[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-124490-en":3,"doc-seo-124490-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},124490,13056703020460,"Valentina","https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923",8,"Research & Report","Robust Prediction and Biomarker Discovery in Rare Cancers Using Interpretable Machine Learning - thesis","Rare cancers such as glioblastoma multiforme (GBM) create persistent challenges in computational oncology because limited data, biological noise, and the difficulty of finding disease-specific molecular signatures undermine standard modeling. Contrary to the expectation of poor rare-cancer performance, machine learning on genomic data achieves strong accuracy, raising the need to distinguish genuine biology from artifacts. This thesis builds an interpretable framework to test predictive robustness and extract biologically meaningful biomarkers under extreme class imbalance, using cascade learning, SHAP interpretability, and Tab2Image visualization, with emphasis on transparency and accountability in scarce-data settings.","©Copyright 2025 Dhurka Rohini Madasamy  \nRobust Prediction and Biomarker Discovery in Rare Cancers Using  \nInterpretable Machine Learning  \nDhurka Rohini Madasamy  \nA thesis  \nsubmitted in partial fulfillment of the  \nrequirements for the degree of  \nMaster of Science  \nUniversity of Washington  \n2025  \nCommittee:  \nWooyoung Kim  \nMunehiro Fukuda  \nBill Erdly  \nProgram Authorized to Offer Degree:  \nComputer Science & Software Engineering  \nUniversity of Washington  \nAbstract  \nRobust Prediction and Biomarker Discovery in Rare Cancers Using Interpretable Machine  \nLearning  \nDhurka Rohini Madasamy  \nChair of the Supervisory Committee:  \nWooyoung Kim  \nDepartment of Computing and Software Systems  \nRare cancers such as Glioblastoma Multiforme (GBM, a rare brain cancer) pose persistent challenges in computational oncology due to limited data, biological noise, and difficulty in isolating disease-specific molecular signatures. Based on these constraints, this work began with the expectation that rare-cancer models would perform poorly. However, machine learning approaches on genomic data achieved unexpectedly strong accuracy, motivating investigation into whether this separability reflected genuine biology or artifactual signal. This thesis develops an interpretable machine learning framework that evaluates predictive robustness and isolates biologically meaningful biomarkers under extreme imbalance. Cascade Learning systematically removes broad cancer pathways and reveals biomarkers uniquely associated with the rare cancer, while SHAP-based interpretability aligns these genes with experimentally reported glioma biology. Complementary Tab2Image visualizations provide spatial confirmation of class separability, strengthening biological trust in the learned signal. Overall, this work provides a robust, biologically grounded, and ethically aligned pathway for rare-cancer biomarker discovery that emphasizes transparency, fairness, and accountability in scarce-data environments.  \nTABLE OF CONTENTS  \nPage  \nAbstract ........................................... i  \nTable of Contents ...................................... ii  \nList of Figures ....................................... iii  \nList [of Tables ........................................ vi](of Tables ........................................ vi)  \n[Glossary ........................................... vii](Glossary ........................................... vii)  \n[Acknowledgements ..................................... x](Acknowledgements ..................................... x)  \n[Dedication .......................................... xi](Dedication .......................................... xi)  \n[Chapter 1: Introduction ................................ 1](Chapter 1: Introduction ................................ 1)  \n[1.1 Context and Motivation ............................. 1](1.1 Context and Motivation ............................. 1)  \n[1.2 Problem Statement ................................ 3](1.2 Problem Statement ................................ 3)  \n[1.3 Research Question](1.3 Research Question), [Motivation](Motivation), [and Approach](and Approach) ................. 4  \n1.4 Thesis Contributions ............................... 4  \nChapter 2: Related Work ................................ 5  \n2.1 Machine Learning in Rare Cancer Prediction .................. 5  \n2.2 Interpretable Machine Learning for Transparency ............... 6  \n2.3 Multi-Stage and Cascade Learning Approaches ................. 7  \n2.4 Summary ..................................... 7  \nChapter 3: Methodology ................................ 8  \n3.1 Overview ...................................... 8  \n3.2 Architecture and Technologies .......................... 