[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330602-105":59,"doc-detail-330602-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","risk-of-cancer-in-patients-with-bile-acid-diarrhoea-a-danish-nationwide-matched-cohort-study","Risk of cancer in patients with bile acid diarrhoea - a Danish nationwide matched cohort study","","Bile acid diarrhoea is a common cause of chronic diarrhoea, with potentially carcinogenic bile acids raising a theoretical concern for colorectal cancer, while long-term outcomes remain unclear. A Danish nationwide matched cohort study identified adult patients diagnosed between 2003 and 2020 using a SeHCAT procedure followed by sequestrant prescriptions, then compared overall and site-specific cancer incidence versus matched controls. Overall cancer risk increased (HR 1.32), with elevated risk in haematological, skin, and male genital cancers, while colorectal cancer risk was not increased (HR 0.73).",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/risk-of-cancer-in-patients-with-bile-acid-diarrhoea-a-danish-nationwide-matched-cohort-study/330602/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/risk-of-cancer-in-patients-with-bile-acid-diarrhoea-a-danish-nationwide-matched-cohort-study/330602.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the study?","Question",{"text":112,"@type":113},"To investigate overall and site-specific cancer risk in patients with bile acid diarrhoea.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients with bile acid diarrhoea identified?",{"text":117,"@type":113},"Adults were identified using Danish nationwide registries from 2003 to 2020 using a gold-standard SeHCAT diagnostic procedure, followed within 6 months by sequestrant prescription.",{"name":119,"@type":110,"acceptedAnswer":120},"Did bile acid diarrhoea increase the risk of colorectal cancer?",{"text":121,"@type":113},"No. The study did not detect an increased risk of colorectal cancer (HR 0.73, 95% CI 0.34 to 1.63).",{"name":123,"@type":110,"acceptedAnswer":124},"Which cancer sites showed increased risk?",{"text":125,"@type":113},"The risk was increased in three of 10 cancer groups: haematological cancers (HR 2.41), skin (HR 1.33), and male genital cancers (HR 1.85).","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},330602,1790099043,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":46},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Epidemiology  \nTo cite: Nyboe Andersen N, Wildt S, Iversen AT, et al. Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study. BMJ Open Gastroenterol 2024;11:e001340 . doi:10 . 1136/ bmjgast-2023-001340  \nReceived 4 January 2024 Accepted 13 April 2024  \n© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.  \n1Department of Gastroenterology, Zealand University Hospital Koge, Koge, Denmark  \n2Department of Gastroenterology and Hepatology, Hvidovre Hospital, Hvidovre, Denmark  \n3Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Copenhagen, Denmark  \nCorrespondence to  \nDr Nynne Nyboe Andersen; [nynne@nyboeandersen.com](nynne@nyboeandersen.com)  \nRisk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study  \nNynne Nyboe Andersen  ,1 Signe Wildt,2 Aske Thorn Iversen,3 Gry Poulsen,3 Tine Jess  ,3 Lars Kristian Munck,1 Christian Borup1  \nABSTRACT  \nObjective Bile acid diarrhoea is a common cause of chronic diarrhoea. Increased levels of potentially carcinogenic bile acids in faeces, theoretically, may increase the risk of colorectal cancer in particular, but the long-term disease course is unknown. We aimed to investigate the overall and site-specific cancer risk in bile acid diarrhoea.  \nDesign Adult patients with bile acid diarrhoea were identified using nationwide Danish registries from 2003 to 2020 by a diagnostic gold-standard 75-selenium tauroselcholic acid procedure followed within 6 months by sequestrant prescription. The risk of overall and  \nsite-specific cancers in cases with bile acid diarrhoea was compared with sex, age and comorbidity-adjusted matched controls. A competing risk model estimated cumulative incidence functions and cause-specific HRs. Results We identified 2260 patients with bile acid diarrhoea with a mean follow-up of 5.5 years (SD 4 .2) . The overall cancer risk was increased by an HR of 1.32 (95% CI 1.12 to 1 .54) . The risk of site-specific cancer was increased in 3 of 10 cancer groups: haematological, HR 2.41 (1 .36 to 4 .02); skin, HR 1.33 (1 .01 to 1.71); and male genital cancers, HR 1.85 (1 .11 to 2 .92) . No increased risk of colorectal cancer was detected in patients with bile acid diarrhoea, HR 0.73 (0 .34 to 1 .63) .  \nConclusions Bile acid diarrhoea was associated  \nwith an increased overall risk of cancer, especially haematological cancers, but the risk of colorectal cancer was not increased. The lack of a diagnostic code for bile acid diarrhoea and potential residual confounding are limitations, and the findings should be replicated in other cohorts.  \nINTRODUCTION  \nBile acid diarrhoea (BAD) is found in an estimated 1% of the general population.1 Increased concentrations of dihydroxy bile acids in the colon trigger peristalsis and watery secretion, leading to watery diarrhoea.2–4 This condition may be primary, due to hepatic overproduction of bile acids exceeding the small bowel capacity to reabsorb bile acids, or secondary to dysfunction or resection of the terminal ileum.3 5 Additionally, changes in the bile acid profile from  \nWHAT IS ALREADY KNOWN ON THIS TOPIC  \n\n| ⇒ One-third of patients diagnosed with diarrhoea-type irritable bowel syndrome actually have bile acid diarrhoea.\u003Cbr>⇒ Levels of potentially carcinogenic bile acids are elevated in faeces.\u003Cbr>⇒ This may, in theory, increase the risk, particularly of colorectal cancer.\u003Cbr>⇒ The long-term risk of cancer is unknown.\u003Cbr>WHAT THIS STUDY ADDS |\n| --- |\n| ⇒ Patients with bile acid diarrhoea had a 32% increased risk of overall cancer driven by haematological, skin, and male genital cancers.\u003Cbr>⇒ The risk of colorectal cancer was not increased.\u003Cbr>HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY |\n\n⇒ The observed increased risk of three site-specific cancers needs replication.  \n⇒ ","cbCaik2DNNfz02xB","https://ap.wps.com/l/cbCaik2DNNfz02xB","pdf",617590,"English","# Abstract\n## Objective\n## Design\n## Results\n## Conclusions\n# Introduction\n## Epidemiology and pathophysiology of BAD\n## Rationale and prior evidence\n# Methods\n## Study population\n## Exposure information","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To investigate overall and site-specific cancer risk in patients with bile acid diarrhoea.\"},{\"question\":\"How were patients with bile acid diarrhoea identified?\",\"answer\":\"Adults were identified using Danish nationwide registries from 2003 to 2020 using a gold-standard SeHCAT diagnostic procedure, followed within 6 months by sequestrant prescription.\"},{\"question\":\"Did bile acid diarrhoea increase the risk of colorectal cancer?\",\"answer\":\"No. The study did not detect an increased risk of colorectal cancer (HR 0.73, 95% CI 0.34 to 1.63).\"},{\"question\":\"Which cancer sites showed increased risk?\",\"answer\":\"The risk was increased in three of 10 cancer groups: haematological cancers (HR 2.41), skin (HR 1.33), and male genital cancers (HR 1.85).\"}]","Risk of cancer in patients with bile acid diarrhoea - a Danish nationwide matched cohort study | PDF",1789989505]