is constrained by limited specialized expertise and variability in operator proficiency.\"},{\"question\":\"Why is EUS considered valuable compared with CT or MRI?\",\"answer\":\"EUS is described as more sensitive for detecting pancreatic lesions, including lesions smaller than 2 cm, and can detect preinvasive neoplasms in selected patients.\"}]","Role of Endoscopic Ultrasound in Pancreatic Cancer Diagnosis and Management | PDF",1789996970,33]