9  \n3.3 Gene Expression Data Sources and Provenance ................ 9  \n3.4 Dataset Size Summary .............................. 10  \n3.5 Exploratory Data Analysis (EDA) ........................ 12  \n3.6 Data Preprocessing ................................","cbCaikxoadH8hmjG","https://ap.wps.com/l/cbCaikxoadH8hmjG","pdf",9191709,1,91,"English","en",105,"# Abstract\n# Introduction\n## Context and Motivation\n## Problem Statement\n## Research Question, Motivation, and Approach\n## Thesis Contributions\n# Related Work\n## Machine Learning in Rare Cancer Prediction\n## Interpretable Machine Learning for Transparency\n## Multi-Stage and Cascade Learning Approaches\n# Methodology\n## Overview\n## Architecture and Technologies\n## Data Sources and Provenance\n## Dataset Size Summary\n## Exploratory Data Analysis (EDA)\n## Data Preprocessing\n## Robustness Evaluation Design\n## Classification Models\n## Cascade Learning for Biomarker Isolation\n## Interpretability and Feature Analysis\n## Ethical Considerations\n# Results and Discussion\n## Predictive Robustness of the GBM Gene Signature\n## PCA Analysis: Visual Evidence of Global Separability\n## SHAP Interpretability Confirms Biological Consistency\n## Biomarker Discovery Using SHAP and Feature Importance\n## Biological Validation of Consensus Biomarkers\n## Cascade Learning and Biomarker Discovery\n## Tab-to-Image Visualization\n## Discussion\n# Conclusion\n# Bibliography\n# Appendices","[{\"question\":\"What problem does the thesis address in rare cancer modeling?\",\"answer\":\"Rare cancers like GBM are difficult to model due to limited data, biological noise, and challenges isolating disease-specific molecular signatures. The thesis focuses on making predictions robust and extracting biomarkers despite extreme imbalance.\"},{\"question\":\"How does the work improve interpretability of the learned biomarkers?\",\"answer\":\"The framework uses SHAP-based interpretability to link selected genes to experimentally reported glioma biology. Cascade learning further isolates biomarkers by removing broad cancer pathways in stages.\"},{\"question\":\"What methods validate whether the model signal reflects meaningful biology?\",\"answer\":\"The thesis combines predictive robustness evaluations with biological validation against known glioma/GBM signatures. Tab2Image visualizations provide spatial confirmation of class separability, supporting trust in the learned signal.\"}]","Robust Prediction and Biomarker Discovery in Rare Cancers Using Interpretable Machine Learning - thesis | PDF",1785822743,229,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"robust-prediction-and-biomarker-discovery-in-rare-cancers-using-interpretable-machine-learning-thesis","",{"@graph":36,"@context":85},[37,54,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/research-report/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/robust-prediction-and-biomarker-discovery-in-rare-cancers-using-interpretable-machine-learning-thesis/124490/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":62,"encodingFormat":61,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-04",true,{"@type":65,"interactionType":66,"userInteractionCount":4},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What problem does the thesis address in rare cancer modeling?","Question",{"text":75,"@type":76},"Rare cancers like GBM are difficult to model due to limited data, biological noise, and challenges isolating disease-specific molecular signatures. The thesis focuses on making predictions robust and extracting biomarkers despite extreme imbalance.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"How does the work improve interpretability of the learned biomarkers?",{"text":80,"@type":76},"The framework uses SHAP-based interpretability to link selected genes to experimentally reported glioma biology. Cascade learning further isolates biomarkers by removing broad cancer pathways in stages.",{"name":82,"@type":73,"acceptedAnswer":83},"What methods validate whether the model signal reflects meaningful biology?",{"text":84,"@type":76},"The thesis combines predictive robustness evaluations with biological validation against known glioma/GBM signatures. Tab2Image visualizations provide spatial confirmation of class separability, supporting trust in the learned signal.","https://schema.org",{"og:url":52,"og:type":87,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":89,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,120,123,128,131,135],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":46,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":116,"doc_module":4,"doc_module_name":46,"category_name":117,"show_sort_weight":118,"slug":119},7,"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":121,"slug":122},30,"research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":106,"slug":138},19,"General","general"]