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It is published as open access in Frontiers in Immunology, with multiple contributing authors and affiliations across medical centers. 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ACCESS  \nEDITED BY  \nOzgur Kasapcopur,  \nIstanbul University-Cerrahpasa, Türkiye  \nREVIEWED BY Sezgin Sahin,  \nIstanbul University-Cerrahpasa, Türkiye Oya Koker,  \nIstanbul University, Türkiye  \n*CORRESPONDENCE Luca Cantarini  \n [cantariniluca@hotmail.com](cantariniluca@hotmail.com)  \n†These authors have contributed equally to this work  \nRECEIVED 08 March 2024  \nACCEPTED 22 April 2024  \nPUBLISHED 10 May 2024  \nCITATION  \nVitale A, Caggiano V, Tufan A, Ragab G, Batu ED, Portincasa P, Aragona E, Sota J, Conti G, De Paulis A, Rigante D, Olivieri AN, ahin A, La Torre F, Lopalco G, Cattalini M, Maggio MC, Insalaco A, Sfikakis PP, Verrecchia E, Yildirim D, Kucuk H, Kardas RC, Laymouna AH, Ghanema M, Saad MA,  \nSener S, Ercan Emreol H, Ozen S, Jaber N, Khalil M, Di Ciaula A, Gaggiano C, Malizia G, Affronti A, Patroniti S, Romeo M, Sbalchiero J, Della Casa F, Mormile I, Silvaroli S,  \nGicchino MF, C¸elik NC¸, Tarsia M, Karamanakos A, Hern´andez-Rodrguez J, Parronchi P, Opris-Belinski D, Barone P, Recke A, Costi S, Sfriso P, Giardini HAM, Gentileschi S, Wiesik-Szewczyk E, Vasi I, Loconte R, Jahnz-Ro´z˙yk K, Martn-Nares E, Torres-Ruiz J, Cauli A, Conforti A, Emmi G, Li Gobbi F, Biasi GR, Terribili R, Ruscitti P, Del Giudice E, Tharwat S, Brucato AL, Ogunjimi B, Hinojosa-Azaola A, Balistreri A, Fabiani C, Frediani B and Cantarini L (2024) Risk for cancer development in familial Mediterranean fever and associated predisposing factors: anambidirectional cohort study from the international AIDA Network registries.  \nFront. Immunol. 15:1397890 .  \ndoi: 10.3389/fimmu.2024.1397890  \nRisk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries  \nAntonio Vitale 1,2†, Valeria Caggiano 1,2†, Abdurrahman Tufan 3, Gaafar Ragab 4,5, Ezgi Deniz Batu 6, Piero Portincasa 7, Emma Aragona 8, Jurgen Sota 1,2, Giovanni Conti 9,  \nAmato De Paulis 10,11, Donato Rigante 12,13, Alma Nunzia Olivieri 14, Ali S¸ahin 15, Francesco La Torre 16, Giuseppe Lopalco 17,  \nMarco Cattalini 18, Maria Cristina Maggio 19, Antonella Insalaco 20, Petros P. Sfikakis21, Elena Verrecchia 13,22, Derya Yildirim 3, Hamit Kucuk 3, Riza Can Kardas 3, Ahmed Hatem Laymouna 4, Mahmoud Ghanema 4, Moustafa Ali Saad 4, Seher Sener 6, Hulya Ercan Emreol 6, Seza Ozen 6, Nour Jaber 7,  \nMohamad Khalil 7, Agostino Di Ciaula 7, Carla Gaggiano 1,2, Giuseppe Malizia 8, Andrea Affronti 8, Serena Patroniti 9,  \nMeri Romeo 9, Jessica Sbalchiero 1,2, Francesca Della Casa 10, Ilaria Mormile 10, Sara Silvaroli 23, Maria Francesca Gicchino 14, Nee C¸abuk C¸elik 15, Maria Tarsia 2,24, Anastasios Karamanakos 25, Jos´e Hern´andez-Rodr ´ıguez 26, Paola Parronchi 27,  \nDaniela Opris-Belinski 28, Patrizia Barone 29, Andreas Recke 30,31, Stefania Costi 32, Paolo Sfriso 33, Henrique A. Mayrink Giardini 34, Stefano Gentileschi 1,2, Ewa Wiesik-Szewczyk 35, Ibrahim Vasi 3, Roberta Loconte 16, Karina Jahnz-Ro´ ˙zyk 35,  \nEduardo Mart ´ın-Nares 36, Jiram Torres-Ruiz 36, Alberto Cauli 37, Alessandro Conforti 38, Giacomo Emmi 39,40,  \nFrancesca Li Gobbi 41, Giovanni Rosario Biasi 1,2,  \nRiccardo Terribili 1,2, Piero Ruscitti 42, Emanuela Del Giudice 43, Samar Tharwat 44,45, Antonio Luca Brucato 46,  \nBenson Ogunjimi 47,48,49,50, Andrea Hinojosa-Azaola 36, Alberto Balistreri 51, Claudia Fabiani 2,52, Bruno Frediani 1,2 and Luca Cantarini 1,2*  \n1 Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behet ’s Disease Clinic, University of Siena, Siena, Italy, 2Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, Italy, 3Gazi University Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Türkiye, 4 Internal Medicine Department, Rheum","cbCaitr1ztkoHPqK","https://ap.wps.com/l/cbCaitr1ztkoHPqK","pdf",1081409,"English","# Overview\n## Study design and data source\n## Cancer risk and associated factors\n## Publication details and citation","[{\"question\":\"What condition is studied regarding cancer development risk?\",\"answer\":\"Familial Mediterranean fever is the primary condition assessed for risk of cancer development.\"},{\"question\":\"What dataset supports the study findings?\",\"answer\":\"The study uses registries from the international AIDA Network.\"},{\"question\":\"How is the cohort study structured?\",\"answer\":\"The research is described as an ambidirectional cohort study.\"}]","Risk for cancer development in familial Mediterranean fever and associated predisposing factors - an ambidirectional cohort study from the international AIDA Network registries | PDF",1789996686]