[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-326980-105":59,"doc-detail-326980-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","role-of-chromosomal-cohesion-and-separation-in-aneuploidy-and-tumorigenesis","Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis","","Cell division relies on accurate chromosome copying and strict pairing of each newly replicated chromosome with its identical sister. This cohesion is sustained by the cohesin protein complex, which encircles DNA to keep sister chromatids joined until segregation. Cohesin removal driven by Separase enables the metaphase-to-anaphase transition and preserves genomic stability. When cohesion or separation is dysregulated, abnormal chromosome numbers (aneuploidy) emerge and strongly correlate with diverse cancers through cohesin-related defects.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/role-of-chromosomal-cohesion-and-separation-in-aneuploidy-and-tumorigenesis/326980/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/role-of-chromosomal-cohesion-and-separation-in-aneuploidy-and-tumorigenesis/326980.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does the cohesin complex play during cell division?","Question",{"text":113,"@type":114},"Cohesin maintains sister chromatid cohesion by encircling DNA, holding replicated chromosomes together until metaphase.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the metaphase-to-anaphase transition occur?",{"text":118,"@type":114},"The transition requires dissolution of cohesin by the enzyme Separase, allowing sister chromatids to separate.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is aneuploidy important in cancer development?",{"text":122,"@type":114},"Dysregulated chromosomal cohesion and separation can produce an abnormal chromosome count (aneuploidy), which is strongly associated with many cancer types.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},326980,1790163501,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Cellular and Molecular Life Sciences (2024) 81:100  \n[https://doi.org/10.1007/s00018-024-05122-5](https://doi.org/10.1007/s00018-024-05122-5) Cellular and Molecular Life Sciences  \nRole of chromosomal cohesion and separation in aneuploidy and tumorigenesis  \nDebananda Pati1  \nReceived: 13 November 2023 / Revised: 28 December 2023 / Accepted: 9 January 2024 © The Author(s) 2024  \nAbstract  \nCell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organized into structures called chromosomes. Before a cell can divide into two, it needs to ensure that each newly copied chromosome is paired tightly with its identical twin. This pairing is maintained by a protein complex known as cohesin, which is conserved in various organisms, from single-celled ones to humans. Cohesin essentially encircles the DNA, creating a ring-like structure to handcuff, to keep the newly synthesized sister chromosomes together in pairs. Therefore, chromosomal cohesion and separation are fundamental processes governing the attachment and segregation of sister chromatids during cell division. Metaphase-to-anaphase transition requires dissolution of cohesins by the enzyme Separase. The tight regulation of these processes is vital for safeguarding genomic stability. Dysregulation in chromosomal cohesion and separation resulting in aneuploidy, a condition characterized by an abnormal chromosome count in a cell, is strongly associated with cancer. Aneuploidy is a recurring hallmark in many cancer types, and abnormalities in chromosomal cohesion and separation have been identified as significant contributors to various cancers, such as acute myeloid leukemia, myelodysplastic syndrome, colorectal, bladder, and other solid cancers. Mutations within the cohesin complex have been associated with these cancers, as they interfere with chromosomal segregation, genome organization, and gene expression, promoting aneuploidy and contributing to the initiation of malignancy. In summary, chromosomal cohesion and separation processes play a pivotal role in preserving genomic stability, and aberrations in these mechanisms can lead to aneuploidy and cancer. Gaining a deeper understanding of the molecular intricacies of chromosomal cohesion and separation offers promising prospects for the development of innovative therapeutic approaches in the battle against cancer.  \nKeywords Cohesin · Cancer · Chromosomal instability · Separase · Rad21 · Stag2  \nIntroduction  \nCells serve as the fundamental units of our bodies, and they divide through complex processes like mitosis and meiosis. These processes involve a series of intricate steps that culminate in the replication and separation of the cell’s genetic material with very high fidelity, ultimately yielding two genetically identical daughter cells [1] .  \nA critical aspect of mitosis is the faithful replication of the cell’s DNA during the S phase. Following this, sister  \n* Debananda Pati [pati@bcm.edu](pati@bcm.edu)  \n1 Texas Children’s Cancer Center, Department of Pediatrics Hematology/Oncology, Molecular and Cellular Biology, Baylor College of Medicine, 1102 Bates Avenue, Houston, TX 77030, USA  \nchromatids, which are pairs of replicated chromosomes, are held together by a remarkable group of proteins known asthe cohesin complex [2] . This complex acts as a molecular glue, maintaining the cohesion of sister chromatids until the metaphase of cell division [3–5] . During the transition from metaphase to anaphase, the replicated chromosomes are meticulously separated after the removal of the cohesin complex [6 , 7] . This process ensures the precise distribution of genetic material into each daughter cell [8] . Any malfunction in this process can result in chromosomal anomalies leading to abnormal chromosome content, known as aneuploidy, and more likely to result in cell death. However, the cells that overcome the aneuploidy stress can result in uncontrolled cell growth, a d","cbCaibFQ4ntxUcRT","https://ap.wps.com/l/cbCaibFQ4ntxUcRT","pdf",811668,13,"English","# Abstract\n# Introduction\n# Sister chromatid cohesion and separation\n## Discovery of cohesin\n## Composition of cohesin complex and its function","[{\"question\":\"What role does the cohesin complex play during cell division?\",\"answer\":\"Cohesin maintains sister chromatid cohesion by encircling DNA, holding replicated chromosomes together until metaphase.\"},{\"question\":\"How does the metaphase-to-anaphase transition occur?\",\"answer\":\"The transition requires dissolution of cohesin by the enzyme Separase, allowing sister chromatids to separate.\"},{\"question\":\"Why is aneuploidy important in cancer development?\",\"answer\":\"Dysregulated chromosomal cohesion and separation can produce an abnormal chromosome count (aneuploidy), which is strongly associated with many cancer types.\"}]","Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis | PDF",1789975903,33]