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Data were obtained for 7,197 patients diagnosed between 1980 and 2022 from the Finnish Cancer Registry. Standardized incidence ratios (SIR) were calculated versus the general population. Follow-up averaged 2.8 years and the median was 10.5 months. SPC risk increased after 15–20 years, with histology-specific patterns in digestive, mouth/pharynx, and respiratory cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/risk-of-second-primary-cancer-among-patients-with-cardio-esophageal-cancer-in-finland-a-nationwide-population-based-study/328436/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/risk-of-second-primary-cancer-among-patients-with-cardio-esophageal-cancer-in-finland-a-nationwide-population-based-study/328436.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-14","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study purpose regarding second primary cancer risk?","Question",{"text":112,"@type":113},"To assess the histology-specific risk of second primary cancer after an initial diagnosis of first primary esophageal carcinoma or gastric cardia carcinoma in Finland.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were second primary cancer risks measured in this research?",{"text":117,"@type":113},"The study used standardized incidence ratios (SIR) comparing SPC occurrence among EC/GCC patients with the cancer risk in the general population.",{"name":119,"@type":110,"acceptedAnswer":120},"When did the increased SPC risk become most apparent?",{"text":121,"@type":113},"An increased SIR was observed among EC/GCC patients after 15–20 years of follow-up.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328436,1790579241,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Clinical Epidemiology Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article ORIGINAL RESEARCH  \nRisk of Second Primary Cancer Among Patients with Cardio-Esophageal Cancer in Finland: A Nationwide Population-Based Study  \nRayan Nikkilä 1–4 , Elli Hirvonen 1 , Janne Pitkäniemi 1 , 5 , 6 , Jari V Räsänen 7 , Nea K Malila 1 , Antti Mäkitie 2 , 3 , 8  \n1Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; 2Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 3Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; 4Päijät-Häme Joint Authority for Health and Wellbeing, Department of Oral and Maxillofacial Surgery, Lahti Central Hospital, Lahti, 15850, Finland; 5Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; 6Department of Public Health, University of Helsinki, Helsinki, Finland; 7Department of General Thoracic and Oesophageal Surgery, Heart and Lung Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 8Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden  \nCorrespondence: Antti Mäkitie, Helsinki University Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, P.O.Box 263, FI-00029 HUS, Helsinki, Finland, Tel +358-50-428 6847, [Email antti.makitie@helsinki.fi](Email antti.makitie@helsinki.fi)  \n\n| Purpose: The occurrence of a second primary cancer (SPC) after primary esophageal carcinoma (EC) or gastric cardia carcinoma (GCC) is well acknowledged. However, previous research on the risk of SPC among these patients has been predominantly conducted in Asian countries. Yet, notable population-dependent variation in histological types and risk profiles exists. This register-based study assesses the histology-specific risk of SPC among individuals initially diagnosed with a first primary EC or GCC.\u003Cbr>Patients and Methods: We obtained data on 7197 patients diagnosed with EC/GCC in Finland between 1980 and 2022 from the Finnish Cancer Registry. Standardized incidence ratios (SIR) of SPC were subsequently calculated relatively to the cancer risk of the general population.\u003Cbr>Results: The average and median follow-up times were 2.8 years and 10.5 months. Adenocarcinomas and squamous cell carcinomas comprised 57.8%(n = 4165) and 36.6%(n = 2631) of all cases, respectively. An increased SIR was noted among EC/GCC patients after 15–20 years of follow-up (SIR 1.49, 95% CI: 1.01–2.11) . Among adenocarcinoma patients, an increased SIR for SPCs of the digestive organs was seen in the 40–54-year-old group (SIR 9.86, 95% CI: 3.62–21.45) . Squamous cell carcinoma patients displayed increased SIRs for cancer of the mouth/pharynx (SIR 3.20, 95% CI: 1.17–6.95) and respiratory organs (1.77, 1.07–2.76) . Conclusion: Healthcare professionals should be aware of the increased risk of SPCs occurring in the mouth/pharynx, respiratory and digestive organs in survivors of EC/GCC. Patients should be advised about this risk and remain alert for symptoms, even beyond the standard 5-year follow-up period.\u003Cbr>Keywords: esophageal squamous cell carcinoma, adenocarcinoma, gastric cardia carcinoma, tumor, second primary cancer |\n| --- |\n| Introduction\u003Cbr>According to the Global Cancer Observatory database ([www.gco.iarc.fr](www.gco.iarc.fr)), esophageal carcinoma (EC) ranks as the eighth most common cancer worldwide with well over half a million new cases diagnosed annually worldwide. Moreover, the number of new cases is anticipated to increase by approximately 40% in the next decade. However, incidence rates vary significantly worldwide. Namely, around 80% of new EC cases occur in Asia, with China and Bangladesh having the highest country-specific age-sta","cbCaillU5I4lQhvo","https://ap.wps.com/l/cbCaillU5I4lQhvo","pdf",8141721,11,"English","# Purpose\n# Patients and Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What was the study purpose regarding second primary cancer risk?\",\"answer\":\"To assess the histology-specific risk of second primary cancer after an initial diagnosis of first primary esophageal carcinoma or gastric cardia carcinoma in Finland.\"},{\"question\":\"How were second primary cancer risks measured in this research?\",\"answer\":\"The study used standardized incidence ratios (SIR) comparing SPC occurrence among EC/GCC patients with the cancer risk in the general population.\"},{\"question\":\"When did the increased SPC risk become most apparent?\",\"answer\":\"An increased SIR was observed among EC/GCC patients after 15–20 years of follow-up.\"}]","Risk of Second Primary Cancer Among Patients with Cardio-Esophageal Cancer in Finland - A Nationwide Population-Based Study | PDF",1789979751,28]