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Methods: This retrospective study reviewed medical charts of acute CRAO patients from a single tertiary center, analyzing ocular and systemic conditions at first visit and demographic data. Results: Among 87 eligible eyes, 13 developed ocular NV (15%). CKD and dialysis history and systemic comorbidities were more frequent in the NV group. Multivariate analysis found CKD (HR 9.27) and glaucoma history (HR 7.52) as significant risk factors, especially with dialysis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/risk-factors-for-ocular-neovascularization-after-central-retinal-artery-occlusion/436760/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/risk-factors-for-ocular-neovascularization-after-central-retinal-artery-occlusion/436760.png","ImageObject",300,407,{"name":92,"@type":93},"Fahsai","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the incidence of ocular neovascularization after central retinal artery occlusion?","Question",{"text":112,"@type":113},"Among 87 eligible eyes, 13 developed ocular NV, giving an incidence of 15% after CRAO.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which conditions were more common in patients who developed ocular NV after CRAO?",{"text":117,"@type":113},"Hypertension, diabetes mellitus, history of stroke, chronic kidney disease (CKD), and age at first visit were higher in the ocular NV group; most CKD patients in that group had undergone dialysis.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the significant risk factors identified by multivariate regression?",{"text":121,"@type":113},"CKD (hazard ratio [HR] 9.27) and glaucoma history (HR 7.52) were significant risk factors for developing ocular NV after CRAO, particularly among patients undergoing dialysis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436760,1790739935,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},549768702563,"https://ap-avatar.wpscdn.com/avatar/8000c4aa63b76e948b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786536092046926083","J Chin MedAssoc  \nOriginal article  \nRisk factors for ocular neovascularization after central retinal artery occlusion  \nWen-Jung Loa,b, Yu-Ching Lina, Hsin-Yi Changc, Mei-Ju Chena,b,*  \naDepartment of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bDepartment of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cDepartment of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC  \nAbstract  \nBackground: To report the incidence and risk factors associated with ocular neovascularization (NV) in patients with central retinal artery occlusion (CRAO) .  \nMethods: This retrospective study included patients diagnosed with acute CRAO in a single tertiary center. Medical charts were reviewed for ocular NV occurrences. We analyzed systemic and ocular conditions on first visit and demographic data.  \nResults: Eighty-seven eyes were eligible for this study. Among these, 13 eyes had ocular NV after CRAO, with an incidence of 15% . The prevalences of hypertension, diabetes mellitus, history of stroke, chronic kidney disease (CKD), and age at first visit were higher among patients with ocular NV than among patients without ocular NV after CRAO. Moreover, most patients with CKD in the ocular NV group had undergone dialysis. A multivariate regression analysis revealed that CKD (hazard ratio [HR]: 9.27, 95% CI, 1.87-46.05, p = 0 .006) and glaucoma history (HR: 7.52, 95% CI, 1.14-49.46, p = 0 .036) were significant risk factors for developing ocular NV among patients with CRAO.  \nConclusion: CKD and glaucoma history were significant risk factors for developing ocular NV after CRAO, particularly among patients that underwent dialysis.  \nKeywords: Central retinal artery occlusion; Chronic kidney disease; Dialysis; Glaucoma; Ocular neovascularization; Risk factor  \n1. INTRODUCTION  \nOcular neovascularization (NV) occurs in eyes with chronic ischemia.1 Ocular NV is common among patients with proliferative diabetic retinopathy (PDR), central retinal vein occlusion, or ocular ischemic syndrome.2,3 In contrast, in central retinal artery occlusion (CRAO), artery obstruction by emboli may cause irreversible damage to the adjacent tissues, and thus, reduce the demand for oxygenation.4 Therefore, ocular NV may not develop under this acute condition. Nonetheless, 10% to 20% of patients with CRAO develop ocular NV within 3 months.4–10 In light of these observations, the exact mechanism for developing NV after CRAO remains under investigation.  \nThe prevalence of CRAO is around 1/100 000.11 Although rare, it is devastating because there is no effective treatment, and the visual prognosis is very poor. Moreover, CRAO increases the risk of developing ocular NV.12 Therefore, it is important to identify the risk factors associated with ocular NV development  \n*Address correspondence. Dr. Mei-Ju Chen, Department of Ophthalmology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail address: mjchen9069@gmail.com](ROC. E-mail address: mjchen9069@gmail.com) (M.-J. Chen).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 880-885.  \nReceived November 4, 2021; accepted May 21, 2022.  \ndoi: 10. 1097/JCMA.0000000000000766.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nafter CRAO. This knowledge could provide clues for preventing the occurrence of ocular NV.  \nSome vascular-related risk factors were previously identified in patients with CRAO, including hypertension, stroke, and diabetes mellitus (DM) .13 However, little information is available on which patients are mo","cbCaiqsvnDAzHL6D","https://ap.wps.com/l/cbCaiqsvnDAzHL6D","pdf",509739,"English","# Introduction\n# Methods\n## Study population\n# Results\n# Discussion\n# Conclusion","[{\"question\":\"What was the incidence of ocular neovascularization after central retinal artery occlusion?\",\"answer\":\"Among 87 eligible eyes, 13 developed ocular NV, giving an incidence of 15% after CRAO.\"},{\"question\":\"Which conditions were more common in patients who developed ocular NV after CRAO?\",\"answer\":\"Hypertension, diabetes mellitus, history of stroke, chronic kidney disease (CKD), and age at first visit were higher in the ocular NV group; most CKD patients in that group had undergone dialysis.\"},{\"question\":\"What were the significant risk factors identified by multivariate regression?\",\"answer\":\"CKD (hazard ratio [HR] 9.27) and glaucoma history (HR 7.52) were significant risk factors for developing ocular NV after CRAO, particularly among patients undergoing dialysis.\"}]","Risk factors for ocular neovascularization after central retinal artery occlusion | PDF",1790678973,15]