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A retrospective cohort study assessed clinicopathological factors and the association with Helicobacter pylori (H. pylori) in 369 patients with 382 lesions. MSGENs occurred in 27 cases, with higher intestinal metaplasia frequency and initial tumor location in upper/middle stomach. The cumulative incidence was increased in HIM and INUM groups, and spontaneous H. pylori disappearance was more frequent in MSGEN patients.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/risk-factors-for-developing-metachronous-superficial-gastric-epithelial-neoplasms-after-endoscopic-submucosal-dissection/330347/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/risk-factors-for-developing-metachronous-superficial-gastric-epithelial-neoplasms-after-endoscopic-submucosal-dissection/330347.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s primary goal after endoscopic submucosal dissection (ESD)?","Question",{"text":113,"@type":114},"To identify clinicopathological risk factors for the occurrence of metachronous superficial gastric epithelial neoplasms (MSGENs) after ESD and evaluate the association with Helicobacter pylori (H. pylori).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the study designed and who were the participants?",{"text":118,"@type":114},"A retrospective cohort study included 369 patients with 382 lesions treated with ESD for adenoma or early gastric cancer.",{"name":120,"@type":111,"acceptedAnswer":121},"Which factors were associated with a higher risk of MSGENs?",{"text":122,"@type":114},"Histological intestinal metaplasia (HIM) and the initial neoplasm location in the upper or middle stomach (INUM) were more frequent in MSGEN cases, and cumulative incidence was higher in HIM and INUM groups.",{"name":124,"@type":111,"acceptedAnswer":125},"What did the results show about Helicobacter pylori (H. pylori)?",{"text":126,"@type":114},"Spontaneous disappearance of H. pylori occurred more often in the MSGEN group, supporting HIM, INUM, and spontaneous H. pylori disappearance as potential risk factors after ESD.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},330347,1790068680,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":144,"language":145,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":146,"faqs":147,"seo_title":148,"seo_description":67,"update_tm":149,"read_time":150},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Journal of  \nClinical Medicine  \nArticle  \nRisk Factors for Developing Metachronous Superficial Gastric Epithelial Neoplasms after Endoscopic Submucosal Dissection  \nTsunehiro Suzuki 1, Kenichi Goda 1, *, Manabu Ishikawa 1, Shintaro Yamaguchi 1, Tomonori Yoshinaga 1, Masayuki Kondo 1, Mimari Kanazawa 1, Yasuhito Kunogi 1, Takanao Tanaka 1, Akira Kanamori 1, Keiichiro Abe 1, Akira Yamamiya 1, Takeshi Sugaya 1, Keiichi Tominaga 1, Hidetsugu Yamagishi 2, Hironori Masuyama 3 and Atsushi Irisawa 1  \nCitation: Suzuki, T.; Goda, K.;  \nIshikawa, M.; Yamaguchi, S.; Yoshinaga, T.; Kondo, M.; Kanazawa, M.; Kunogi, Y.; Tanaka, T.; Kanamori, A.; et al. Risk Factors for Developing Metachronous Superficial Gastric Epithelial Neoplasms after Endoscopic Submucosal Dissection. J. Clin. Med. 2024, 13, 1587. