[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458514-105":59,"doc-detail-458514-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","rna-methylation-in-cancer-metabolism-from-mechanisms-to-therapeutic-opportunities","RNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities","","Cancer transformation depends heavily on metabolic reprogramming that supports rapid proliferation, migration, and metastasis. As a key post-transcriptional epigenetic layer, RNA methylation modifications dynamically and reversibly shape RNA processing and metabolism, thereby altering expression of specific molecules and downstream biological processes. This review summarizes major RNA methylation types in cancer and clarifies how RNA modifications drive metabolic reprogramming across glucose, lipid, amino acid, and mitochondrial metabolism. It further discusses clinical relevance for mechanism-based metabolic targeted therapy and immunotherapy, linking molecular insights to therapeutic application.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rna-methylation-in-cancer-metabolism-from-mechanisms-to-therapeutic-opportunities/458514/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rna-methylation-in-cancer-metabolism-from-mechanisms-to-therapeutic-opportunities/458514.png","ImageObject",300,407,{"name":92,"@type":93},"Cipher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does metabolic reprogramming support cancer progression?","Question",{"text":112,"@type":113},"Cancer cells rewire metabolic circuits to generate energy and biosynthetic precursors needed for rapid growth and improved survival under stress.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does RNA methylation play in cancer metabolism?",{"text":117,"@type":113},"RNA methylation acts as a reversible post-transcriptional epigenetic mechanism that regulates RNA processing and metabolism, influencing metabolic enzymes and signaling pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"Which metabolic areas are covered when explaining RNA modification-driven metabolic reprogramming?",{"text":121,"@type":113},"The review focuses on glucose, lipid, amino acid, and mitochondrial metabolism, describing how RNA modifications affect each.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458514,1791076312,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687208528416,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Ivyspring  \nInternational Publisher  \nInternationalJournal of Biological Sciences  \n2026; 22(2): 920-950. doi: 10.7150/ijbs.124177  \nReview  \nRNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities  \nZeyu Wu1\\#, Yuncan Xing1\\#, Shiwen Mei1, Tixian Xiao1, Fangze Wei2, Qian Liu1􀀍  \n1. Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.  \n2. Department of Clinical Laboratory, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.  \n\\# These authors have made equal contributions to the study.  \n􀀍 Corresponding authors: Qian Liu, tel.: +8617860628929, email: [liuqian@cicams.ac.cn](liuqian@cicams.ac.cn).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [https://ivyspring.com/terms](https://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2025.08.23; Accepted: 2025.12.01; Published: 2026.01.01  \nAbstract  \nOne of the most important changes in the transformation of normal cells into tumor cells is metabolism. In order to satisfy the more active proliferation, migration and metastasis of cancer cells, abnormal changes occur in various pathways and molecules involved in metabolism, which eventually lead to metabolic reprogramming of tumor cells. This process involves the uptake of nutrients and changes in major metabolic forms. As an important part of post-transcriptional epigenetics, RNA methylation modifications can regulate RNA processing and metabolism, while dynamically and reversibly influencing the expression of specific molecules, thereby ultimately affecting diverse biological processes and cellular phenotypes. In this review, various types of RNA methylation modifications involved in cancer are summarized. Subsequently, we systematically elucidate the mechanism of RNA modification for metabolic reprogramming in cancer, including glucose, lipid, amino acid and mitochondrial metabolism. Most importantly, we discuss in depth the clinical significance of RNA modification in metabolic targeted therapy and immunotherapy from mechanism to therapeutic application.  \nKeywords: RNA methylation, cancer, metabolism, clinical application  \n1. Introduction  \nRNA methylation modification first came into human view in the 1950s, when the first structurally modified nucleoside pseudouridine was labeled[1] . Over the following decades, more than 150 different classes of RNA modifications have been validated and discovered on cellular RNA[2] . However, researches on RNA modifications in disease have progressed slowly during this period. The past decade has seen a renaissance in RNA modification research, attracting increasing scientific attention [3]. In particular, in 2023, nucleoside base modification’s contribution to the development of an mRNA vaccine against COVID-19 earned it a Nobel Prize that year, greatly inspiring biologists working on RNA-based therapies[4] . The landscape of post-transcriptional regulation is profoundly shaped by RNA modifications, among which RNA methylation stands out as one of the most  \nabundant, reversible, and well-studied epigenetic mechanisms.  \nCancer is one of the greatest threats to global public health. Despite significant progress in cancer detection and management, there are still tens of millions of new cancer cases and nearly half of cancer-related deaths occurring each year[5, 6] . A defining feature of cancer is metabolic reprogramming, an adaptive mechanism whereby cancer cells rewire their metabolic circuits to support rapid growth and enhance survival under stressful conditions.","cbCaiu2BPFw9IeuS","https://ap.wps.com/l/cbCaiu2BPFw9IeuS","pdf",5484104,31,"English","# Introduction\n# The Writer, Reader, and Eraser Enzymes of RNA Methylation\n## m⁶A: The most prevalent RNA methylation modification","[{\"question\":\"How does metabolic reprogramming support cancer progression?\",\"answer\":\"Cancer cells rewire metabolic circuits to generate energy and biosynthetic precursors needed for rapid growth and improved survival under stress.\"},{\"question\":\"What role does RNA methylation play in cancer metabolism?\",\"answer\":\"RNA methylation acts as a reversible post-transcriptional epigenetic mechanism that regulates RNA processing and metabolism, influencing metabolic enzymes and signaling pathways.\"},{\"question\":\"Which metabolic areas are covered when explaining RNA modification-driven metabolic reprogramming?\",\"answer\":\"The review focuses on glucose, lipid, amino acid, and mitochondrial metabolism, describing how RNA modifications affect each.\"}]","RNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities | PDF",1790753554,78]