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Cumulative incidences and hazard rates were analyzed among 443 FAP patients with gastric adenoma and gastric cancer data, focusing on age-specific risk patterns and associations with colonic phenotype.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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was the study’s main objective regarding FAP and gastric lesions?","Question",{"text":63,"@type":64},"To clarify how the incidence risk of developing gastric adenoma or gastric cancer changes during patients’ lifespans in familial adenomatous polyposis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the risk evaluated in the study?",{"text":68,"@type":64},"By analyzing cumulative incidences and hazard rates, with hazard-function approaches used to describe how risk changes over time.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about age-related risk?",{"text":72,"@type":64},"Cumulative incidence in 50-year-old patients was 22.8% for gastric adenoma and 7.6% for gastric cancer, with the hazard rate for adenoma peaking around 65 years and gastric cancer risk accelerating from about age 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\n[https://doi.org/10.1007/s00535-023-02074-8](https://doi.org/10.1007/s00535-023-02074-8)  \nORIGINAL ARTICLE—ALIMENTARY TRACT  \nRisk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study  \nKazuhito Sasaki1,2 · Kazushige Kawai1,3 · Hiroaki Nozawa1 · Soichiro Ishihara1 · Hideyuki Ishida2,4 · Keiichiro Ishibashi4 · Yoshiko Mori4 · Satoki Shichijo2,5 · Yasuhiro Tani5 · Yoji Takeuchi6 · Akiko Chino2,7 · Misato Takao3 · Kenji Fujiyoshi2,8 · Takaaki Matsubara2,9 · Yasuyuki Miyakura2,10 · Fumitaka Taniguchi11 · Tatsuro Yamaguchi2,12 · Kohji Tanakaya2,11 · Naohiro Tomita2,13 · Yoichi Ajioka2,14  \nReceived: 23 September 2023 / Accepted: 26 December 2023 / Published online: 23 January 2024  \n© The Author(s) 2024  \nAbstract  \nBackground Patients with familial adenomatous polyposis (FAP) have an increased risk of developing gastric neoplasms. However, the clinical course of FAP with these gastric lesions has not yet been fully clarified. The present study aimed to clarify the changes in the incidence risk of developing gastric adenoma or gastric cancer during the lifespan of patients with FAP.  \nMethods Four hundred forty-three patients with data regarding gastric adenoma and gastric cancer retrospectively  \nSupplementary Information The online version contains supplementary material available at [https://doi.org/10.1007/](https://doi.org/10.1007/)[ ](https://doi.org/10.1007/)s00535-023-02074-8.  \n* Kazuhito Sasaki [sasakik-tky@umin.ac.jp](sasakik-tky@umin.ac.jp)  \n1 Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan  \n2 The Committee of Hereditary Colorectal Cancer, Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan  \n3 Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan  \n4 Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan  \n5 Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan  \n6 Department of Genetic Oncology, Division of Hereditary Tumors and Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan  \n7 Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan  \nregistered in a nationwide Japanese multicenter study were enrolled. The cumulative incidences and hazard rates (HRs) of gastric neoplasms were evaluated.  \nResults The cumulative incidence rates in 50-year-old patients with FAP were 22.8% for gastric adenoma and 7.6% for gastric cancer, respectively. No significant association was found between gastric neoplasms and the colonic phenotype. The peak age for the HR of gastric adenoma was 65 years, with the highest HR (0.043) . Regarding the incidence of gastric cancer, the HR increased moderately up to the age of 40 years, but the increase accelerated from the age of 50 years (HR = 0.0067) .  \nConclusion Careful surveillance of the upper gastrointestinal tract in elderly patients with FAP, such as shortening  \n8 Department of Surgery, Kurume University School of Medicine, Kurume, Japan  \n9 Department of Surgery, Hyogo College of Medicine, Hyogo, Japan  \n10 Department of Surgery, Saitama Medical Center Jichi Medical University, Saitama, Japan  \n11 Department of Surgery, National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Japan  \n12 Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan  \n13 Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Japan  \n14 Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan  \nthe interval of follow-up according to age, may be helpful for early diagnosis of gastric cancer.  \nKeywords Fa","cbCaiepIfafN60tJ","https://ap.wps.com/l/cbCaiepIfafN60tJ","pdf",1219383,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the study’s main objective regarding FAP and gastric lesions?\",\"answer\":\"To clarify how the incidence risk of developing gastric adenoma or gastric cancer changes during patients’ lifespans in familial adenomatous polyposis.\"},{\"question\":\"How was the risk evaluated in the study?\",\"answer\":\"By analyzing cumulative incidences and hazard rates, with hazard-function approaches used to describe how risk changes over time.\"},{\"question\":\"What did the results show about age-related risk?\",\"answer\":\"Cumulative incidence in 50-year-old patients was 22.8% for gastric adenoma and 7.6% for gastric cancer, with the hazard rate for adenoma peaking around 65 years and gastric cancer risk accelerating from about age 50.\"}]","Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan - a nationwide multicenter study | PDF",1789995615]