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Presentations mapped a path using breast cancer biology, early detection, treatment, and endocrine therapy, emphasizing prevention strategies shaped by hormonal environment in different life phases or benign conditions. The program advanced risk prediction, risk-reducing agents, and biomarker-driven trials, highlighting health equity and ending with a Shark Tank competition for innovative approaches.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rise-up-for-breast-cancer-2024-conference-highlights-takeaways/455513/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rise-up-for-breast-cancer-2024-conference-highlights-takeaways/455513.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is RISE UP for breast cancer 2024 focused on?","Question",{"text":112,"@type":113},"It focuses on rethinking breast cancer prevention and risk reduction by applying hormonal management across a woman’s life course, supported by breast cancer biology, screening, treatment, and endocrine therapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What kinds of biomarker-based trials were discussed?",{"text":117,"@type":113},"The meeting discussed trials involving lower or intermittent doses of standard prevention agents, repurposed drugs already approved for other health purposes, and lifestyle-intervention strategies alone or combined.",{"name":119,"@type":110,"acceptedAnswer":120},"How did RISE UP address health equity?",{"text":121,"@type":113},"It emphasized health equity through comprehensive reproductive health access, equitable representation in clinical trials, and strategies to educate women, providers, and advocates about disparities in care and risk reduction.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455513,1791198018,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Breast Cancer Research and Treatment (2026) 215:53 [https://doi.org/10.1007/s10549-025-07848-7](https://doi.org/10.1007/s10549-025-07848-7)  \nRISE UP for breast cancer 2024: conference highlights & takeaways  \nTaylor Glatt1 · Katherine Leggat‑Barr1 · Nandini Seth2 · Diane Heditsian2 · Laura van ’t Veer2 · Lajos Pusztai3 · Elissa Price2 · Nola Hylton2 · Silvia Formenti4 · Hope Rugo5 · Laura Fejerman6 · AdetunjiT. Toriola7 · Carol Fabian8 · Andrea De Censi9 · Daniel Grossman2 · Olufunmilayo Olopade10 · Andrea Jackson2 · Sara Horton11 · Kim Rhoads2 · Carol Lange12 · Virginia Borges13 · Elizabeth Garner14 · Judy Garber15 · Douglas Yee12 · Laura Esserman2  \nReceived: 20 August 2025 / Accepted: 13 October 2025 / Published online: 6 January 2026 © The Author(s) 2026  \nAbstract  \nRISE UP (Revolutionizing Investigations to StEp Up Prevention) for breast cancer brought together leading cancer specialists, women’s health providers, basic and population scientists, regulators, politicians, industry leaders, patient advocates, and more from around the world to discuss and chart a radical rethinking of breast cancer prevention and risk reduction through a lens of hormonal management across a woman’s life course. The presentations at RISE UP were organized to outline a path forward by leveraging what we know about breast cancer biology, early detection, treatment, and endocrine therapy toward a better and sustainable approach for breast cancer prevention. Important conference considerations were to expand our thinking about prevention by broadly considering how the hormonal environment during different life phases or common benign conditions could be better managed to minimize breast cancer risk. This set the stage for transitioning to advances in risk prediction, promising risk-reducing agents, and biomarker-driven trials to test them. Biomarker-based trials discussed focused on 1) lower or intermittent doses of standard prevention agents, 2) drugs already approved for other health purposes, and 3) maximizing benefits from lifestyle interventions alone or in combination. Throughout RISE UP, there was a strong focus on promoting health equity, including comprehensive reproductive health access, equitable representation in clinical trials, and strategies to educate women, providers, and advocates about disparities in care and how to successfully reduce them. The meeting concluded with a competition for innovative approaches to breast cancer prevention that could be integrated into hormonal and women’s health interventions. RISE UP was an innovative conference that provided a forum for cross-cutting topics in women’s health that do not currently exist. The insights shared at RISE UP will be paradigm shifting in breast cancer prevention and women’s health space in the years to come.  \n* Laura Esserman [laura.esserman@ucsf.edu](laura.esserman@ucsf.edu)  \n1 Tufts University School of Medicine, Tufts University, Boston, MA, USA  \n2 University of California, 1825 4Th St, 3Rd Floor, San Francisco, CA 94158, USA  \n3 Yale University Cancer Center, Yale University, New Haven, CT, USA  \n4 Weill Cornell Medical College, New York, NY, USA  \n5 City of Hope Cancer Center, Duarte, CA, USA  \n6 UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, CA, USA  \n7 Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA  \n8 Medical Center, University of Kansas, Kansas City, KS, USA  \n9 Division of Medical Oncology, Department of Medicine, E.O. Ospedali Galliera, Genoa, Italy  \n10 Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, IL, USA  \n11 Access and Diversity, Quantum Leap Healthcare Collaborative, San Francisco, CA, USA  \n12 Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA  \n13 Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA  \n14 American Medical Women’s Association, L","cbCait5UHi3wh01M","https://ap.wps.com/l/cbCait5UHi3wh01M","pdf",534297,"English","# Abstract\n# Introduction\n## Conference goals and scope\n## Key sessions and research themes\n## Outcomes and competitions","[{\"question\":\"What is RISE UP for breast cancer 2024 focused on?\",\"answer\":\"It focuses on rethinking breast cancer prevention and risk reduction by applying hormonal management across a woman’s life course, supported by breast cancer biology, screening, treatment, and endocrine therapy.\"},{\"question\":\"What kinds of biomarker-based trials were discussed?\",\"answer\":\"The meeting discussed trials involving lower or intermittent doses of standard prevention agents, repurposed drugs already approved for other health purposes, and lifestyle-intervention strategies alone or combined.\"},{\"question\":\"How did RISE UP address health equity?\",\"answer\":\"It emphasized health equity through comprehensive reproductive health access, equitable representation in clinical trials, and strategies to educate women, providers, and advocates about disparities in care and risk reduction.\"}]","RISE UP for breast cancer 2024 - conference highlights - takeaways | PDF",1790743294]