[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381365-105":59,"doc-detail-381365-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","rna-based-liquid-biopsy-in-head-and-neck-cancer","RNA-Based Liquid Biopsy in Head and Neck Cancer","","Head and neck cancer (HNC) is a heterogeneous group of malignancies associated with high morbidity and mortality, making timely detection and follow-up essential. Liquid biopsy provides a non-invasive diagnostic route with growing clinical relevance. This review analyzes RNA-based liquid biopsy for HNC, covering multiple RNA species—mRNA, miRNA, lncRNA, snRNA, snoRNA, circRNA, and piRNA—as candidate biomarkers. It summarizes their roles in diagnosis, metastasis, treatment resistance to radiotherapy and chemotherapy, and prognosis, highlighting potential for early detection and personalized care.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rna-based-liquid-biopsy-in-head-and-neck-cancer/381365/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rna-based-liquid-biopsy-in-head-and-neck-cancer/381365.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early detection and monitoring of head and neck cancer important?","Question",{"text":112,"@type":113},"Early detection and ongoing monitoring improve patient outcomes because HNC has substantial morbidity and mortality and generally poor prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which RNA types are reviewed as biomarkers for RNA-based liquid biopsy in HNC?",{"text":117,"@type":113},"The review discusses messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA), small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), circular RNA (circRNA), and PIWI-interacting RNA (piRNA).",{"name":119,"@type":110,"acceptedAnswer":120},"How can RNA-based liquid biopsy contribute beyond diagnosis?",{"text":121,"@type":113},"RNA-based liquid biopsy is presented as promising for prognosis assessment and supporting personalized treatment decisions, including insights into metastasis and resistance to radio and chemotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381365,1790450548,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","cells  \nReview  \nRNA-Based Liquid Biopsy in Head and Neck Cancer Jacek Kabzinski , Aleksandra Kucharska-Lusina and Ireneusz Majsterek *  \nCitation: Kabzinski, J.;  \nKucharska-Lusina, A.; Majsterek, I. RNA-Based Liquid Biopsy in Head and Neck Cancer. Cells 2023, 12, 1916 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cells12141916  \nAcademic Editors: Julia Bar, Nina Zidar and Piotr Cierpikowski  \nReceived: 26 June 2023  \nRevised: 17 July 2023  \nAccepted: 21 July 2023  \nPublished: 23 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, MolecoLAB A6, Mazowiecka 5,  \n92-215 Lodz, Poland; [jacek.kabzinski@umed.pl](jacek.kabzinski@umed.pl) (J.K.); [ola_kucharska@wp.pl](ola_kucharska@wp.pl) (A.K.-L.)  \n* Correspondence: [ireneusz.majsterek@umed.pl](ireneusz.majsterek@umed.pl); Tel.: +48-42-6393306  \nAbstract: Head and neck cancer (HNC) is a prevalent and diverse group of malignancies with substantial morbidity and mortality rates. Early detection and monitoring of HNC are crucial for improving patient outcomes. Liquid biopsy, a non-invasive diagnostic approach, has emerged as a promising tool for cancer detection and monitoring. In this article, we review the application of RNAbased liquid biopsy in HNC. Various types of RNA, including messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA), small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), circular RNA (circRNA) and PIWI-interacting RNA (piRNA), are explored as potential biomarkers in HNC liquid-based diagnostics. The roles of RNAs in HNC diagnosis, metastasis, tumor resistance to radio and chemotherapy, and overall prognosis are discussed. RNA-based liquid biopsy holds great promise for the early detection, prognosis, and personalized treatment of HNC. Further research and validation are necessary to translate these findings into clinical practice and improve patient outcomes.  \nKeywords: cancer; HNC; liquid biopsy; mRNA; miRNA; circRNA; lncRNA; piRNA; snRNA; snoRNA  \n1. Head and Neck Cancer  \nCancer is one of the greatest challenges of modern medicine. Despite the huge funds allocated to research, prevention and treatment, both the number of cases and mortality increases every year [1] . Head and neck cancers (HNC) are part of this trend and rank seventh in the world in terms of new cases (660,000) and deaths (325,000) per year [2,3] . HNC is a wide group of diseases, and while there is a lack of consensus on the definitions of `head and neck cancer' terminology, according to GLOBOCAN they include primarily: lip cancer, oral cavity cancer, larynx, nasopharynx, oropharynx and hypopharynx cancers [1] . A detailed breakdown of HNC by location is presented in Figure 1.  \nThe increase in morbidity and mortality is driven mainly by oropharyngeal cancer, and the main causative factors are aging and growth of the population as well as changes in the prevalence and distribution of the main environmental risk factors such as smoking, alcohol consumption (and in particular both factors accounting for 72% of cases when used in combination [4]) and human papillomavirus (HPV) infection (especially HPV type 16, a major risk factor for oropharyngeal cancer [5]) [3,6] . Moreover, risk factors may interact with each other, leading to a cumulative increase in risk [7] . Other factors such as diet [8,9], genetics [10] and oral hygiene [11,12] are considered to have a minor impact on risk modulation.  \nIt is estimated that the annual increase in the incidence of HNC may reach 30% per year until 2030, and the decreasing number of HPV-unrelated cases in Europe","cbCaihLNyQOoRS9G","https://ap.wps.com/l/cbCaihLNyQOoRS9G","pdf",1019398,27,"English","# Head and Neck Cancer\n## Epidemiology and risk factors\n## Diagnostic challenges and emerging methods\n## Survival and prognosis","[{\"question\":\"Why is early detection and monitoring of head and neck cancer important?\",\"answer\":\"Early detection and ongoing monitoring improve patient outcomes because HNC has substantial morbidity and mortality and generally poor prognosis.\"},{\"question\":\"Which RNA types are reviewed as biomarkers for RNA-based liquid biopsy in HNC?\",\"answer\":\"The review discusses messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA), small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), circular RNA (circRNA), and PIWI-interacting RNA (piRNA).\"},{\"question\":\"How can RNA-based liquid biopsy contribute beyond diagnosis?\",\"answer\":\"RNA-based liquid biopsy is presented as promising for prognosis assessment and supporting personalized treatment decisions, including insights into metastasis and resistance to radio and chemotherapy.\"}]","RNA-Based Liquid Biopsy in Head and Neck Cancer | PDF",1790245029,68]