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The review synthesizes evidence on germline mutations, inheritance patterns, tumor presentations, and fertility preservation approaches. Findings highlight predominantly autosomal dominant pathogenic variants that elevate susceptibility to gynecologic tumors with different risk levels. Genomic sequencing enables identification of high-risk individuals, supporting prevention, early detection, and precision management together with counseling and fertility preservation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/risk-assessment-and-fertility-counseling-for-hereditary-gynecological-cancer-syndromes/370873/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/risk-assessment-and-fertility-counseling-for-hereditary-gynecological-cancer-syndromes/370873.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What hereditary cancer syndromes are most commonly linked to gynecologic cancers in this review?","Question",{"text":112,"@type":113},"The review highlights HBOC, Lynch syndrome, Cowden syndrome, Peutz–Jeghers syndrome, and hereditary leiomyomatosis and renal cell carcinoma (HLRCC), all associated with gynecologic cancers. HBOC and Lynch syndrome are described as the most common in clinical settings.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is fertility preservation emphasized for patients with hereditary gynecologic cancers?",{"text":117,"@type":113},"Fertility preservation is considered crucial because gynecologic oncogenesis can have obvious deleterious effects on female fertility. The review also notes the shift in modern oncology goals toward optimizing quality of life.",{"name":119,"@type":110,"acceptedAnswer":120},"How do genomic sequencing and genetic counseling contribute to management of high-risk individuals?",{"text":121,"@type":113},"Genomic sequencing helps identify high-risk individuals by detecting germline pathogenic mutations. Standardized genetic counseling then supports risk assessment, fertility preservation planning, and formulation of individualized management strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},370873,1790493492,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Cancer Medicine  \n|  REVIEW  OPEN ACCESS \u003Cbr>Risk Assessment and Fertility Counseling for Hereditary Gynecological Cancer Syndromes\u003Cbr>Mei Zhao | Xiao-ming Teng | Qiang Yan | Fan Hao \u003Cbr>Reproductive Medical Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China Correspondence: Qiang Yan ([1905241@tongji.edu.cn](1905241@tongji.edu.cn)) | Fan Hao ([2105048@tongji.edu.cn](2105048@tongji.edu.cn))\u003Cbr>Received: 19 April 2025 | Revised: 26 July 2025 | Accepted: 25 August 2025\u003Cbr>Keywords: autosomal dominant inheritance | cervical cancer | endometrial cancer | fertility preservation | genetic counseling | hereditary gynecological cancers | ovarian cancer |  |\n| --- | --- |\n| ABSTRACT\u003Cbr>Objective: To review the genetic basis, clinical characteristics, and management strategies of hereditary gynecologic cancers associated with hereditary cancer syndromes.\u003Cbr>Methods: Literature on germline mutations, inheritance patterns, clinical manifestations, and fertility preservation strategies was reviewed.\u003Cbr>Results: Germline pathogenic mutations, predominantly inherited in an autosomal dominant manner, increase susceptibility to gynecologic tumors with varying risks. Genomic sequencing has facilitated identification of high-risk individuals, underscoring the importance of tailored prevention, early detection, and treatment. Standardized counseling supports risk assessment, fertility preservation, and the formulation of individualized management strategies.\u003Cbr>Conclusion: Comprehensive genetic counseling and precision-based approaches are essential for effective prevention, diagnosis, and treatment of hereditary gynecologic cancers, while also addressing fertility preservation in affected patients. |  |\n| 1 | Introduction | carcinoma syndrome (HLRCC) [3] . With advancement in testing technology, more people can be expected to be diagnosed |\n| Hereditary cancer syndromes (HCS) are characterized by | with HCS [4] and that the population of people who develop |\n| pathogenic mutations in one or more genes that cause tumors | hereditary gynecologic cancers (HGC) will gradually increase |\n| to develop in one or more organs of an individual, and the mu- | Fertility preservation (FP) is particularly important consider- |\n| tated gene(s) can be inherited from generation to generation in | ing the obvious deleterious effects of gynecologic oncogenesis |\n| the family line, most often in an autosomal dominant manner, | on female fertility and the shift in the goal of modern oncol- |\n| and account for about 5% to 10% of all tumors [1]. Hereditary tu- | ogy from maintaining the life of the patient to optimizing her |\n| mors make up a small percentage of the population. However, their susceptibility can have a significant impact on family | quality of life. |\n| members. More than 50 different HCS have been identified, | Obstetrician–Gynecologists and reproductive medicine physi- |\n| and this number will continue to increase over the coming [2] . | cians need to be knowledgeable about hereditary gynecologic |\n| The most common HCS related to gynecologic tumors include | neoplasms and strategies for their prevention, and provide coun- |\n| hereditary breast and ovarian cancer (OC) syndrome (HBOC), | seling related to gynecologic oncology for high-risk patients, |\n| Lynch syndrome (LS), Cowden syndrome (CS), Peutz–Jeghers | including FP and preimplantation genetic testing (PGT), and |\n| syndrome (PJS), and hereditary leiomyomatosis and renal cell | develop a treatment plan. |\n| Mei Zhao and Xiao-ming Teng contributed equally to this work and share first authorship. |  |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2025 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. |  |\n\nCancer Medicine, 2025; 14:e71206 1 of 10  \n[https://","cbCaioMxC6Pf2KWZ","https://ap.wps.com/l/cbCaioMxC6Pf2KWZ","pdf",365600,"English","# Abstract\n# Introduction\n## Hereditary Gynecological Cancers Syndrome\n## BRCA-Related Breast/Ovarian Cancer Syndrome (Hereditary Breast and Ovarian Cancer: HBOC)\n## Lynch Syndrome","[{\"question\":\"What hereditary cancer syndromes are most commonly linked to gynecologic cancers in this review?\",\"answer\":\"The review highlights HBOC, Lynch syndrome, Cowden syndrome, Peutz–Jeghers syndrome, and hereditary leiomyomatosis and renal cell carcinoma (HLRCC), all associated with gynecologic cancers. HBOC and Lynch syndrome are described as the most common in clinical settings.\"},{\"question\":\"Why is fertility preservation emphasized for patients with hereditary gynecologic cancers?\",\"answer\":\"Fertility preservation is considered crucial because gynecologic oncogenesis can have obvious deleterious effects on female fertility. The review also notes the shift in modern oncology goals toward optimizing quality of life.\"},{\"question\":\"How do genomic sequencing and genetic counseling contribute to management of high-risk individuals?\",\"answer\":\"Genomic sequencing helps identify high-risk individuals by detecting germline pathogenic mutations. Standardized genetic counseling then supports risk assessment, fertility preservation planning, and formulation of individualized management strategies.\"}]","Risk Assessment and Fertility Counseling for Hereditary Gynecological Cancer Syndromes | PDF",1790190736,25]