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/jcm13061587](10.3390/jcm13061587)  \nAcademic Editor: Akira Tsuburaya  \nReceived: 29 January 2024  \nRevised: 6 March 2024  \nAccepted: 8 March 2024  \nPublished: 10 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Gastroenterology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi Mibu, Tochigi 321-0293, Japan; [s-t-hiro@dokkyomed.ac.jp](s-t-hiro@dokkyomed.ac.jp) (T.S.); [d-ishi@dokkyomed.ac.jp](d-ishi@dokkyomed.ac.jp) (M.I.); [y-shin-y@dokkyomed.ac.jp](y-shin-y@dokkyomed.ac.jp) (S.Y.); [tomo-y@dokkyomed.ac.jp](tomo-y@dokkyomed.ac.jp) (T.Y.); [m-kondo@dokkyomed.ac.jp](m-kondo@dokkyomed.ac.jp) (M.K.); [mimari77@dokkyomed.ac.jp](mimari77@dokkyomed.ac.jp) (M.K.); [ykunogi@dokkyomed.ac.jp](ykunogi@dokkyomed.ac.jp) (Y.K.); [tana1986@dokkyomed.ac.jp](tana1986@dokkyomed.ac.jp) (T.T.); [k-akira@dokkyomed.ac.jp](k-akira@dokkyomed.ac.jp) (A.K.); [abe9841@dokkyomed.ac.jp](abe9841@dokkyomed.ac.jp) (K.A.); [akira-y@dokkyomed.ac.jp](akira-y@dokkyomed.ac.jp) (A.Y.); [t-sugaya@dokkyomed.ac.jp](t-sugaya@dokkyomed.ac.jp) (T.S.); [tominaga@dokkyomed.ac.jp](tominaga@dokkyomed.ac.jp) (K.T.); [irisawa@dokkyomed.ac.jp](irisawa@dokkyomed.ac.jp) (A.I.)  \n2 Department of Diagnostic Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi Mibu, Tochigi 321-0293, Japan; [yamagisi@dokkyomed.ac.jp](yamagisi@dokkyomed.ac.jp)  \n3 Masuyama Gastroenterology Clinic, 83-413 Kajiya Otawara, Tochigi 324-0046, Japan; [mgic@titan.ocn.ne.jp](mgic@titan.ocn.ne.jp)  \n* Correspondence: [goda@dokkyomed.ac.jp](goda@dokkyomed.ac.jp); Tel.: +81-282-87-2147; Fax: +81-282-86-7761  \nAbstract: Background: Although endoscopic submucosal dissection (ESD) provides a high rate of curative resection, the remaining gastric mucosa after ESD is at risk for metachronous superficial gastric epithelial neoplasms (MSGENs) . It leaves room for risk factors for developing MSGENs after ESD. This study aimed to identify clinicopathological risk factors for the occurrence of MSGENs, and to evaluate the association of Helicobacter pylori (H. pylori) with the MSGENs. Methods: We conducted a retrospective cohort study including 369 patients with 382 lesions that underwent ESD for adenoma/early gastric cancer. Results: Twenty-seven MSGENs occurred. The subjects were divided into MSGEN and not-MSGEN groups. There was a significantly higher frequency of histological intestinal metaplasia (HIM) and initial neoplasm location in the upper or middle parts (INUM) in the MSGEN group. The HIM and INUM groups had a significantly higher cumulative incidence of MSGENs. We compared 27 patients from the MSGEN group and 27 patients from the not-MSGEN group that were matched to the MSGEN group for variables including HIM and INUM. There was a significantly higher frequency of the spontaneous disappearan","cbCaijx9YHW7hrRo","https://ap.wps.com/l/cbCaijx9YHW7hrRo","pdf",4297576,14,"English","# Abstract\n# Introduction","[{\"question\":\"What was the study’s primary goal after endoscopic submucosal dissection (ESD)?\",\"answer\":\"To identify clinicopathological risk factors for the occurrence of metachronous superficial gastric epithelial neoplasms (MSGENs) after ESD and evaluate the association with Helicobacter pylori (H. pylori).\"},{\"question\":\"How was the study designed and who were the participants?\",\"answer\":\"A retrospective cohort study included 369 patients with 382 lesions treated with ESD for adenoma or early gastric cancer.\"},{\"question\":\"Which factors were associated with a higher risk of MSGENs?\",\"answer\":\"Histological intestinal metaplasia (HIM) and the initial neoplasm location in the upper or middle stomach (INUM) were more frequent in MSGEN cases, and cumulative incidence was higher in HIM and INUM groups.\"},{\"question\":\"What did the results show about Helicobacter pylori (H. pylori)?\",\"answer\":\"Spontaneous disappearance of H. pylori occurred more often in the MSGEN group, supporting HIM, INUM, and spontaneous H. pylori disappearance as potential risk factors after ESD.\"}]","Risk Factors for Developing Metachronous Superficial Gastric Epithelial Neoplasms after Endoscopic Submucosal Dissection | PDF",1789988366,35]