[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384112-105":59,"doc-detail-384112-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","risk-factors-and-prognosis-of-stroke-in-gynecologic-cancer-patients","Risk Factors and Prognosis of Stroke in Gynecologic Cancer Patients","","Increased longevity and cancer prevalence raise the likelihood of stroke among patients with malignancies. This single-center retrospective cohort study assessed risk factors for stroke and its prognostic impact in cervical, endometrial, and epithelial ovarian cancer patients by classifying onset timing relative to cancer diagnosis and treatment. Among 644 patients, 54 (8.4%) experienced stroke. Univariate analyses linked stroke with overall survival, while multivariate results associated stroke with age and hypertension, not survival; age, pulmonary thromboembolism/deep vein thrombosis, histologic grade, and tumor stage were associated with survival.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/risk-factors-and-prognosis-of-stroke-in-gynecologic-cancer-patients/384112/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/risk-factors-and-prognosis-of-stroke-in-gynecologic-cancer-patients/384112.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How many patients experienced stroke, and what was the overall incidence?","Question",{"text":112,"@type":113},"Among 644 patients, 54 (8.4%) experienced stroke, which was higher than the general population rate described in the article.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors were independently associated with stroke in multivariate analysis?",{"text":117,"@type":113},"In multivariate analysis, stroke was significantly associated with age and hypertension, rather than overall survival.",{"name":119,"@type":110,"acceptedAnswer":120},"Did stroke independently affect progression-free or overall survival?",{"text":121,"@type":113},"No. Stroke was not found to be an independent prognostic factor for progression-free or overall survival; other variables such as age and specific comorbidities were associated with survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384112,1790530450,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","cancers   \nArticle  \nRisk Factors and Prognosis of Stroke in Gynecologic Cancer Patients  \nJi Young Kwon 1,2, Kena Park 1,2, Jeong Min Song 1,2, Seung Yeon Pyeon 1, Seon Hwa Lee 3, Young Shin Chung 1 and Jong-Min Lee 1, *  \nCitation: Kwon, J.Y.; Park, K.; Song, J.M.; Pyeon, S.Y.; Lee, S.H.; Chung, Y.S.; Lee, J.-M. Risk Factors and Prognosis of Stroke in Gynecologic Cancer Patients. Cancers 2023, 15, 4895. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15194895  \nAcademic Editor: Linus T. Chuang  \nReceived: 11 September 2023  \nRevised: 3 October 2023  \nAccepted: 8 October 2023  \nPublished: 9 October 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul 05278, Republic of Korea; [kwonji33@gmail.com](kwonji33@gmail.com) (J.Y.K.); [kenapark2013@gmail.com](kenapark2013@gmail.com) (K.P.); [jeongsmile@gmail.com](jeongsmile@gmail.com) (J.M.S.); [pyun0522@gmail.com](pyun0522@gmail.com) (S.Y.P.); [bono03@naver.com](bono03@naver.com) (Y.S.C.)  \n2 Department of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea  \n3 Medical Big Data Research Center, Research Institute of Clinical Medicine, Kyung Hee University Hospital at Gangdong, Seoul 05278, Republic of Korea; [sproutlife@naver.com](sproutlife@naver.com)  \n* Correspondence: [kgo02@hanmail.net](kgo02@hanmail.net)  \nSimple Summary: The impact of stroke on patients with cancer is of significant concern, as gynecologic oncologists occasionally face medical challenges in managing patients who experience stroke during cancer treatment. However, the relationship between stroke and gynecological cancers has not been sufficiently explored. Here, we evaluated the risk factors for stroke in patients with three major types of gynecological cancers and their effects on cancer prognosis. Out of the 644 patients, 54 (8.4%) experienced a stroke, which is notably higher than the 2% of stroke occurrence rate in the general population. Stroke is significantly associated with age and hypertension. Contrary to our initial concerns, stroke was not found to be an independent prognostic factor for progression-free or overall survival. These findings suggest the importance of an appropriate management plan that considers the age, medical history, and tumor characteristics of the patient, rather than an excessive concern about stroke itself.  \nAbstract: Increased life expectancy and cancer prevalence rates expose patients to a higher risk of developing other comorbidities such as stroke. This study aimed to evaluate the risk factors for and prognosis of stroke in patients with gynecological cancers. A single-center retrospective cohort study was conducted on patients with cervical, endometrial, and epithelial ovarian cancers. Patients were classified into three groups based on the period of stroke onset: at least one year before cancer diagnosis, within one year before cancer diagnosis to six months after the last treatment date, and six months after the last treatment date. Among the 644 patients, stroke occurred in 54 (8.4%) . In univariate analysis, stroke was significantly associated with overall survival. In contrast, in multivariate analysis, stroke was significantly associated with age and hypertension, but not with overall survival. Age, pulmonary thromboembolism/deep vein thrombosis, histological grade, and tumor stage were significantly associated with overall survival. Therefore, it is important to establish an appropriate examination and treatment plan for patients with gynecologic cancers using a multidisciplinary approach that incorporates ","cbCaig1HGlb3p7KR","https://ap.wps.com/l/cbCaig1HGlb3p7KR","pdf",1200383,12,"English","# Introduction\n## Stroke in the context of aging and cancer\n# Methods\n## Study design and patient classification\n# Results\n## Stroke occurrence and survival analyses\n## Factors associated with survival\n# Discussion\n## Clinical implications for multidisciplinary management","[{\"question\":\"How many patients experienced stroke, and what was the overall incidence?\",\"answer\":\"Among 644 patients, 54 (8.4%) experienced stroke, which was higher than the general population rate described in the article.\"},{\"question\":\"Which factors were independently associated with stroke in multivariate analysis?\",\"answer\":\"In multivariate analysis, stroke was significantly associated with age and hypertension, rather than overall survival.\"},{\"question\":\"Did stroke independently affect progression-free or overall survival?\",\"answer\":\"No. Stroke was not found to be an independent prognostic factor for progression-free or overall survival; other variables such as age and specific comorbidities were associated with survival.\"}]","Risk Factors and Prognosis of Stroke in Gynecologic Cancer Patients | PDF",1790261268]