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Neonatal phototherapy was linked to higher risk of hematopoietic cancers and solid tumors, though evidence quality remained limited by bias and residual confounding.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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question does the study address about neonatal phototherapy?","Question",{"text":63,"@type":64},"It evaluates whether exposure to neonatal phototherapy is associated with increased rates of childhood neoplasms and cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which study types were included in the review?",{"text":68,"@type":64},"Observational human studies with control groups were included regardless of design, including cohort and case-control studies.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings on cancer risk?",{"text":72,"@type":64},"Children with a history of neonatal phototherapy had increased risk of hematopoietic cancer and solid tumors, with odds ratios reported higher in both cohort and case-control evidence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},329264,1790013177,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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related to neonatal phototherapya systematic review and meta-analysis  \nIlari Kuitunen 1,2 ✉ , Atte Nikkilä3,4, Panu Kiviranta 1,2,5, Johanna Jääskeläinen 1 and Anssi Auvinen6  \n© The Author(s) 2024  \nCONTEXT: Observational studies have shown conflicting results as to whether exposure to neonatal phototherapy is associated with increased rates of childhood cancer.  \nOBJECTIVE: To describe the rates of childhood neoplasms and cancer after neonatal phototherapy.  \nDATA SOURCES: The CENTRAL, PubMed, Scopus, and Web of Science databases.  \nSTUDY SELECTION: Observational studies regardless of design were included.  \nDATA EXTRACTION: The data were extracted by one author and validated by another. The risk-of-bias assessment was performed using the ROBINS-E and Joanna Briggs Institute critical appraisal tools.  \nRESULTS: Six cohort and 10 case-control studies were included. The overall risk of bias was high in seven and low in nine studies. In cohort studies, the odds ratio (OR) was increased for hematopoietic cancer (1.44; confidence interval [CI]: 1.16–1.80) and solid  \ntumors (OR: 1.18; CI: 1.00–1.40) . In case-control studies, the OR was 1.63 (CI: 0.99–2.67) for hematopoietic cancers and 1.18 (CI: 1.04–1.34) for solid tumors.  \nCONCLUSIONS: Children with a history of neonatal phototherapy had increased risk of hematopoietic cancer and solid tumors. The evidence quality was limited due to the high risk of bias and potential residual confounding.  \nPediatric Research (2024) 96:1131–1140; [https://doi.org/10.1038/s41390-024-03191-7](https://doi.org/10.1038/s41390-024-03191-7)  \nIMPACT STATEMENT:  \n● Exposure to neonatal phototherapy increased later risk of hematopoietic cancer and solid tumors.  \n● This is the most comprehensive study on the association between phototherapy and cancer, but the evidence quality was limited due risk of bias and residual confounding.  \n● Future large scale well conducted studies are still needed to better estimate the association and.  \nINTRODUCTION  \nNeonatal jaundice is a common condition during the first month of life, as approximately 70% of neonates have some level of jaundice, and 5% to 10% require phototherapy for treatment ofunconjugated hyperbilirubinemia.1–3 Phototherapy is commonly used to decrease bilirubin levels in order to avoid the neurotoxic effects of high bilirubin levels. Some of the known risk factors for unconjugated hyperbilirubinemia requiring phototherapy are maternal red blood cell antibodies, prematurity, birth injuries, hereditary factors (ethnicity and a history of phototherapy in older siblings), and maternal obesity.3–5  \nPhototherapy has been associated with some short-term adverse events, such as rash, dehydration, and difficulties with breastfeeding,6,7 as well as with long-term risks, such as allergies and seizure disorders.8–10 Phototherapy has been suggested to cause DNA damage and promote reactive oxygen species and proinflammatory cytokines, which could lead to an increased cancer risk.11 In addition, phototherapy has been associated with increased incidence of café-  \nau-lait macules in children but not with melanocytic nevi.12, 13 Previous studies have shown conflicting results regarding the possible increased incidence of childhood cancers following neonatal phototherapy. In some cohort studies, children exposed to phototherapy had an increased risk of all childhood cancers,14, 15 whereas no such excess was reported in other studies.16, 17 It has also been speculated that there may be an association between hyperbilirubinemia and malignancies. Therefore, the association between phototherapy may be due to higher bilirubin levels or other maternal/neonatal factors that increase the risk for both hyperbilirubinemia and neoplasms. As phototherapy is an effective and frequently used therapy for neonatal unconjugated hyperbilirubinemia,18 evidence summaries on possible long-term ","cbCainRfyvQqF63V","https://ap.wps.com/l/cbCainRfyvQqF63V","pdf",1180553,"English","# Context and objective\n# Data sources and study selection\n# Data extraction and risk-of-bias assessment\n# Results\n## Cohort studies\n## Case-control studies\n# Conclusions\n# Introduction\n# Methods\n## Search process\n## Inclusion criteria","[{\"question\":\"What question does the study address about neonatal phototherapy?\",\"answer\":\"It evaluates whether exposure to neonatal phototherapy is associated with increased rates of childhood neoplasms and cancer.\"},{\"question\":\"Which study types were included in the review?\",\"answer\":\"Observational human studies with control groups were included regardless of design, including cohort and case-control studies.\"},{\"question\":\"What were the main findings on cancer risk?\",\"answer\":\"Children with a history of neonatal phototherapy had increased risk of hematopoietic cancer and solid tumors, with odds ratios reported higher in both cohort and case-control evidence.\"}]","Risk of Childhood Neoplasms Related to Neonatal Phototherapy - A Systematic Review and Meta-Analysis | PDF",1789983340,25]